Chien-Chin Hsu

Jun-En Ding, Chien-Chin Hsu, Feng Liu

Parkinson's Disease (PD) affects millions globally, impacting movement. Prior research utilized deep learning for PD prediction, primarily focusing on medical images, neglecting the data's underlying manifold structure. This work proposes a multimodal approach encompassing both image and non-image features, leveraging contrastive cross-view graph fusion for PD classification. We introduce a novel multimodal co-attention module, integrating embeddings from separate graph views derived from low-dimensional representations of images and clinical features. This enables more robust and structured feature extraction for improved multi-view data analysis. Additionally, a simplified contrastive loss-based fusion method is devised to enhance cross-view fusion learning. Our graph-view multimodal approach achieves an accuracy of 0.91 and an area under the receiver operating characteristic curve (AUC) of 0.93 in five-fold cross-validation. It also demonstrates superior predictive capabilities on non-image data compared to solely machine learning-based methods.

Guan-Hua Huang, Wan-Chen Lai, Tai-Been Chen et al.

Parkinson's disease (PD), a degenerative disorder of the central nervous system, is commonly diagnosed using functional medical imaging techniques such as single-photon emission computed tomography (SPECT). In this study, we utilized two SPECT data sets (n = 634 and n = 202) from different hospitals to develop a model capable of accurately predicting PD stages, a multiclass classification task. We used the entire three-dimensional (3D) brain images as input and experimented with various model architectures. Initially, we treated the 3D images as sequences of two-dimensional (2D) slices and fed them sequentially into 2D convolutional neural network (CNN) models pretrained on ImageNet, averaging the outputs to obtain the final predicted stage. We also applied 3D CNN models pretrained on Kinetics-400. Additionally, we incorporated an attention mechanism to account for the varying importance of different slices in the prediction process. To further enhance model efficacy and robustness, we simultaneously trained the two data sets using weight sharing, a technique known as cotraining. Our results demonstrated that 2D models pretrained on ImageNet outperformed 3D models pretrained on Kinetics-400, and models utilizing the attention mechanism outperformed both 2D and 3D models. The cotraining technique proved effective in improving model performance when the cotraining data sets were sufficiently large.

Jun-En Ding, Chien-Chin Hsu, Chi-Hsiang Chu et al.

The classification of medical images is a pivotal aspect of disease diagnosis, often enhanced by deep learning techniques. However, traditional approaches typically focus on unimodal medical image data, neglecting the integration of diverse non-image patient data. This paper proposes a novel Cross-Graph Modal Contrastive Learning (CGMCL) framework for multimodal structured data from different data domains to improve medical image classification. The model effectively integrates both image and non-image data by constructing cross-modality graphs and leveraging contrastive learning to align multimodal features in a shared latent space. An inter-modality feature scaling module further optimizes the representation learning process by reducing the gap between heterogeneous modalities. The proposed approach is evaluated on two datasets: a Parkinson's disease (PD) dataset and a public melanoma dataset. Results demonstrate that CGMCL outperforms conventional unimodal methods in accuracy, interpretability, and early disease prediction. Additionally, the method shows superior performance in multi-class melanoma classification. The CGMCL framework provides valuable insights into medical image classification while offering improved disease interpretability and predictive capabilities.