Huajun Zhou

Huajun Zhou, Bo Qiao, Lingxiao Yang et al.

Deep Learning-based Unsupervised Salient Object Detection (USOD) mainly relies on the noisy saliency pseudo labels that have been generated from traditional handcraft methods or pre-trained networks. To cope with the noisy labels problem, a class of methods focus on only easy samples with reliable labels but ignore valuable knowledge in hard samples. In this paper, we propose a novel USOD method to mine rich and accurate saliency knowledge from both easy and hard samples. First, we propose a Confidence-aware Saliency Distilling (CSD) strategy that scores samples conditioned on samples' confidences, which guides the model to distill saliency knowledge from easy samples to hard samples progressively. Second, we propose a Boundary-aware Texture Matching (BTM) strategy to refine the boundaries of noisy labels by matching the textures around the predicted boundary. Extensive experiments on RGB, RGB-D, RGB-T, and video SOD benchmarks prove that our method achieves state-of-the-art USOD performance.

Yingxue Xu, Zhengyu Zhang, Xiuming Zhang et al.

Pathology foundation models have shown strong retrospective performance, but whether such systems can support clinically relevant use remains unclear. This challenge is particularly important in breast cancer, where pathological assessment serves as the gold standard for diagnosis and guides treatment planning, surgical decision-making and risk stratification across pre-, intra- and post-operative stages. Here we present \textbf{BRAVE}, a breast-adaptive pathology foundation model developed and evaluated using a total resource of 101,638 breast whole-slide images from 32 sources across Asia, Europe and North America. We assessed BRAVE across 34 tasks in 82 cohorts spanning pre-operative biopsy, intra-operative frozen section and post-operative resection, using an evidence chain comprising retrospective benchmarking, clinically challenging scenarios, workflow-oriented clinical impact simulations, prospective observational validation with the thresholds locked in the retrospective cohorts and crossover pathologist-AI interaction studies. Across these settings, BRAVE supported practical roles in the clinical workflow, including safe exclusion of low-risk cases from routine review, AI-assisted second-review rescue of initially missed positives and prioritization of cases for further assessment. In prospective validation across three centres, BRAVE excluded 76.9% of negative biopsy cases (NPV 0.953) and 70.1% of negative frozen-section cases (NPV 0.973), and triaged 78.8% of post-operative subtyping cases as high-confidence clear-cut cases (NPV 1.000). In reader studies, AI assistance improved balanced accuracy from 88.5% to 95.1% (OR 3.14, P<0.001), with better efficiency, confidence and inter-rater agreement. BRAVE-derived scores also independently predicted disease-free survival (adjusted HR 4.79, P<0.001) and overall survival (adjusted HR 8.14, P<0.001).

Jiabo Ma, Cheng Jin, Yihui Wang et al.

Computational pathology has advanced rapidly with the emergence of foundation models, yet widespread adoption remains limited by substantial technical complexity and programming requirements. Here we present PathLab, an autonomous agentic framework that translates natural-language research objectives into executable and validated computational pathology workflows through the structured composition of domain-specific skills and tools. By organizing workflow generation around reusable methodological modules, including data preprocessing, model development, evaluation and interpretation, PathLab enables studies to be specified at the level of scientific intent rather than implementation details. We evaluated PathLab across 12 public datasets spanning four representative task families: region-of-interest classification, whole-slide image classification, segmentation and survival prediction. Across all task categories, PathLab achieved non-inferior performance relative to expert implementations, while consistently enforcing semantic validity of user prompts and proactively rejecting incompatible workflow specifications prior to execution. In controlled user studies, PathLab substantially reduced the time required to generate executable analytical pipelines and enabled domain experts without programming experience to independently design, execute and evaluate computational pathology studies. Together, these results establish PathLab as a reliable interface between biomedical intent and computational execution, enabling computational pathology studies to be designed at the level of scientific questions rather than programming expertise. By lowering technical barriers to advanced AI methodologies, PathLab provides a foundation for the broader democratization of computational pathology.

Huajun Zhou, Yang Lin, Lingxiao Yang et al.

In recent years, deep network-based methods have continuously refreshed state-of-the-art performance on Salient Object Detection (SOD) task. However, the performance discrepancy caused by different implementation details may conceal the real progress in this task. Making an impartial comparison is required for future researches. To meet this need, we construct a general SALient Object Detection (SALOD) benchmark to conduct a comprehensive comparison among several representative SOD methods. Specifically, we re-implement 14 representative SOD methods by using consistent settings for training. Moreover, two additional protocols are set up in our benchmark to investigate the robustness of existing methods in some limited conditions. In the first protocol, we enlarge the difference between objectness distributions of train and test sets to evaluate the robustness of these SOD methods. In the second protocol, we build multiple train subsets with different scales to validate whether these methods can extract discriminative features from only a few samples. In the above experiments, we find that existing loss functions usually specialized in some metrics but reported inferior results on the others. Therefore, we propose a novel Edge-Aware (EA) loss that promotes deep networks to learn more discriminative features by integrating both pixel- and image-level supervision signals. Experiments prove that our EA loss reports more robust performances compared to existing losses.

Huajun Zhou, Peijia Chen, Lingxiao Yang et al.

Existing deep learning-based Unsupervised Salient Object Detection (USOD) methods rely on supervised pre-trained deep models. Moreover, they generate pseudo labels based on hand-crafted features, which lack high-level semantic information. In order to overcome these shortcomings, we propose a new two-stage Activation-to-Saliency (A2S) framework that effectively excavates high-quality saliency cues to train a robust saliency detector. It is worth noting that our method does not require any manual annotation, even in the pre-training phase. In the first stage, we transform an unsupervisedly pre-trained network to aggregate multi-level features to a single activation map, where an Adaptive Decision Boundary (ADB) is proposed to assist the training of the transformed network. Moreover, a new loss function is proposed to facilitate the generation of high-quality pseudo labels. In the second stage, a self-rectification learning paradigm strategy is developed to train a saliency detector and refine the pseudo labels online. In addition, we construct a lightweight saliency detector using two Residual Attention Modules (RAMs) to largely reduce the risk of overfitting. Extensive experiments on several SOD benchmarks prove that our framework reports significant performance compared with existing USOD methods. Moreover, training our framework on 3,000 images consumes about 1 hour, which is over 30$\times$ faster than previous state-of-the-art methods.

Peijia Chen, Jianhuang Lai, Guangcong Wang et al.

Video salient object detection (VSOD) aims to locate and segment the most attractive object by exploiting both spatial cues and temporal cues hidden in video sequences. However, spatial and temporal cues are often unreliable in real-world scenarios, such as low-contrast foreground, fast motion, and multiple moving objects. To address these problems, we propose a new framework to adaptively capture available information from spatial and temporal cues, which contains Confidence-guided Adaptive Gate (CAG) modules and Dual Differential Enhancement (DDE) modules. For both RGB features and optical flow features, CAG estimates confidence scores supervised by the IoU between predictions and the ground truths to re-calibrate the information with a gate mechanism. DDE captures the differential feature representation to enrich the spatial and temporal information and generate the fused features. Experimental results on four widely used datasets demonstrate the effectiveness of the proposed method against thirteen state-of-the-art methods.

Zixuan Chen, Huajun Zhou, Xiaohua Xie et al.

We present a learning model that makes full use of boundary information for salient object segmentation. Specifically, we come up with a novel loss function, i.e., Contour Loss, which leverages object contours to guide models to perceive salient object boundaries. Such a boundary-aware network can learn boundary-wise distinctions between salient objects and background, hence effectively facilitating the saliency detection. Yet the Contour Loss emphasizes on the local saliency. We further propose the hierarchical global attention module (HGAM), which forces the model hierarchically attend to global contexts, thus captures the global visual saliency. Comprehensive experiments on six benchmark datasets show that our method achieves superior performance over state-of-the-art ones. Moreover, our model has a real-time speed of 26 fps on a TITAN X GPU.