Jing Yu

Pedro Mateus, Swier Garst, Jing Yu et al.

Biological age scores are an emerging tool to characterize aging by estimating chronological age based on physiological biomarkers. Various scores have shown associations with aging-related outcomes. This study assessed the relation between an age score based on brain MRI images (BrainAge) and an age score based on metabolomic biomarkers (MetaboAge). We trained a federated deep learning model to estimate BrainAge in three cohorts. The federated BrainAge model yielded significantly lower error for age prediction across the cohorts than locally trained models. Harmonizing the age interval between cohorts further improved BrainAge accuracy. Subsequently, we compared BrainAge with MetaboAge using federated association and survival analyses. The results showed a small association between BrainAge and MetaboAge as well as a higher predictive value for the time to mortality of both scores combined than for the individual scores. Hence, our study suggests that both aging scores capture different aspects of the aging process.

Tianxiu Xie, Keke Gai, Jing Yu et al.

Distributed machine learning enables parallel training of extensive datasets by delegating computing tasks across multiple workers. Despite the cost reduction benefits of distributed machine learning, the dissemination of final model weights often leads to potential conflicts over model ownership as workers struggle to substantiate their involvement in the training computation. To address the above ownership issues and prevent accidental failures and malicious attacks, verifying the computational integrity and effectiveness of workers becomes particularly crucial in distributed machine learning. In this paper, we proposed a novel binary linear tree commitment-based ownership protection model to ensure computational integrity with limited overhead and concise proof. Due to the frequent updates of parameters during training, our commitment scheme introduces a maintainable tree structure to reduce the costs of updating proofs. Distinguished from SNARK-based verifiable computation, our model achieves efficient proof aggregation by leveraging inner product arguments. Furthermore, proofs of model weights are watermarked by worker identity keys to prevent commitments from being forged or duplicated. The performance analysis and comparison with SNARK-based hash commitments validate the efficacy of our model in preserving computational integrity within distributed machine learning.