Wen‐Yuan Chen

Wenyuan Chen, Haocong Song, Changsheng Dai et al.

Traditional sperm morphology analysis is based on tedious manual annotation. Automated morphology analysis of a high number of sperm requires accurate segmentation of each sperm part and quantitative morphology evaluation. State-of-the-art instance-aware part segmentation networks follow a "detect-then-segment" paradigm. However, due to sperm's slim shape, their segmentation suffers from large context loss and feature distortion due to bounding box cropping and resizing during ROI Align. Moreover, morphology measurement of sperm tail is demanding because of the long and curved shape and its uneven width. This paper presents automated techniques to measure sperm morphology parameters automatically and quantitatively. A novel attention-based instance-aware part segmentation network is designed to reconstruct lost contexts outside bounding boxes and to fix distorted features, by refining preliminary segmented masks through merging features extracted by feature pyramid network. An automated centerline-based tail morphology measurement method is also proposed, in which an outlier filtering method and endpoint detection algorithm are designed to accurately reconstruct tail endpoints. Experimental results demonstrate that the proposed network outperformed the state-of-the-art top-down RP-R-CNN by 9.2% [AP]_vol^p, and the proposed automated tail morphology measurement method achieved high measurement accuracies of 95.34%,96.39%,91.2% for length, width and curvature, respectively.

Jun-Teng Yang, Wen-Yuan Chen, Che-Hua Li et al.

Recent research in Internet of things has been widely applied for industrial practices, fostering the exponential growth of data and connected devices. Henceforth, data-driven AI models would be accessed by different parties through certain data-sharing policies. However, most of the current training procedures rely on the centralized data-collection strategy and a single computational server. However, such a centralized scheme may lead to many issues. Customer data stored in a centralized database may be tampered with so the provenance and authenticity of data cannot be justified. Once the aforementioned security concerns occur, the credibility of the trained AI models would be questionable and even unfavorable outcomes might be produced at the test stage. Lately, blockchain and AI, the two core technologies in Industry 4.0 and Web 3.0, have been explored to facilitate the decentralized AI training strategy. To serve on this very purpose, we propose a new system architecture called APPFLChain, namely an integrated architecture of a Hyperledger Fabric-based blockchain and a federated-learning paradigm. Our proposed new system allows different parties to jointly train AI models and their customers or stakeholders are connected by a consortium blockchain-based network. Our new system can maintain a high degree of security and privacy as users do not need to share sensitive personal information to the server. For numerical evaluation, we simulate a real-world scenario to illustrate the whole operational process of APPFLChain. Simulation results show that taking advantage of the characteristics of consortium blockchain and federated learning, APPFLChain can demonstrate favorable properties including untamperability, traceability, privacy protection, and reliable decision-making.

Wenyuan Chen, Fateme Nateghi Haredasht, Kameron C. Black et al.

Asynchronous patient-clinician messaging via EHR portals is a growing source of clinician workload, prompting interest in large language models (LLMs) to assist with draft responses. However, LLM outputs may contain clinical inaccuracies, omissions, or tone mismatches, making robust evaluation essential. Our contributions are threefold: (1) we introduce a clinically grounded error ontology comprising 5 domains and 59 granular error codes, developed through inductive coding and expert adjudication; (2) we develop a retrieval-augmented evaluation pipeline (RAEC) that leverages semantically similar historical message-response pairs to improve judgment quality; and (3) we provide a two-stage prompting architecture using DSPy to enable scalable, interpretable, and hierarchical error detection. Our approach assesses the quality of drafts both in isolation and with reference to similar past message-response pairs retrieved from institutional archives. Using a two-stage DSPy pipeline, we compared baseline and reference-enhanced evaluations on over 1,500 patient messages. Retrieval context improved error identification in domains such as clinical completeness and workflow appropriateness. Human validation on 100 messages demonstrated superior agreement (concordance = 50% vs. 33%) and performance (F1 = 0.500 vs. 0.256) of context-enhanced labels vs. baseline, supporting the use of our RAEC pipeline as AI guardrails for patient messaging.