Yihang Liu

Yihang Liu, Ying Wen, Jiaxiong Yang et al.

Medical foundation models (MFMs) aim to learn universal representations from multimodal medical images that can generalize effectively to diverse downstream clinical tasks. However, most existing MFMs suffer from information ambiguity that blend multimodal representations in a single embedding space, leading to the degradation of modality specificity and diversity. In this paper, we propose M-IDoL, a self-supervised \underline{\textit{M}}FM that introduces Information Decomposition for multimodal representation Learning via two objectives: i) maximize inter-modality entropy by dispersing multimodal representation into separable Mixture-of-Experts (MoE) subspaces to achieve representation specificity across modalities; and ii) minimize intra-modality uncertainty by performing fine-grained semantic discrimination within each MoE subspace to enrich representation diversity per modality. By pre-training on 1.15 million medical images, M-IDoL i) delivers superior generalization across 21 downstream clinical tasks, outperforming 20 foundation models on five imaging modalities (e.g., X-ray, fundus, OCT, dermoscopy and pathology), and ii) learns modality-specific and diverse representations, showing clearer separation of feature cluster across modalities and finer-grained feature discrimination within each modality.

Longzhen Yang, Yihang Liu, Yitao Peng et al.

Accuracy and Diversity are two essential metrizable manifestations in generating natural and semantically correct captions. Many efforts have been made to enhance one of them with another decayed due to the trade-off gap. In this work, we will show that the inferior standard of accuracy draws from human annotations (leave-one-out) are not appropriate for machine-generated captions. To improve diversity with a solid accuracy performance, we exploited a novel Variational Transformer framework. By introducing the "Invisible Information Prior" and the "Auto-selectable GMM", we instruct the encoder to learn the precise language information and object relation in different scenes for accuracy assurance. By introducing the "Range-Median Reward" baseline, we retain more diverse candidates with higher rewards during the RL-based training process for diversity assurance. Experiments show that our method achieves the simultaneous promotion of accuracy (CIDEr) and diversity (self-CIDEr), up to 1.1 and 4.8 percent. Also, our method got the most similar performance of the semantic retrieval compared to human annotations, with 50.3 (50.6 of human) for R@1(i2t).

Yitao Peng, Longzhen Yang, Yihang Liu et al.

Saliency methods generating visual explanatory maps representing the importance of image pixels for model classification is a popular technique for explaining neural network decisions. Hierarchical dynamic masks (HDM), a novel explanatory maps generation method, is proposed in this paper to enhance the granularity and comprehensiveness of saliency maps. First, we suggest the dynamic masks (DM), which enables multiple small-sized benchmark mask vectors to roughly learn the critical information in the image through an optimization method. Then the benchmark mask vectors guide the learning of large-sized auxiliary mask vectors so that their superimposed mask can accurately learn fine-grained pixel importance information and reduce the sensitivity to adversarial perturbations. In addition, we construct the HDM by concatenating DM modules. These DM modules are used to find and fuse the regions of interest in the remaining neural network classification decisions in the mask image in a learning-based way. Since HDM forces DM to perform importance analysis in different areas, it makes the fused saliency map more comprehensive. The proposed method outperformed previous approaches significantly in terms of recognition and localization capabilities when tested on natural and medical datasets.

Hongzhou Chen, Lianghua He, Yihang Liu et al.

Visual neural decoding refers to the process of extracting and interpreting original visual experiences from human brain activity. Recent advances in metric learning-based EEG visual decoding methods have delivered promising results and demonstrated the feasibility of decoding novel visual categories from brain activity. However, methods that directly map EEG features to the CLIP embedding space may introduce mapping bias and cause semantic inconsistency among features, thereby degrading alignment and impairing decoding performance. To further explore the semantic consistency between visual and neural signals. In this work, we construct a joint semantic space and propose a Visual-EEG Semantic Decouple Framework that explicitly extracts the semantic-related features of these two modalities to facilitate optimal alignment. Specifically, a cross-modal information decoupling module is introduced to guide the extraction of semantic-related information from modalities. Then, by quantifying the mutual information between visual image and EEG features, we observe a strong positive correlation between the decoding performance and the magnitude of mutual information. Furthermore, inspired by the mechanisms of visual object understanding from neuroscience, we propose an intra-class geometric consistency approach during the alignment process. This strategy maps visual samples within the same class to consistent neural patterns, which further enhances the robustness and the performance of EEG visual decoding. Experiments on a large Image-EEG dataset show that our method achieves state-of-the-art results in zero-shot neural decoding tasks.

Yitao Peng, Yihang Liu, Longzhen Yang et al.

The interpretability of neural networks has recently received extensive attention. Previous prototype-based explainable networks involved prototype activation in both reasoning and interpretation processes, requiring specific explainable structures for the prototype, thus making the network less accurate as it gains interpretability. Therefore, the decoupling prototypical network (DProtoNet) was proposed to avoid this problem. This new model contains encoder, inference, and interpretation modules. As regards the encoder module, unrestricted feature masks were presented to generate expressive features and prototypes. Regarding the inference module, a multi-image prototype learning method was introduced to update prototypes so that the network can learn generalized prototypes. Finally, concerning the interpretation module, a multiple dynamic masks (MDM) decoder was suggested to explain the neural network, which generates heatmaps using the consistent activation of the original image and mask image at the detection nodes of the network. It decouples the inference and interpretation modules of a prototype-based network by avoiding the use of prototype activation to explain the network's decisions in order to simultaneously improve the accuracy and interpretability of the neural network. The multiple public general and medical datasets were tested, and the results confirmed that our method could achieve a 5% improvement in accuracy and state-of-the-art interpretability compared with previous methods.

Yizhe Yang, Heyan Huang, Yihang Liu et al.

Knowledge-grounded dialogue is a task of generating an informative response based on both the dialogue history and external knowledge source. In general, there are two forms of knowledge: manually annotated knowledge graphs and knowledge text from website. From various evaluation viewpoints, each type of knowledge has advantages and downsides. To further distinguish the principles and determinants from the intricate factors, we conduct a thorough experiment and study on the task to answer three essential questions. The questions involve the choice of appropriate knowledge form, the degree of mutual effects between knowledge and the model selection, and the few-shot performance of knowledge. Supported by statistical shreds of evidence, we offer conclusive solutions and sensible suggestions for directions and standards of future research.

Longzhen Yang, Zhangkai Ni, Ying Wen et al.

Vision-grounded medical report generation aims to produce clinically accurate descriptions of medical images, anchored in explicit visual evidence to improve interpretability and facilitate integration into clinical workflows. However, existing methods often rely on separately trained detection modules that require extensive expert annotations, introducing high labeling costs and limiting generalizability due to pathology distribution bias across datasets. To address these challenges, we propose Self-Supervised Anatomical Consistency Learning (SS-ACL) -- a novel and annotation-free framework that aligns generated reports with corresponding anatomical regions using simple textual prompts. SS-ACL constructs a hierarchical anatomical graph inspired by the invariant top-down inclusion structure of human anatomy, organizing entities by spatial location. It recursively reconstructs fine-grained anatomical regions to enforce intra-sample spatial alignment, inherently guiding attention maps toward visually relevant areas prompted by text. To further enhance inter-sample semantic alignment for abnormality recognition, SS-ACL introduces a region-level contrastive learning based on anatomical consistency. These aligned embeddings serve as priors for report generation, enabling attention maps to provide interpretable visual evidence. Extensive experiments demonstrate that SS-ACL, without relying on expert annotations, (i) generates accurate and visually grounded reports -- outperforming state-of-the-art methods by 10\% in lexical accuracy and 25\% in clinical efficacy, and (ii) achieves competitive performance on various downstream visual tasks, surpassing current leading visual foundation models by 8\% in zero-shot visual grounding.

Andrew J. Loza, Jun Yup Kim, Shangzheng Song et al.

Real-world processes often generate data that are a mix of categorical and numeric values that are recorded at irregular and informative intervals. Discrete token-based approaches are limited in numeric representation capacity while methods like neural ordinary differential equations are not well suited for categorical data or informative sampling and require augmentation to handle certain classes of trajectories. Here, we present multivariateGPT, a single architecture for modeling sequences of mixed categorical (including tokenized text) and numeric data. This is accomplished with an autoregressive sequence decomposition, embedding scheme, and loss function that extend the next token prediction task to likelihood estimation of the joint distribution of next token class and value. We demonstrate how this approach can efficiently learn to generalize patterns in simple physical systems and model complex time series including electrocardiograms and multivariate electronic health record data. This work extends the utility of transformer based models to additional classes of data.

Yitao Peng, Lianghua He, Die Hu et al.

Interpretable deep learning models have received widespread attention in the field of image recognition. Due to the unique multi-instance learning of medical images and the difficulty in identifying decision-making regions, many interpretability models that have been proposed still have problems of insufficient accuracy and interpretability in medical image disease diagnosis. To solve these problems, we propose feature-driven inference network (FeaInfNet). Our first key innovation involves proposing a feature-based network reasoning structure, which is applied to FeaInfNet. The network of this structure compares the similarity of each sub-region image patch with the disease templates and normal templates that may appear in the region, and finally combines the comparison of each sub-region to make the final diagnosis. It simulates the diagnosis process of doctors to make the model interpretable in the reasoning process, while avoiding the misleading caused by the participation of normal areas in reasoning. Secondly, we propose local feature masks (LFM) to extract feature vectors in order to provide global information for these vectors, thus enhancing the expressive ability of the FeaInfNet. Finally, we propose adaptive dynamic masks (Adaptive-DM) to interpret feature vectors and prototypes into human-understandable image patches to provide accurate visual interpretation. We conducted qualitative and quantitative experiments on multiple publicly available medical datasets, including RSNA, iChallenge-PM, Covid-19, ChinaCXRSet, and MontgomerySet. The results of our experiments validate that our method achieves state-of-the-art performance in terms of classification accuracy and interpretability compared to baseline methods in medical image diagnosis. Additional ablation studies verify the effectiveness of each of our proposed components.