Haoran Luo

Yu Feng, Zhen Tian, Yifan Zhu et al.

The key challenge of cross-modal domain-incremental learning (DIL) is to enable the learning model to continuously learn from novel data with different feature distributions under the same task without forgetting old ones. However, existing top-performing methods still cause high forgetting rates, by lacking intra-domain knowledge extraction and inter-domain common prompting strategy. In this paper, we propose a simple yet effective framework, CP-Prompt, by training limited parameters to instruct a pre-trained model to learn new domains and avoid forgetting existing feature distributions. CP-Prompt captures intra-domain knowledge by compositionally inserting personalized prompts on multi-head self-attention layers and then learns the inter-domain knowledge with a common prompting strategy. CP-Prompt shows superiority compared with state-of-the-art baselines among three widely evaluated DIL tasks. The source code is available at https://github.com/dannis97500/CP_Prompt.

Wenjin Liu, Haoran Luo, Xueyuan Lin et al.

Recently, advanced large language models (LLMs) have emerged at an increasingly rapid pace. However, when faced with complex problems, most users are often unable to provide accurate and effective prompts to interact with LLMs, thus limiting the performance of LLMs. To address this challenge, we propose Prompt-R1, an end-to-end reinforcement learning framework that uses a small-scale LLM to collaborate with large-scale LLMs, replacing user interaction to solve problems better. This collaboration is cast as a multi-turn prompt interaction, where the small-scale LLM thinks and generates prompts, and the large-scale LLM performs complex reasoning. A dual-constrained reward is designed to optimize for correctness, generation quality, and reasoning accuracy. Prompt-R1 provides a plug-and-play framework that supports both inference and training with various large-scale LLMs. Experiments on multiple public datasets show that Prompt-R1 significantly outperforms baseline models across tasks. Our code is publicly available at https://github.com/QwenQKing/Prompt-R1.

Yu Feng, Yangli-ao Geng, Yifan Zhu et al.

Federated learning (FL) has gained widespread attention for its privacy-preserving and collaborative learning capabilities. Due to significant statistical heterogeneity, traditional FL struggles to generalize a shared model across diverse data domains. Personalized federated learning addresses this issue by dividing the model into a globally shared part and a locally private part, with the local model correcting representation biases introduced by the global model. Nevertheless, locally converged parameters more accurately capture domain-specific knowledge, and current methods overlook the potential benefits of these parameters. To address these limitations, we propose PM-MoE architecture. This architecture integrates a mixture of personalized modules and an energy-based personalized modules denoising, enabling each client to select beneficial personalized parameters from other clients. We applied the PM-MoE architecture to nine recent model-split-based personalized federated learning algorithms, achieving performance improvements with minimal additional training. Extensive experiments on six widely adopted datasets and two heterogeneity settings validate the effectiveness of our approach. The source code is available at \url{https://github.com/dannis97500/PM-MOE}.

Shan Cong, Zhiling Sang, Hongwei Liu et al.

The distinct characteristics of multiomics data, including complex interactions within and across biological layers and disease heterogeneity (e.g., heterogeneity in etiology and clinical symptoms), drive us to develop novel designs to address unique challenges in multiomics prediction. In this paper, we propose the multi-view knowledge transfer learning (MVKTrans) framework, which transfers intra- and inter-omics knowledge in an adaptive manner by reviewing data heterogeneity and suppressing bias transfer, thereby enhancing classification performance. Specifically, we design a graph contrastive module that is trained on unlabeled data to effectively learn and transfer the underlying intra-omics patterns to the supervised task. This unsupervised pretraining promotes learning general and unbiased representations for each modality, regardless of the downstream tasks. In light of the varying discriminative capacities of modalities across different diseases and/or samples, we introduce an adaptive and bi-directional cross-omics distillation module. This module automatically identifies richer modalities and facilitates dynamic knowledge transfer from more informative to less informative omics, thereby enabling a more robust and generalized integration. Extensive experiments on four real biomedical datasets demonstrate the superior performance and robustness of MVKTrans compared to the state-of-the-art. Code and data are available at https://github.com/Yaolab-fantastic/MVKTrans.

Zhengpeng Shi, Haoran Luo

Domain-Specific Chinese Relation Extraction (DSCRE) aims to extract relations between entities from domain-specific Chinese text. Despite the rapid development of PLMs in recent years, especially LLMs, DSCRE still faces three core challenges: complex network structure design, poor awareness, and high consumption of fine-tuning. Given the impressive performance of large language models (LLMs) in natural language processing, we propose a new framework called CRE-LLM. This framework is based on fine-tuning open-source LLMs, such as Llama-2, ChatGLM2, and Baichuan2. CRE-LLM enhances the logic-awareness and generative capabilities of the model by constructing an appropriate prompt and utilizing open-source LLMs for instruction-supervised fine-tuning. And then it directly extracts the relations of the given entities in the input textual data, which improving the CRE approach. To demonstrate the effectiveness of the proposed framework, we conducted extensive experiments on two domain-specific CRE datasets, FinRE and SanWen. The experimental results show that CRE-LLM is significantly superior and robust, achieving state-of-the-art (SOTA) performance on the FinRE dataset. This paper introduces a novel approach to domain-specific relation extraction (DSCRE) tasks that are semantically more complex by combining LLMs with triples. Our code is publicly available.

Shan Cong, Zhoujie Fan, Hongwei Liu et al.

Brain transcriptomics provides insights into the molecular mechanisms by which the brain coordinates its functions and processes. However, existing multimodal methods for predicting Alzheimer's disease (AD) primarily rely on imaging and sometimes genetic data, often neglecting the transcriptomic basis of brain. Furthermore, while striving to integrate complementary information between modalities, most studies overlook the informativeness disparities between modalities. Here, we propose TMM, a trusted multiview multimodal graph attention framework for AD diagnosis, using extensive brain-wide transcriptomics and imaging data. First, we construct view-specific brain regional co-function networks (RRIs) from transcriptomics and multimodal radiomics data to incorporate interaction information from both biomolecular and imaging perspectives. Next, we apply graph attention (GAT) processing to each RRI network to produce graph embeddings and employ cross-modal attention to fuse transcriptomics-derived embedding with each imagingderived embedding. Finally, a novel true-false-harmonized class probability (TFCP) strategy is designed to assess and adaptively adjust the prediction confidence of each modality for AD diagnosis. We evaluate TMM using the AHBA database with brain-wide transcriptomics data and the ADNI database with three imaging modalities (AV45-PET, FDG-PET, and VBM-MRI). The results demonstrate the superiority of our method in identifying AD, EMCI, and LMCI compared to state-of-the-arts. Code and data are available at https://github.com/Yaolab-fantastic/TMM.