Yiran Wei

Siddharth Agarwal, David Wood, Robin Carpenter et al.

This letter critically examines the recent article by Infante et al. assessing the utility of large language models (LLMs) like GPT-4, Perplexity, and Bard in identifying urgent findings in emergency radiology reports. While acknowledging the potential of LLMs in generating labels for computer vision, concerns are raised about the ethical implications of using patient data without explicit approval, highlighting the necessity of stringent data protection measures under GDPR.

Chao Li, Yiran Wei, Xi Chen et al.

Alzheimer's disease (AD) is the most common age-related dementia. It remains a challenge to identify the individuals at risk of dementia for precise management. Brain MRI offers a noninvasive biomarker to detect brain aging. Previous evidence shows that the brain structural change detected by diffusion MRI is associated with dementia. Mounting studies has conceptualised the brain as a complex network, which has shown the utility of this approach in characterising various neurological and psychiatric disorders. Therefore, the structural connectivity shows promise in dementia classification. The proposed BrainNetGAN is a generative adversarial network variant to augment the brain structural connectivity matrices for binary dementia classification tasks. Structural connectivity matrices between separated brain regions are constructed using tractography on diffusion MRI data. The BrainNetGAN model is trained to generate fake brain connectivity matrices, which are expected to reflect latent distribution of the real brain network data. Finally, a convolutional neural network classifier is proposed for binary dementia classification. Numerical results show that the binary classification performance in the testing set was improved using the BrainNetGAN augmented dataset. The proposed methodology allows quick synthesis of an arbitrary number of augmented connectivity matrices and can be easily transferred to similar classification tasks.

Chao Li, Wenjian Huang, Xi Chen et al.

We present an Expectation-Maximization (EM) Regularized Deep Learning (EMReDL) model for weakly supervised tumor segmentation. The proposed framework is tailored to glioblastoma, a type of malignant tumor characterized by its diffuse infiltration into the surrounding brain tissue, which poses significant challenge to treatment target and tumor burden estimation using conventional structural MRI. Although physiological MRI provides more specific information regarding tumor infiltration, the relatively low resolution hinders a precise full annotation. This has motivated us to develop a weakly supervised deep learning solution that exploits the partial labelled tumor regions. EMReDL contains two components: a physiological prior prediction model and EM-regularized segmentation model. The physiological prior prediction model exploits the physiological MRI by training a classifier to generate a physiological prior map. This map is passed to the segmentation model for regularization using the EM algorithm. We evaluated the model on a glioblastoma dataset with the pre-operative multiparametric and recurrence MRI available. EMReDL showed to effectively segment the infiltrated tumor from the partially labelled region of potential infiltration. The segmented core tumor and infiltrated tumor demonstrated high consistency with the tumor burden labelled by experts. The performance comparisons showed that EMReDL achieved higher accuracy than published state-of-the-art models. On MR spectroscopy, the segmented region displayed more aggressive features than other partial labelled region. The proposed model can be generalized to other segmentation tasks that rely on partial labels, with the CNN architecture flexible in the framework.