Masked Pre-Training of Transformers for Histology Image AnalysisShuai Jiang, Liesbeth Hondelink, Arief A. Suriawinata et al.
In digital pathology, whole slide images (WSIs) are widely used for applications such as cancer diagnosis and prognosis prediction. Visual transformer models have recently emerged as a promising method for encoding large regions of WSIs while preserving spatial relationships among patches. However, due to the large number of model parameters and limited labeled data, applying transformer models to WSIs remains challenging. Inspired by masked language models, we propose a pretext task for training the transformer model without labeled data to address this problem. Our model, MaskHIT, uses the transformer output to reconstruct masked patches and learn representative histological features based on their positions and visual features. The experimental results demonstrate that MaskHIT surpasses various multiple instance learning approaches by 3% and 2% on survival prediction and cancer subtype classification tasks, respectively. Furthermore, MaskHIT also outperforms two of the most recent state-of-the-art transformer-based methods. Finally, a comparison between the attention maps generated by the MaskHIT model with pathologist's annotations indicates that the model can accurately identify clinically relevant histological structures in each task.
6.6SPAug 9, 2024
Generative AI on SpectrumNet: An Open Benchmark of Multiband 3D Radio MapsShuhang Zhang, Shuai Jiang, Wanjie Lin et al.
Radio map is an efficient demonstration for visually displaying the wireless signal coverage within a certain region. It has been considered to be increasingly helpful for the future sixth generation (6G) of wireless networks, as wireless nodes are becoming more crowded and complicated. However, the construction of high resolution radio map is very challenging due to the sparse sampling in practical systems. Generative artificial intelligence (AI), which is capable to create synthetic data to fill in gaps in real-world measurements, is an effective technique to construct high precision radio maps. Currently, generative models for radio map construction are trained with two-dimension (2D) single band radio maps in urban scenario, which has poor generalization in diverse terrain scenarios, spectrum bands, and heights. To tackle this problem, we provide a multiband three-dimension (3D) radio map dataset with consideration of terrain and climate information, named SpectrumNet. It is the largest radio map dataset in terms of dimensions and scale, which contains the radio map of 3 spacial dimensions, 5 frequency bands, 11 terrain scenarios, and 3 climate scenarios. We introduce the parameters and settings for the SpectrumNet dataset generation, and evaluate three baseline methods for radio map construction based on the SpectrumNet dataset. Experiments show the necessity of the SpectrumNet dataset for training models with strong generalization in spacial, frequency, and scenario domains. Future works on the SpectrumNet dataset are also discussed, including the dataset expansion and calibration, as well as the extended studies on generative models for radio map construction based on the SpectrumNet dataset.
Mutually Guided Few-shot Learning for Relational Triple ExtractionChengmei Yang, Shuai Jiang, Bowei He et al.
Knowledge graphs (KGs), containing many entity-relation-entity triples, provide rich information for downstream applications. Although extracting triples from unstructured texts has been widely explored, most of them require a large number of labeled instances. The performance will drop dramatically when only few labeled data are available. To tackle this problem, we propose the Mutually Guided Few-shot learning framework for Relational Triple Extraction (MG-FTE). Specifically, our method consists of an entity-guided relation proto-decoder to classify the relations firstly and a relation-guided entity proto-decoder to extract entities based on the classified relations. To draw the connection between entity and relation, we design a proto-level fusion module to boost the performance of both entity extraction and relation classification. Moreover, a new cross-domain few-shot triple extraction task is introduced. Extensive experiments show that our method outperforms many state-of-the-art methods by 12.6 F1 score on FewRel 1.0 (single-domain) and 20.5 F1 score on FewRel 2.0 (cross-domain).
4.1LGApr 13, 2025
Transformer-Based Representation Learning for Robust Gene Expression Modeling and Cancer PrognosisShuai Jiang, Saeed Hassanpour
Transformer-based models have achieved remarkable success in natural language and vision tasks, but their application to gene expression analysis remains limited due to data sparsity, high dimensionality, and missing values. We present GexBERT, a transformer-based autoencoder framework for robust representation learning of gene expression data. GexBERT learns context-aware gene embeddings by pretraining on large-scale transcriptomic profiles with a masking and restoration objective that captures co-expression relationships among thousands of genes. We evaluate GexBERT across three critical tasks in cancer research: pan-cancer classification, cancer-specific survival prediction, and missing value imputation. GexBERT achieves state-of-the-art classification accuracy from limited gene subsets, improves survival prediction by restoring expression of prognostic anchor genes, and outperforms conventional imputation methods under high missingness. Furthermore, its attention-based interpretability reveals biologically meaningful gene patterns across cancer types. These findings demonstrate the utility of GexBERT as a scalable and effective tool for gene expression modeling, with translational potential in settings where gene coverage is limited or incomplete.
0.5CLSep 3, 2023
A Visual Interpretation-Based Self-Improved Classification System Using Virtual Adversarial TrainingShuai Jiang, Sayaka Kamei, Chen Li et al.
The successful application of large pre-trained models such as BERT in natural language processing has attracted more attention from researchers. Since the BERT typically acts as an end-to-end black box, classification systems based on it usually have difficulty in interpretation and low robustness. This paper proposes a visual interpretation-based self-improving classification model with a combination of virtual adversarial training (VAT) and BERT models to address the above problems. Specifically, a fine-tuned BERT model is used as a classifier to classify the sentiment of the text. Then, the predicted sentiment classification labels are used as part of the input of another BERT for spam classification via a semi-supervised training manner using VAT. Additionally, visualization techniques, including visualizing the importance of words and normalizing the attention head matrix, are employed to analyze the relevance of each component to classification accuracy. Moreover, brand-new features will be found in the visual analysis, and classification performance will be improved. Experimental results on Twitter's tweet dataset demonstrate the effectiveness of the proposed model on the classification task. Furthermore, the ablation study results illustrate the effect of different components of the proposed model on the classification results.