Kyungmi Lee

Karma Phuntsho, Abdullah, Kyungmi Lee et al.

Foundation models (FMs) have emerged as a transformative paradigm in medical image analysis, offering the potential to provide generalizable, task-agnostic solutions across a wide range of clinical tasks and imaging modalities. Their capacity to learn transferable representations from large-scale data has the potential to address the limitations of conventional task-specific models. However, adaptation of FMs to real-world clinical practice remains constrained by key challenges, including domain shifts, limited availability of high-quality annotated data, substantial computational demands, and strict privacy requirements. This review presents a comprehensive assessment of strategies for adapting FMs to the specific demands of medical imaging. We examine approaches such as supervised fine-tuning, domain-specific pretraining, parameter-efficient fine-tuning, self-supervised learning, hybrid methods, and multimodal or cross-modal frameworks. For each, we evaluate reported performance gains, clinical applicability, and limitations, while identifying trade-offs and unresolved challenges that prior reviews have often overlooked. Beyond these established techniques, we also highlight emerging directions aimed at addressing current gaps. These include continual learning to enable dynamic deployment, federated and privacy-preserving approaches to safeguard sensitive data, hybrid self-supervised learning to enhance data efficiency, data-centric pipelines that combine synthetic generation with human-in-the-loop validation, and systematic benchmarking to assess robust generalization under real-world clinical variability. By outlining these strategies and associated research gaps, this review provides a roadmap for developing adaptive, trustworthy, and clinically integrated FMs capable of meeting the demands of real-world medical imaging.

Kyungmi Lee, Anantha P. Chandrakasan

We identify three common cases that lead to overestimation of adversarial accuracy against bounded first-order attack methods, which is popularly used as a proxy for adversarial robustness in empirical studies. For each case, we propose compensation methods that either address sources of inaccurate gradient computation, such as numerical instability near zero and non-differentiability, or reduce the total number of back-propagations for iterative attacks by approximating second-order information. These compensation methods can be combined with existing attack methods for a more precise empirical evaluation metric. We illustrate the impact of these three cases with examples of practical interest, such as benchmarking model capacity and regularization techniques for robustness. Overall, our work shows that overestimated adversarial accuracy that is not indicative of robustness is prevalent even for conventionally trained deep neural networks, and highlights cautions of using empirical evaluation without guaranteed bounds.

Euntae Choi, Kyungmi Lee, Kiyoung Choi

Incremental class learning, a scenario in continual learning context where classes and their training data are sequentially and disjointedly observed, challenges a problem widely known as catastrophic forgetting. In this work, we propose a novel incremental class learning method that can significantly reduce memory overhead compared to previous approaches. Apart from conventional classification scheme using softmax, our model bases on an autoencoder to extract prototypes for given inputs so that no change in its output unit is required. It stores only the mean of prototypes per class to perform metric-based classification, unlike rehearsal approaches which rely on large memory or generative model. To mitigate catastrophic forgetting, regularization methods are applied on our model when a new task is encountered. We evaluate our method by experimenting on CIFAR-100 and CUB-200-2011 and show that its performance is comparable to the state-of-the-art method with much lower additional memory cost.