Ying Xiao

Yuanzheng Ma, Xinyue Wang, Benqi Zhao et al.

Deep learning-based super-resolution models have the potential to revolutionize biomedical imaging and diagnoses by effectively tackling various challenges associated with early detection, personalized medicine, and clinical automation. However, the requirement of an extensive collection of high-resolution images presents limitations for widespread adoption in clinical practice. In our experiment, we proposed an approach to effectively train the deep learning-based super-resolution models using only one real image by leveraging self-generated high-resolution images. We employed a mixed metric of image screening to automatically select images with a distribution similar to ground truth, creating an incrementally curated training data set that encourages the model to generate improved images over time. After five training iterations, the proposed deep learning-based super-resolution model experienced a 7.5\% and 5.49\% improvement in structural similarity and peak-signal-to-noise ratio, respectively. Significantly, the model consistently produces visually enhanced results for training, improving its performance while preserving the characteristics of original biomedical images. These findings indicate a potential way to train a deep neural network in a self-revolution manner independent of real-world human data.

Lianghui Zhu, Xitong Ling, Minxi Ouyang et al.

Gastrointestinal (GI) diseases represent a clinically significant burden, necessitating precise diagnostic approaches to optimize patient outcomes. Conventional histopathological diagnosis suffers from limited reproducibility and diagnostic variability. To overcome these limitations, we develop Digepath, a specialized foundation model for GI pathology. Our framework introduces a dual-phase iterative optimization strategy combining pretraining with fine-screening, specifically designed to address the detection of sparsely distributed lesion areas in whole-slide images. Digepath is pretrained on over 353 million multi-scale images from 210,043 H&E-stained slides of GI diseases. It attains state-of-the-art performance on 33 out of 34 tasks related to GI pathology, including pathological diagnosis, protein expression status prediction, gene mutation prediction, and prognosis evaluation. We further translate the intelligent screening module for early GI cancer and achieve near-perfect 99.70% sensitivity across nine independent medical institutions. This work not only advances AI-driven precision pathology for GI diseases but also bridge critical gaps in histopathological practice.

Siyang Qin, Alessandro Bissacco, Michalis Raptis et al.

We propose an end-to-end trainable network that can simultaneously detect and recognize text of arbitrary shape, making substantial progress on the open problem of reading scene text of irregular shape. We formulate arbitrary shape text detection as an instance segmentation problem; an attention model is then used to decode the textual content of each irregularly shaped text region without rectification. To extract useful irregularly shaped text instance features from image scale features, we propose a simple yet effective RoI masking step. Additionally, we show that predictions from an existing multi-step OCR engine can be leveraged as partially labeled training data, which leads to significant improvements in both the detection and recognition accuracy of our model. Our method surpasses the state-of-the-art for end-to-end recognition tasks on the ICDAR15 (straight) benchmark by 4.6%, and on the Total-Text (curved) benchmark by more than 16%.

RJ Skerry-Ryan, Eric Battenberg, Ying Xiao et al.

We present an extension to the Tacotron speech synthesis architecture that learns a latent embedding space of prosody, derived from a reference acoustic representation containing the desired prosody. We show that conditioning Tacotron on this learned embedding space results in synthesized audio that matches the prosody of the reference signal with fine time detail even when the reference and synthesis speakers are different. Additionally, we show that a reference prosody embedding can be used to synthesize text that is different from that of the reference utterance. We define several quantitative and subjective metrics for evaluating prosody transfer, and report results with accompanying audio samples from single-speaker and 44-speaker Tacotron models on a prosody transfer task.

Yuxuan Wang, Daisy Stanton, Yu Zhang et al.

In this work, we propose "global style tokens" (GSTs), a bank of embeddings that are jointly trained within Tacotron, a state-of-the-art end-to-end speech synthesis system. The embeddings are trained with no explicit labels, yet learn to model a large range of acoustic expressiveness. GSTs lead to a rich set of significant results. The soft interpretable "labels" they generate can be used to control synthesis in novel ways, such as varying speed and speaking style - independently of the text content. They can also be used for style transfer, replicating the speaking style of a single audio clip across an entire long-form text corpus. When trained on noisy, unlabeled found data, GSTs learn to factorize noise and speaker identity, providing a path towards highly scalable but robust speech synthesis.

Shankar Krishnan, Ying Xiao, Rif A. Saurous

Progress in deep learning is slowed by the days or weeks it takes to train large models. The natural solution of using more hardware is limited by diminishing returns, and leads to inefficient use of additional resources. In this paper, we present a large batch, stochastic optimization algorithm that is both faster than widely used algorithms for fixed amounts of computation, and also scales up substantially better as more computational resources become available. Our algorithm implicitly computes the inverse Hessian of each mini-batch to produce descent directions; we do so without either an explicit approximation to the Hessian or Hessian-vector products. We demonstrate the effectiveness of our algorithm by successfully training large ImageNet models (Inception-V3, Resnet-50, Resnet-101 and Inception-Resnet-V2) with mini-batch sizes of up to 32000 with no loss in validation error relative to current baselines, and no increase in the total number of steps. At smaller mini-batch sizes, our optimizer improves the validation error in these models by 0.8-0.9%. Alternatively, we can trade off this accuracy to reduce the number of training steps needed by roughly 10-30%. Our work is practical and easily usable by others -- only one hyperparameter (learning rate) needs tuning, and furthermore, the algorithm is as computationally cheap as the commonly used Adam optimizer.

Yuxuan Wang, RJ Skerry-Ryan, Ying Xiao et al.

Prosodic modeling is a core problem in speech synthesis. The key challenge is producing desirable prosody from textual input containing only phonetic information. In this preliminary study, we introduce the concept of "style tokens" in Tacotron, a recently proposed end-to-end neural speech synthesis model. Using style tokens, we aim to extract independent prosodic styles from training data. We show that without annotation data or an explicit supervision signal, our approach can automatically learn a variety of prosodic variations in a purely data-driven way. Importantly, each style token corresponds to a fixed style factor regardless of the given text sequence. As a result, we can control the prosodic style of synthetic speech in a somewhat predictable and globally consistent way.

Yuxuan Wang, RJ Skerry-Ryan, Daisy Stanton et al.

A text-to-speech synthesis system typically consists of multiple stages, such as a text analysis frontend, an acoustic model and an audio synthesis module. Building these components often requires extensive domain expertise and may contain brittle design choices. In this paper, we present Tacotron, an end-to-end generative text-to-speech model that synthesizes speech directly from characters. Given <text, audio> pairs, the model can be trained completely from scratch with random initialization. We present several key techniques to make the sequence-to-sequence framework perform well for this challenging task. Tacotron achieves a 3.82 subjective 5-scale mean opinion score on US English, outperforming a production parametric system in terms of naturalness. In addition, since Tacotron generates speech at the frame level, it's substantially faster than sample-level autoregressive methods.