Lantian Zhang

Taiping Qu, Hongkai Zhang, Lantian Zhang et al.

Cardiac magnetic resonance (CMR) is a cornerstone for diagnosing cardiovascular disease. However, it remains underutilized due to complex, time-consuming interpretation across multi-sequences, phases, quantitative measures that heavily reliant on specialized expertise. Here, we present BAAI Cardiac Agent, a multimodal intelligent system designed for end-to-end CMR interpretation. The agent integrates specialized cardiac expert models to perform automated segmentation of cardiac structures, functional quantification, tissue characterization and disease diagnosis, and generates structured clinical reports within a unified workflow. Evaluated on CMR datasets from two hospitals (2413 patients) spanning 7-types of major cardiovascular diseases, the agent achieved an area under the receiver-operating-characteristic curve exceeding 0.93 internally and 0.81 externally. In the task of estimating left ventricular function indices, the results generated by this system for core parameters such as ejection fraction, stroke volume, and left ventricular mass are highly consistent with clinical reports, with Pearson correlation coefficients all exceeding 0.90. The agent outperformed state-of-the-art models in segmentation and diagnostic tasks, and generated clinical reports showing high concordance with expert radiologists (six readers across three experience levels). By dynamically orchestrating expert models for coordinated multimodal analysis, this agent framework enables accurate, efficient CMR interpretation and highlights its potentials for complex clinical imaging workflows. Code is available at https://github.com/plantain-herb/Cardiac-Agent.

Lantian Zhang, Lei Guo

As saturated output observations are ubiquitous in practice, identifying stochastic systems with such nonlinear observations is a fundamental problem across various fields. This paper investigates the asymptotically efficient identification problem for stochastic dynamical systems with saturated output observations. In contrast to most of the existing results, our results do not need the commonly used but stringent conditions such as periodic or independent assumptions on the system signals, and thus do not exclude applications to stochastic feedback systems. To be specific, we introduce a new adaptive Newton-type algorithm on the negative log-likelihood of the partially observed samples using a two-step design technique. Under some general excitation data conditions, we show that the parameter estimate is strongly consistent and asymptotically normal by employing the stochastic Lyapunov function method and limit theories for martingales. Furthermore, we show that the mean square error of the estimates can achieve the Cramer-Rao bound asymptotically without resorting to i.i.d data assumptions. This indicates that the performance of the proposed algorithm is the best possible that one can expect in general. A numerical example is provided to illustrate the superiority of our new adaptive algorithm over the existing related ones in the literature.

Lantian Zhang, Mohamed Amgad, Lee A. D. Cooper

Data labeling is often the most challenging task when developing computational pathology models. Pathologist participation is necessary to generate accurate labels, and the limitations on pathologist time and demand for large, labeled datasets has led to research in areas including weakly supervised learning using patient-level labels, machine assisted annotation and active learning. In this paper we explore self-supervised learning to reduce labeling burdens in computational pathology. We explore this in the context of classification of breast cancer tissue using the Barlow Twins approach, and we compare self-supervision with alternatives like pre-trained networks in low-data scenarios. For the task explored in this paper, we find that ImageNet pre-trained networks largely outperform the self-supervised representations obtained using Barlow Twins.

Lantian Zhang, Yanlong Zhao, Lei Guo

Dynamical systems with binary-valued observations are widely used in information industry, technology of biological pharmacy and other fields. Though there have been much efforts devoted to the identification of such systems, most of the previous investigations are based on first-order gradient algorithm which usually has much slower convergence rate than the Quasi-Newton algorithm. Moreover, persistence of excitation(PE) conditions are usually required to guarantee consistent parameter estimates in the existing literature, which are hard to be verified or guaranteed for feedback control systems. In this paper, we propose an online projected Quasi-Newton type algorithm for parameter estimation of stochastic regression models with binary-valued observations and varying thresholds. By using both the stochastic Lyapunov function and martingale estimation methods, we establish the strong consistency of the estimation algorithm and provide the convergence rate, under a signal condition which is considerably weaker than the traditional PE condition and coincides with the weakest possible excitation known for the classical least square algorithm of stochastic regression models. Convergence of adaptive predictors and their applications in adaptive control are also discussed.