Yizhi Zhang

Yizhi Zhang, Lei Fan, Zhulin Tao et al.

Universal, transferable whole-slide image (WSI) representations are central to computational pathology. Incorporating multiple markers (e.g., immunohistochemistry, IHC) alongside H&E enriches H&E-based features with diverse, biologically meaningful information. However, progress is limited by the scarcity of well-aligned multi-stain datasets. Inter-stain misalignment shifts corresponding tissue across slides, hindering consistent patch-level features and degrading slide-level embeddings. To address this, we curated a slide-level aligned, five-stain dataset (H&E, HER2, KI67, ER, PGR) to enable paired H&E-IHC learning and robust cross-stain representation. Leveraging this dataset, we propose Cross-Stain Contrastive Learning (CSCL), a two-stage pretraining framework with a lightweight adapter trained using patch-wise contrastive alignment to improve the compatibility of H&E features with corresponding IHC-derived contextual cues, and slide-level representation learning with Multiple Instance Learning (MIL), which uses a cross-stain attention fusion module to integrate stain-specific patch features and a cross-stain global alignment module to enforce consistency among slide-level embeddings across different stains. Experiments on cancer subtype classification, IHC biomarker status classification, and survival prediction show consistent gains, yielding high-quality, transferable H&E slide-level representations. The code and data are available at https://github.com/lily-zyz/CSCL.

Xuyang Chen, Conglang Zhang, Chuanheng Fu et al.

Driven by the emergence of Controllable Video Diffusion, existing Sim2Real methods for autonomous driving video generation typically rely on explicit intermediate representations to bridge the domain gap. However, these modalities face a fundamental Consistency-Realism Dilemma. Low-level signals (e.g., edges, blurred images) ensure precise control but compromise realism by "baking in" synthetic artifacts, whereas high-level priors (e.g., depth, semantics, HDMaps) facilitate photorealism but lack the structural detail required for consistent guidance. In this work, we present Driving with DINO (DwD), a novel framework that leverages Vision Foundation Module (VFM) features as a unified bridge between the simulation and real-world domains. We first identify that these features encode a spectrum of information, from high-level semantics to fine-grained structure. To effectively utilize this, we employ Principal Subspace Projection to discard the high-frequency elements responsible for "texture baking," while concurrently introducing Random Channel Tail Drop to mitigate the structural loss inherent in rigid dimensionality reduction, thereby reconciling realism with control consistency. Furthermore, to fully leverage DINOv3's high-resolution capabilities for enhancing control precision, we introduce a learnable Spatial Alignment Module that adapts these high-resolution features to the diffusion backbone. Finally, we propose a Causal Temporal Aggregator employing causal convolutions to explicitly preserve historical motion context when integrating frame-wise DINO features, which effectively mitigates motion blur and guarantees temporal stability. Project page: https://albertchen98.github.io/DwD-project/