Matteo Pennisi

Matteo Pennisi, Federica Proietto Salanitri, Giovanni Bellitto et al.

In the medical field, multi-center collaborations are often sought to yield more generalizable findings by leveraging the heterogeneity of patient and clinical data. However, recent privacy regulations hinder the possibility to share data, and consequently, to come up with machine learning-based solutions that support diagnosis and prognosis. Federated learning (FL) aims at sidestepping this limitation by bringing AI-based solutions to data owners and only sharing local AI models, or parts thereof, that need then to be aggregated. However, most of the existing federated learning solutions are still at their infancy and show several shortcomings, from the lack of a reliable and effective aggregation scheme able to retain the knowledge learned locally to weak privacy preservation as real data may be reconstructed from model updates. Furthermore, the majority of these approaches, especially those dealing with medical data, relies on a centralized distributed learning strategy that poses robustness, scalability and trust issues. In this paper we present a federated and decentralized learning strategy, FedER, that, exploiting experience replay and generative adversarial concepts, effectively integrates features from local nodes, providing models able to generalize across multiple datasets while maintaining privacy. FedER is tested on two tasks -- tuberculosis and melanoma classification -- using multiple datasets in order to simulate realistic non-i.i.d. medical data scenarios. Results show that our approach achieves performance comparable to standard (non-federated) learning and significantly outperforms state-of-the-art federated methods in their centralized (thus, more favourable) formulation. Code is available at https://github.com/perceivelab/FedER

Matteo Boschini, Lorenzo Bonicelli, Angelo Porrello et al.

This work investigates the entanglement between Continual Learning (CL) and Transfer Learning (TL). In particular, we shed light on the widespread application of network pretraining, highlighting that it is itself subject to catastrophic forgetting. Unfortunately, this issue leads to the under-exploitation of knowledge transfer during later tasks. On this ground, we propose Transfer without Forgetting (TwF), a hybrid approach building upon a fixed pretrained sibling network, which continuously propagates the knowledge inherent in the source domain through a layer-wise loss term. Our experiments indicate that TwF steadily outperforms other CL methods across a variety of settings, averaging a 4.81% gain in Class-Incremental accuracy over a variety of datasets and different buffer sizes.

Giovanni Bellitto, Matteo Pennisi, Simone Palazzo et al.

In Continual Learning (CL), a neural network is trained on a stream of data whose distribution changes over time. In this context, the main problem is how to learn new information without forgetting old knowledge (i.e., Catastrophic Forgetting). Most existing CL approaches focus on finding solutions to preserve acquired knowledge, so working on the past of the model. However, we argue that as the model has to continually learn new tasks, it is also important to put focus on the present knowledge that could improve following tasks learning. In this paper we propose a new, simple, CL algorithm that focuses on solving the current task in a way that might facilitate the learning of the next ones. More specifically, our approach combines the main data stream with a secondary, diverse and uncorrelated stream, from which the network can draw auxiliary knowledge. This helps the model from different perspectives, since auxiliary data may contain useful features for the current and the next tasks and incoming task classes can be mapped onto auxiliary classes. Furthermore, the addition of data to the current task is implicitly making the classifier more robust as we are forcing the extraction of more discriminative features. Our method can outperform existing state-of-the-art models on the most common CL Image Classification benchmarks.

Matteo Pennisi, Federica Proietto Salanitri, Giovanni Bellitto et al.

Generative Adversarial Networks (GANs) have demonstrated their ability to generate synthetic samples that match a target distribution. However, from a privacy perspective, using GANs as a proxy for data sharing is not a safe solution, as they tend to embed near-duplicates of real samples in the latent space. Recent works, inspired by k-anonymity principles, address this issue through sample aggregation in the latent space, with the drawback of reducing the dataset by a factor of k. Our work aims to mitigate this problem by proposing a latent space navigation strategy able to generate diverse synthetic samples that may support effective training of deep models, while addressing privacy concerns in a principled way. Our approach leverages an auxiliary identity classifier as a guide to non-linearly walk between points in the latent space, minimizing the risk of collision with near-duplicates of real samples. We empirically demonstrate that, given any random pair of points in the latent space, our walking strategy is safer than linear interpolation. We then test our path-finding strategy combined to k-same methods and demonstrate, on two benchmarks for tuberculosis and diabetic retinopathy classification, that training a model using samples generated by our approach mitigate drops in performance, while keeping privacy preservation.

Simone Carnemolla, Chiara Russo, Simone Palazzo et al.

Ensuring trustworthiness in open-world visual recognition requires models that are interpretable, fair, and robust to distribution shifts. Yet modern vision systems are increasingly deployed as proprietary black-box APIs, exposing only output probabilities and hiding architecture, parameters, gradients, and training data. This opacity prevents meaningful auditing, bias detection, and failure analysis. Existing explanation methods assume white- or gray-box access or knowledge of the training distribution, making them unusable in these real-world settings. We introduce UNBOX, a framework for class-wise model dissection under fully data-free, gradient-free, and backpropagation-free constraints. UNBOX leverages Large Language Models and text-to-image diffusion models to recast activation maximization as a purely semantic search driven by output probabilities. The method produces human-interpretable text descriptors that maximally activate each class, revealing the concepts a model has implicitly learned, the training distribution it reflects, and potential sources of bias. We evaluate UNBOX on ImageNet-1K, Waterbirds, and CelebA through semantic fidelity tests, visual-feature correlation analyses and slice-discovery auditing. Despite operating under the strictest black-box constraints, UNBOX performs competitively with state-of-the-art white-box interpretability methods. This demonstrates that meaningful insight into a model's internal reasoning can be recovered without any internal access, enabling more trustworthy and accountable visual recognition systems.

Salvatore Calcagno, Matteo Pennisi, Federica Proietto Salanitri et al.

Continual learning requires balancing plasticity and stability while mitigating catastrophic forgetting. Inspired by human dreaming as a mechanism for internal simulation and knowledge restructuring, we introduce Dream2Learn (D2L), a framework in which a model autonomously generates structured synthetic experiences from its own internal representations and uses them for self-improvement. Rather than reconstructing past data as in generative replay, D2L enables a classifier to create novel, semantically distinct dreamed classes that are coherent with its learned knowledge yet do not correspond to previously observed data. These dreamed samples are produced by conditioning a frozen diffusion model through soft prompt optimization driven by the classifier itself. The generated data are not used to replace memory, but to expand and reorganize the representation space, effectively allowing the network to self-train on internally synthesized concepts. By integrating dreamed classes into continual training, D2L proactively structures latent features to support forward knowledge transfer and adaptation to future tasks. This prospective self-training mechanism mirrors the role of sleep in consolidating and reorganizing memory, turning internal simulations into a tool for improved generalization. Experiments on Mini-ImageNet, FG-ImageNet, and ImageNet-R demonstrate that D2L consistently outperforms strong rehearsal-based baselines and achieves positive forward transfer, confirming its ability to enhance adaptability through internally generated training signals.

Chiara Maria Russo, Simone Carnemolla, Simone Palazzo et al.

Interpreting the decisions of deep image classifiers remains challenging, particularly in black-box settings where model internals are inaccessible. We introduce OCCAM, a framework for open-set causal concept explanation and ontology induction in vision models. OCCAM discovers visual concepts in an open-set manner, localizes them via text-guided segmentation, and performs object-level interventions by removing concepts to measure changes in class confidence, estimating each concept's causal contribution. Beyond local explanations, OCCAM aggregates interventional evidence across a dataset to induce a structured concept ontology that captures how classifiers globally organize visual concepts. Reasoning over this ontology reveals consistent dependencies between concepts, exposes latent causal relations, and uncovers systematic model biases. Experiments on Broden and ImageNet-S across multiple classifiers show that OCCAM improves explanation quality in open-set black-box settings while providing richer global insight than per-image attribution methods.

Simone Carnemolla, Salvatore Calcagno, Daniela Giordano et al.

Contrastively trained vision-language models such as CLIP provide strong zero-shot transfer by aligning images and text in a shared embedding space. However, adapting these models to downstream tasks without degrading their open-vocabulary generalization remains challenging. Existing parameter-efficient adaptation methods typically improve task specialization through learned prompts, adapters, or multimodal transformations, where adaptation capacity is primarily expressed through additional trainable parameters. Inspired by recent latent reasoning methods in language models, we investigate a complementary perspective: can adaptation emerge from iterative reasoning on latent representations rather than from increasing parameter count alone? We introduce PERL (Parameter-Efficient Reasoning in CLIP Latent Space), a lightweight adaptation framework that augments a frozen CLIP model with a compact shared reasoning module applied recurrently across refinement steps. At each step, PERL generates a latent reasoning token conditioned on the current representation and injects it into an intermediate encoder layer, progressively refining higher-level semantic representations while preserving CLIP's pretrained multimodal structure. Across 15 benchmarks spanning base-to-novel generalization, cross-dataset transfer, and out-of-distribution ImageNet variants, PERL achieves the best parameter-performance trade-off among the compared methods under a fast-adaptation few-shot setting, combining strong novel-class accuracy and competitive transfer performance with only about 6K trainable parameters, up to 817x fewer than the largest compared approach. Overall, our results suggest that iterative latent reasoning provides a complementary adaptation mechanism to parameter scaling in discriminative vision-language models.

Giovanni Bellitto, Federica Proietto Salanitri, Matteo Pennisi et al.

We present SAM, a biologically-plausible selective attention-driven modulation approach to enhance classification models in a continual learning setting. Inspired by neurophysiological evidence that the primary visual cortex does not contribute to object manifold untangling for categorization and that primordial attention biases are still embedded in the modern brain, we propose to employ auxiliary saliency prediction features as a modulation signal to drive and stabilize the learning of a sequence of non-i.i.d. classification tasks. Experimental results confirm that SAM effectively enhances the performance (in some cases up to about twenty percent points) of state-of-the-art continual learning methods, both in class-incremental and task-incremental settings. Moreover, we show that attention-based modulation successfully encourages the learning of features that are more robust to the presence of spurious features and to adversarial attacks than baseline methods. Code is available at: https://github.com/perceivelab/SAM.

Simone Carnemolla, Matteo Pennisi, Sarinda Samarasinghe et al.

Understanding and explaining the behavior of machine learning models is essential for building transparent and trustworthy AI systems. We introduce DEXTER, a data-free framework that employs diffusion models and large language models to generate global, textual explanations of visual classifiers. DEXTER operates by optimizing text prompts to synthesize class-conditional images that strongly activate a target classifier. These synthetic samples are then used to elicit detailed natural language reports that describe class-specific decision patterns and biases. Unlike prior work, DEXTER enables natural language explanation about a classifier's decision process without access to training data or ground-truth labels. We demonstrate DEXTER's flexibility across three tasks-activation maximization, slice discovery and debiasing, and bias explanation-each illustrating its ability to uncover the internal mechanisms of visual classifiers. Quantitative and qualitative evaluations, including a user study, show that DEXTER produces accurate, interpretable outputs. Experiments on ImageNet, Waterbirds, CelebA, and FairFaces confirm that DEXTER outperforms existing approaches in global model explanation and class-level bias reporting. Code is available at https://github.com/perceivelab/dexter.

Amelia Sorrenti, Giovanni Bellitto, Federica Proietto Salanitri et al.

We propose Wake-Sleep Consolidated Learning (WSCL), a learning strategy leveraging Complementary Learning System theory and the wake-sleep phases of the human brain to improve the performance of deep neural networks for visual classification tasks in continual learning settings. Our method learns continually via the synchronization between distinct wake and sleep phases. During the wake phase, the model is exposed to sensory input and adapts its representations, ensuring stability through a dynamic parameter freezing mechanism and storing episodic memories in a short-term temporary memory (similarly to what happens in the hippocampus). During the sleep phase, the training process is split into NREM and REM stages. In the NREM stage, the model's synaptic weights are consolidated using replayed samples from the short-term and long-term memory and the synaptic plasticity mechanism is activated, strengthening important connections and weakening unimportant ones. In the REM stage, the model is exposed to previously-unseen realistic visual sensory experience, and the dreaming process is activated, which enables the model to explore the potential feature space, thus preparing synapses to future knowledge. We evaluate the effectiveness of our approach on three benchmark datasets: CIFAR-10, Tiny-ImageNet and FG-ImageNet. In all cases, our method outperforms the baselines and prior work, yielding a significant performance gain on continual visual classification tasks. Furthermore, we demonstrate the usefulness of all processing stages and the importance of dreaming to enable positive forward transfer.

Matteo Pennisi, Giovanni Bellitto, Simone Palazzo et al.

We present DiffExplainer, a novel framework that, leveraging language-vision models, enables multimodal global explainability. DiffExplainer employs diffusion models conditioned on optimized text prompts, synthesizing images that maximize class outputs and hidden features of a classifier, thus providing a visual tool for explaining decisions. Moreover, the analysis of generated visual descriptions allows for automatic identification of biases and spurious features, as opposed to traditional methods that often rely on manual intervention. The cross-modal transferability of language-vision models also enables the possibility to describe decisions in a more human-interpretable way, i.e., through text. We conduct comprehensive experiments, which include an extensive user study, demonstrating the effectiveness of DiffExplainer on 1) the generation of high-quality images explaining model decisions, surpassing existing activation maximization methods, and 2) the automated identification of biases and spurious features.

Simone Carnemolla, Matteo Pennisi, Chiara Russo et al.

We introduce SeeingSounds, a lightweight and modular framework for audio-to-image generation that leverages the interplay between audio, language, and vision-without requiring any paired audio-visual data or training on visual generative models. Rather than treating audio as a substitute for text or relying solely on audio-to-text mappings, our method performs dual alignment: audio is projected into a semantic language space via a frozen language encoder, and, contextually grounded into the visual domain using a vision-language model. This approach, inspired by cognitive neuroscience, reflects the natural cross-modal associations observed in human perception. The model operates on frozen diffusion backbones and trains only lightweight adapters, enabling efficient and scalable learning. Moreover, it supports fine-grained and interpretable control through procedural text prompt generation, where audio transformations (e.g., volume or pitch shifts) translate into descriptive prompts (e.g., "a distant thunder") that guide visual outputs. Extensive experiments across standard benchmarks confirm that SeeingSounds outperforms existing methods in both zero-shot and supervised settings, establishing a new state of the art in controllable audio-to-visual generation.

Alessio Masano, Matteo Pennisi, Federica Proietto Salanitri et al.

CLIP has revolutionized zero-shot learning by enabling task generalization without fine-tuning. While prompting techniques like CoOp and CoCoOp enhance CLIP's adaptability, their effectiveness in Federated Learning (FL) remains an open challenge. Existing federated prompt learning approaches, such as FedCoOp and FedTPG, improve performance but face generalization issues, high communication costs, and reliance on a central server, limiting scalability and privacy. We propose Zero-shot Decentralized Federated Learning (ZeroDFL), a fully decentralized framework that enables zero-shot adaptation across distributed clients without a central coordinator. ZeroDFL employs an iterative prompt-sharing mechanism, allowing clients to optimize and exchange textual prompts to enhance generalization while drastically reducing communication overhead. We validate ZeroDFL on nine diverse image classification datasets, demonstrating that it consistently outperforms--or remains on par with--state-of-the-art federated prompt learning methods. More importantly, ZeroDFL achieves this performance in a fully decentralized setting while reducing communication overhead by 118x compared to FedTPG. These results highlight that our approach not only enhances generalization in federated zero-shot learning but also improves scalability, efficiency, and privacy preservation--paving the way for decentralized adaptation of large vision-language models in real-world applications.

Rutger Hendrix, Giovanni Patanè, Leonardo G. Russo et al.

Foundation models have transformed multimedia analysis by enabling robust and transferable representations across diverse modalities and tasks. However, their static deployment conflicts with growing societal and regulatory demands -- particularly the need to unlearn specific data upon request, as mandated by privacy frameworks such as the GDPR. Traditional unlearning approaches, including retraining, activation editing, or distillation, are often computationally expensive, fragile, and ill-suited for real-time or continuously evolving systems. In this paper, we propose a paradigm shift: rethinking unlearning not as a retroactive intervention but as a built-in capability. We introduce a prompt-based learning framework that unifies knowledge acquisition and removal within a single training phase. Rather than encoding information in model weights, our approach binds class-level semantics to dedicated prompt tokens. This design enables instant unlearning simply by removing the corresponding prompt -- without retraining, model modification, or access to original data. Experiments demonstrate that our framework preserves predictive performance on retained classes while effectively erasing forgotten ones. Beyond utility, our method exhibits strong privacy and security guarantees: it is resistant to membership inference attacks, and prompt removal prevents any residual knowledge extraction, even under adversarial conditions. This ensures compliance with data protection principles and safeguards against unauthorized access to forgotten information, making the framework suitable for deployment in sensitive and regulated environments. Overall, by embedding removability into the architecture itself, this work establishes a new foundation for designing modular, scalable and ethically responsive AI models.

Luca Palazzo, Matteo Pennisi, Federica Proietto Salanitri et al.

In this paper, we present FedRewind, a novel approach to decentralized federated learning that leverages model exchange among nodes to address the issue of data distribution shift. Drawing inspiration from continual learning (CL) principles and cognitive neuroscience theories for memory retention, FedRewind implements a decentralized routing mechanism where nodes send/receive models to/from other nodes in the federation to address spatial distribution challenges inherent in distributed learning (FL). During local training, federation nodes periodically send their models back (i.e., rewind) to the nodes they received them from for a limited number of iterations. This strategy reduces the distribution shift between nodes' data, leading to enhanced learning and generalization performance. We evaluate our method on multiple benchmarks, demonstrating its superiority over standard decentralized federated learning methods and those enforcing specific routing schemes within the federation. Furthermore, the combination of federated and continual learning concepts enables our method to tackle the more challenging federated continual learning task, with data shifts over both space and time, surpassing existing baselines.

Lorenzo Bonicelli, Matteo Boschini, Emanuele Frascaroli et al.

Humans can learn incrementally, whereas neural networks forget previously acquired information catastrophically. Continual Learning (CL) approaches seek to bridge this gap by facilitating the transfer of knowledge to both previous tasks (backward transfer) and future ones (forward transfer) during training. Recent research has shown that self-supervision can produce versatile models that can generalize well to diverse downstream tasks. However, contrastive self-supervised learning (CSSL), a popular self-supervision technique, has limited effectiveness in online CL (OCL). OCL only permits one iteration of the input dataset, and CSSL's low sample efficiency hinders its use on the input data-stream. In this work, we propose Continual Learning via Equivariant Regularization (CLER), an OCL approach that leverages equivariant tasks for self-supervision, avoiding CSSL's limitations. Our method represents the first attempt at combining equivariant knowledge with CL and can be easily integrated with existing OCL methods. Extensive ablations shed light on how equivariant pretext tasks affect the network's information flow and its impact on CL dynamics.

Iacopo Colonnelli, Barbara Cantalupo, Concetto Spampinato et al.

HPC is an enabling platform for AI. The introduction of AI workloads in the HPC applications basket has non-trivial consequences both on the way of designing AI applications and on the way of providing HPC computing. This is the leitmotif of the convergence between HPC and AI. The formalized definition of AI pipelines is one of the milestones of HPC-AI convergence. If well conducted, it allows, on the one hand, to obtain portable and scalable applications. On the other hand, it is crucial for the reproducibility of scientific pipelines. In this work, we advocate the StreamFlow Workflow Management System as a crucial ingredient to define a parametric pipeline, called "CLAIRE COVID-19 Universal Pipeline," which is able to explore the optimization space of methods to classify COVID-19 lung lesions from CT scans, compare them for accuracy, and therefore set a performance baseline. The universal pipeline automatizes the training of many different Deep Neural Networks (DNNs) and many different hyperparameters. It, therefore, requires a massive computing power, which is found in traditional HPC infrastructure thanks to the portability-by-design of pipelines designed with StreamFlow. Using the universal pipeline, we identified a DNN reaching over 90% accuracy in detecting COVID-19 lesions in CT scans.

Matteo Pennisi, Isaak Kavasidis, Concetto Spampinato et al.

COVID-19 infection caused by SARS-CoV-2 pathogen is a catastrophic pandemic outbreak all over the world with exponential increasing of confirmed cases and, unfortunately, deaths. In this work we propose an AI-powered pipeline, based on the deep-learning paradigm, for automated COVID-19 detection and lesion categorization from CT scans. We first propose a new segmentation module aimed at identifying automatically lung parenchyma and lobes. Next, we combined such segmentation network with classification networks for COVID-19 identification and lesion categorization. We compare the obtained classification results with those obtained by three expert radiologists on a dataset consisting of 162 CT scans. Results showed a sensitivity of 90\% and a specificity of 93.5% for COVID-19 detection, outperforming those yielded by the expert radiologists, and an average lesion categorization accuracy of over 84%. Results also show that a significant role is played by prior lung and lobe segmentation that allowed us to enhance performance by over 20 percent points. The interpretation of the trained AI models, moreover, reveals that the most significant areas for supporting the decision on COVID-19 identification are consistent with the lesions clinically associated to the virus, i.e., crazy paving, consolidation and ground glass. This means that the artificial models are able to discriminate a positive patient from a negative one (both controls and patients with interstitial pneumonia tested negative to COVID) by evaluating the presence of those lesions into CT scans. Finally, the AI models are integrated into a user-friendly GUI to support AI explainability for radiologists, which is publicly available at http://perceivelab.com/covid-ai.