Chao Li

Anran Liu, Xiaofei Wang, Jing Cai et al.

Hematoxylin and eosin (H&E) staining visualizes histology but lacks specificity for diagnostic markers. Immunohistochemistry (IHC) staining provides protein-targeted staining but is restricted by tissue availability and antibody specificity. Virtual staining, i.e., computationally translating the H&E image to its IHC counterpart while preserving the tissue structure, is promising for efficient IHC generation. Existing virtual staining methods still face key challenges: 1) effective decomposition of staining style and tissue structure, 2) controllable staining process adaptable to diverse tissue and proteins, and 3) rigorous structural consistency modelling to handle the non-pixel-aligned nature of paired H&E and IHC images. This study proposes a mutual-information (MI)-guided score-based diffusion model for unpaired virtual staining. Specifically, we design 1) a global MI-guided energy function that disentangles the tissue structure and staining characteristics across modalities, 2) a novel timestep-customized reverse diffusion process for precise control of the staining intensity and structural reconstruction, and 3) a local MI-driven contrastive learning strategy to ensure the cellular level structural consistency between H&E-IHC images. Extensive experiments demonstrate the our superiority over state-of-the-art approaches, highlighting its biomedical potential. Codes will be open-sourced upon acceptance.

Peizhuo Lv, Yiran Xiahou, Congyi Li et al.

LoRA (Low-Rank Adaptation) has achieved remarkable success in the parameter-efficient fine-tuning of large models. The trained LoRA matrix can be integrated with the base model through addition or negation operation to improve performance on downstream tasks. However, the unauthorized use of LoRAs to generate harmful content highlights the need for effective mechanisms to trace their usage. A natural solution is to embed watermarks into LoRAs to detect unauthorized misuse. However, existing methods struggle when multiple LoRAs are combined or negation operation is applied, as these can significantly degrade watermark performance. In this paper, we introduce LoRAGuard, a novel black-box watermarking technique for detecting unauthorized misuse of LoRAs. To support both addition and negation operations, we propose the Yin-Yang watermark technique, where the Yin watermark is verified during negation operation and the Yang watermark during addition operation. Additionally, we propose a shadow-model-based watermark training approach that significantly improves effectiveness in scenarios involving multiple integrated LoRAs. Extensive experiments on both language and diffusion models show that LoRAGuard achieves nearly 100% watermark verification success and demonstrates strong effectiveness.

Zhiyu Mou, Yiqin Lv, Miao Xu et al.

Auto-bidding serves as a critical tool for advertisers to improve their advertising performance. Recent progress has demonstrated that AI-Generated Bidding (AIGB), which learns a conditional generative planner from offline data, achieves superior performance compared to typical offline reinforcement learning (RL)-based auto-bidding methods. However, existing AIGB methods still face a performance bottleneck due to their inherent inability to explore beyond the static offline dataset. To address this, we propose {AIGB-Pearl} (\emph{{P}lanning with {E}valu{A}tor via RL}), a novel method that integrates generative planning and policy optimization. The core of AIGB-Pearl lies in constructing a trajectory evaluator for scoring generation quality and designing a provably sound KL-Lipschitz-constrained score maximization scheme to ensure safe and efficient exploration beyond the offline dataset. A practical algorithm incorporating the synchronous coupling technique is further devised to ensure the model regularity required by the proposed scheme. Extensive experiments on both simulated and real-world advertising systems demonstrate the state-of-the-art performance of our approach.