Amritpal Singh

h-index16
2papers
1,454citations

2 Papers

6.6LGNov 7, 2023
Class-Incremental Continual Learning for General Purpose Healthcare Models

Amritpal Singh, Mustafa Burak Gurbuz, Shiva Souhith Gantha et al.

Healthcare clinics regularly encounter dynamic data that changes due to variations in patient populations, treatment policies, medical devices, and emerging disease patterns. Deep learning models can suffer from catastrophic forgetting when fine-tuned in such scenarios, causing poor performance on previously learned tasks. Continual learning allows learning on new tasks without performance drop on previous tasks. In this work, we investigate the performance of continual learning models on four different medical imaging scenarios involving ten classification datasets from diverse modalities, clinical specialties, and hospitals. We implement various continual learning approaches and evaluate their performance in these scenarios. Our results demonstrate that a single model can sequentially learn new tasks from different specialties and achieve comparable performance to naive methods. These findings indicate the feasibility of recycling or sharing models across the same or different medical specialties, offering another step towards the development of general-purpose medical imaging AI that can be shared across institutions.

2.6LGJul 15, 2024
GraphPrint: Extracting Features from 3D Protein Structure for Drug Target Affinity Prediction

Amritpal Singh

Accurate drug target affinity prediction can improve drug candidate selection, accelerate the drug discovery process, and reduce drug production costs. Previous work focused on traditional fingerprints or used features extracted based on the amino acid sequence in the protein, ignoring its 3D structure which affects its binding affinity. In this work, we propose GraphPrint: a framework for incorporating 3D protein structure features for drug target affinity prediction. We generate graph representations for protein 3D structures using amino acid residue location coordinates and combine them with drug graph representation and traditional features to jointly learn drug target affinity. Our model achieves a mean square error of 0.1378 and a concordance index of 0.8929 on the KIBA dataset and improves over using traditional protein features alone. Our ablation study shows that the 3D protein structure-based features provide information complementary to traditional features.