Junjie Bai

Zhihui Guo, Junjie Bai, Yi Lu et al.

A novel centerline extraction framework is reported which combines an end-to-end trainable multi-task fully convolutional network (FCN) with a minimal path extractor. The FCN simultaneously computes centerline distance maps and detects branch endpoints. The method generates single-pixel-wide centerlines with no spurious branches. It handles arbitrary tree-structured object with no prior assumption regarding depth of the tree or its bifurcation pattern. It is also robust to substantial scale changes across different parts of the target object and minor imperfections of the object's segmentation mask. To the best of our knowledge, this is the first deep-learning based centerline extraction method that guarantees single-pixel-wide centerline for a complex tree-structured object. The proposed method is validated in coronary artery centerline extraction on a dataset of 620 patients (400 of which used as test set). This application is challenging due to the large number of coronary branches, branch tortuosity, and large variations in length, thickness, shape, etc. The proposed method generates well-positioned centerlines, exhibiting lower number of missing branches and is more robust in the presence of minor imperfections of the object segmentation mask. Compared to a state-of-the-art traditional minimal path approach, our method improves patient-level success rate of centerline extraction from 54.3% to 88.8% according to independent human expert review.

Junjie Bai, Abhay Shah, Xiaodong Wu

Shape priors have been widely utilized in medical image segmentation to improve segmentation accuracy and robustness. A major way to encode such a prior shape model is to use a mesh representation, which is prone to causing self-intersection or mesh folding. Those problems require complex and expensive algorithms to mitigate. In this paper, we propose a novel shape prior directly embedded in the voxel grid space, based on gradient vector flows of a pre-segmentation. The flexible and powerful prior shape representation is ready to be extended to simultaneously segmenting multiple interacting objects with minimum separation distance constraint. The problem is formulated as a Markov random field problem whose exact solution can be efficiently computed with a single minimum s-t cut in an appropriately constructed graph. The proposed algorithm is validated on two multi-object segmentation applications: the brain tissue segmentation in MRI images, and the bladder/prostate segmentation in CT images. Both sets of experiments show superior or competitive performance of the proposed method to other state-of-the-art methods.