Xiaoyan Zhao

Kaiwen Geng, Zhiyi Shi, Xiaoyan Zhao et al.

Abstract Background: Pulmonary function tests (PFTs) and computed tomography (CT) imaging are vital in diagnosing, managing, and monitoring lung diseases. A common issue in practice is the lack of access to recorded pulmonary functions despite available chest CT scans. Purpose: To develop and validate a deep learning algorithm for predicting pulmonary function directly from chest CT scans. Methods: The development cohort came from the Pittsburgh Lung Screening Study (PLuSS) (n=3619). The validation cohort came from the Specialized Centers of Clinically Oriented Research (SCCOR) in COPD (n=662). A deep learning model called BeyondCT, combining a three-dimensional (3D) convolutional neural network (CNN) and Vision Transformer (ViT) architecture, was used to predict forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) from non-contrasted inspiratory chest CT scans. A 3D CNN model without ViT was used for comparison. Subject demographics (age, gender, smoking status) were also incorporated into the model. Performance was compared to actual PFTs using mean absolute error (MAE, L), percentage error, and R square. Results: The 3D-CNN model achieved MAEs of 0.395 L and 0.383 L, percentage errors of 13.84% and 18.85%, and R square of 0.665 and 0.679 for FVC and FEV1, respectively. The BeyondCT model without demographics had MAEs of 0.362 L and 0.371 L, percentage errors of 10.89% and 14.96%, and R square of 0.719 and 0.727, respectively. Including demographics improved performance (p<0.05), with MAEs of 0.356 L and 0.353 L, percentage errors of 10.79% and 14.82%, and R square of 0.77 and 0.739 for FVC and FEV1 in the test set. Conclusion: The BeyondCT model showed robust performance in predicting lung function from non-contrast inspiratory chest CT scans.

Xiaoteng Shen, Rui Zhang, Xiaoyan Zhao et al.

The emergence of large language models (LLMs) has revolutionized the capabilities of text comprehension and generation. Multi-modal generation attracts great attention from both the industry and academia, but there is little work on personalized generation, which has important applications such as recommender systems. This paper proposes the first method for personalized multimodal generation using LLMs, showcases its applications and validates its performance via an extensive experimental study on two datasets. The proposed method, Personalized Multimodal Generation (PMG for short) first converts user behaviors (e.g., clicks in recommender systems or conversations with a virtual assistant) into natural language to facilitate LLM understanding and extract user preference descriptions. Such user preferences are then fed into a generator, such as a multimodal LLM or diffusion model, to produce personalized content. To capture user preferences comprehensively and accurately, we propose to let the LLM output a combination of explicit keywords and implicit embeddings to represent user preferences. Then the combination of keywords and embeddings are used as prompts to condition the generator. We optimize a weighted sum of the accuracy and preference scores so that the generated content has a good balance between them. Compared to a baseline method without personalization, PMG has a significant improvement on personalization for up to 8% in terms of LPIPS while retaining the accuracy of generation.