Yang Tao

Chiao-Yi Wang, Faranguisse Kakhi Sadrieh, Yi-Ting Shen et al.

The measurement of retinal blood flow (RBF) in capillaries can provide a powerful biomarker for the early diagnosis and treatment of ocular diseases. However, no single modality can determine capillary flowrates with high precision. Combining erythrocyte-mediated angiography (EMA) with optical coherence tomography angiography (OCTA) has the potential to achieve this goal, as EMA can measure the absolute 2D RBF of retinal microvasculature and OCTA can provide the 3D structural images of capillaries. However, multimodal retinal image registration between these two modalities remains largely unexplored. To fill this gap, we establish MEMO, the first public multimodal EMA and OCTA retinal image dataset. A unique challenge in multimodal retinal image registration between these modalities is the relatively large difference in vessel density (VD). To address this challenge, we propose a segmentation-based deep-learning framework (VDD-Reg) and a new evaluation metric (MSD), which provide robust results despite differences in vessel density. VDD-Reg consists of a vessel segmentation module and a registration module. To train the vessel segmentation module, we further designed a two-stage semi-supervised learning framework (LVD-Seg) combining supervised and unsupervised losses. We demonstrate that VDD-Reg outperforms baseline methods quantitatively and qualitatively for cases of both small VD differences (using the CF-FA dataset) and large VD differences (using our MEMO dataset). Moreover, VDD-Reg requires as few as three annotated vessel segmentation masks to maintain its accuracy, demonstrating its feasibility.

Chiao-Yi Wang, Havish S Gadde, Yi-Ting Shen et al.

Capillary-level retinal blood flow (RBF) has strong potential as a biomarker for various ocular diseases. However, modalities for measuring capillary-level RBF remain limited. Erythrocyte-mediated angiography (EMA), an emerging imaging technique, enables capillary-level RBF measurement by visualizing individual erythrocytes, yet automated erythrocyte detection and tracking, which are essential for quantifying blood flow, remain largely unexplored. To address this gap, we propose EMTrack, a novel framework featuring a flow-context module for erythrocyte detection that distinguishes moving from paused cells and a topology-aware tracking strategy that enables tracking under large inter-frame displacements and substantial motion variations. In addition, we establish RBF-EMA, a new EMA dataset with comprehensive erythrocyte detection and tracking annotations. Experimental results demonstrate that our method outperforms baseline methods both quantitatively and qualitatively on detection and tracking tasks in the RBF-EMA dataset. Moreover, RBF quantification results highlight the strong potential of our framework for automated retinal blood flow measurement.

Tao Yang, Ruibin Li, Yangming Shi et al.

Diffusion models have shown impressive performance in many visual generation and manipulation tasks. Many existing methods focus on training a model for a specific task, especially, text-to-video (T2V) generation, while many other works focus on finetuning the pretrained T2V model for image-to-video (I2V), video-to-video (V2V), image and video manipulation tasks, etc. However, training a strong T2V foundation model requires a large amount of high-quality annotations, which is very costly. In addition, many existing models can perform only one or several tasks. In this work, we introduce a unified framework, namely many-for-many, which leverages the available training data from many different visual generation and manipulation tasks to train a single model for those different tasks. Specifically, we design a lightweight adapter to unify the different conditions in different tasks, then employ a joint image-video learning strategy to progressively train the model from scratch. Our joint learning leads to a unified visual generation and manipulation model with improved video generation performance. In addition, we introduce depth maps as a condition to help our model better perceive the 3D space in visual generation. Two versions of our model are trained with different model sizes (8B and 2B), each of which can perform more than 10 different tasks. In particular, our 8B model demonstrates highly competitive performance in video generation tasks compared to open-source and even commercial engines. Our models and source codes are available at https://github.com/leeruibin/MfM.git.

Behzad Sadrfaridpour, Yiannis Aloimonos, Miao Yu et al.

Oysters are an essential species in the Chesapeake Bay living ecosystem. Oysters are filter feeders and considered the vacuum cleaners of the Chesapeake Bay that can considerably improve the Bay's water quality. Many oyster restoration programs have been initiated in the past decades and continued to date. Advancements in robotics and artificial intelligence have opened new opportunities for aquaculture. Drone-like ROVs with high maneuverability are getting more affordable and, if equipped with proper sensory devices, can monitor the oysters. This work presents our efforts for videography of the Chesapeake bay bottom using an ROV, constructing a database of oysters, implementing Mask R-CNN for detecting oysters, and counting their number in a video by tracking them.