Yan Zhou

Mianxin Liu, Jingyang Zhang, Yao Wang et al.

Brain disorders in the early and late life of humans potentially share pathological alterations in brain functions. However, the key evidence from neuroimaging data for pathological commonness remains unrevealed. To explore this hypothesis, we build a deep learning model, using multi-site functional magnetic resonance imaging data (N=4,410, 6 sites), for classifying 5 different brain disorders from healthy controls, with a set of common features. Our model achieves 62.6(1.9)% overall classification accuracy on data from the 6 investigated sites and detects a set of commonly affected functional subnetworks at different spatial scales, including default mode, executive control, visual, and limbic networks. In the deep-layer feature representation for individual data, we observe young and aging patients with disorders are continuously distributed, which is in line with the clinical concept of the "spectrum of disorders". The revealed spectrum underlying early- and late-life brain disorders promotes the understanding of disorder comorbidities in the lifespan.

Yaxin Liu, Yan Zhou, Ziming Li et al.

As an important multimodal sentiment analysis task, Joint Multimodal Aspect-Sentiment Analysis (JMASA), aiming to jointly extract aspect terms and their associated sentiment polarities from the given text-image pairs, has gained increasing concerns. Existing works encounter two limitations: (1) multi-level modality noise, i.e., instance- and feature-level noise; and (2) multi-grained semantic gap, i.e., coarse- and fine-grained gap. Both issues may interfere with accurate identification of aspect-sentiment pairs. To address these limitations, we propose a novel framework named RNG for JMASA. Specifically, to simultaneously reduce multi-level modality noise and multi-grained semantic gap, we design three constraints: (1) Global Relevance Constraint (GR-Con) based on text-image similarity for instance-level noise reduction, (2) Information Bottleneck Constraint (IB-Con) based on the Information Bottleneck (IB) principle for feature-level noise reduction, and (3) Semantic Consistency Constraint (SC-Con) based on mutual information maximization in a contrastive learning way for multi-grained semantic gap reduction. Extensive experiments on two datasets validate our new state-of-the-art performance.

Zhicheng Zhang, Wuyou Xia, Chenxi Zhao et al.

Multimodal large language models (MLLMs) recently showed strong capacity in integrating data among multiple modalities, empowered by a generalizable attention architecture. Advanced methods predominantly focus on language-centric tuning while less exploring multimodal tokens mixed through attention, posing challenges in high-level tasks that require fine-grained cognition and emotion understanding. In this work, we identify the attention deficit disorder problem in multimodal learning, caused by inconsistent cross-modal attention and layer-by-layer decayed attention activation. To address this, we propose a novel attention mechanism, termed MOdular Duplex Attention (MODA), simultaneously conducting the inner-modal refinement and inter-modal interaction. MODA employs a correct-after-align strategy to effectively decouple modality alignment from cross-layer token mixing. In the alignment phase, tokens are mapped to duplex modality spaces based on the basis vectors, enabling the interaction between visual and language modality. Further, the correctness of attention scores is ensured through adaptive masked attention, which enhances the model's flexibility by allowing customizable masking patterns for different modalities. Extensive experiments on 21 benchmark datasets verify the effectiveness of MODA in perception, cognition, and emotion tasks. Source code and demo are available in https://zzcheng.top/MODA.