Tong Chen

Jing Zhang, Yanjun Lyu, Xiaowei Yu et al.

Dynamic functional connectivity (dFC) using resting-state functional magnetic resonance imaging (rs-fMRI) is an advanced technique for capturing the dynamic changes of neural activities, and can be very useful in the studies of brain diseases such as Alzheimer's disease (AD). Yet, existing studies have not fully leveraged the sequential information embedded within dFC that can potentially provide valuable information when identifying brain conditions. In this paper, we propose a novel framework that jointly learns the embedding of both spatial and temporal information within dFC based on the transformer architecture. Specifically, we first construct dFC networks from rs-fMRI data through a sliding window strategy. Then, we simultaneously employ a temporal block and a spatial block to capture higher-order representations of dynamic spatio-temporal dependencies, via mapping them into an efficient fused feature representation. To further enhance the robustness of these feature representations by reducing the dependency on labeled data, we also introduce a contrastive learning strategy to manipulate different brain states. Experimental results on 345 subjects with 570 scans from the Alzheimer's Disease Neuroimaging Initiative (ADNI) demonstrate the superiority of our proposed method for MCI (Mild Cognitive Impairment, the prodromal stage of AD) prediction, highlighting its potential for early identification of AD.

Xiaowei Yu, Jing Zhang, Tong Chen et al.

Lewy Body Disease (LBD) is a common yet understudied form of dementia that imposes a significant burden on public health. It shares clinical similarities with Alzheimer's disease (AD), as both progress through stages of normal cognition, mild cognitive impairment, and dementia. A major obstacle in LBD diagnosis is data scarcity, which limits the effectiveness of deep learning. In contrast, AD datasets are more abundant, offering potential for knowledge transfer. However, LBD and AD data are typically collected from different sites using different machines and protocols, resulting in a distinct domain shift. To effectively leverage AD data while mitigating domain shift, we propose a Transferability Aware Transformer (TAT) that adapts knowledge from AD to enhance LBD diagnosis. Our method utilizes structural connectivity (SC) derived from structural MRI as training data. Built on the attention mechanism, TAT adaptively assigns greater weights to disease-transferable features while suppressing domain-specific ones, thereby reducing domain shift and improving diagnostic accuracy with limited LBD data. The experimental results demonstrate the effectiveness of TAT. To the best of our knowledge, this is the first study to explore domain adaptation from AD to LBD under conditions of data scarcity and domain shift, providing a promising framework for domain-adaptive diagnosis of rare diseases.

Minheng Chen, Chao Cao, Tong Chen et al.

The 3-hinge gyrus (3HG) is a newly defined folding pattern, which is the conjunction of gyri coming from three directions in cortical folding. Many studies demonstrated that 3HGs can be reliable nodes when constructing brain networks or connectome since they simultaneously possess commonality and individuality across different individual brains and populations. However, 3HGs are identified and validated within individual spaces, making it difficult to directly serve as the brain network nodes due to the absence of cross-subject correspondence. The 3HG correspondences represent the intrinsic regulation of brain organizational architecture, traditional image-based registration methods tend to fail because individual anatomical properties need to be fully respected. To address this challenge, we propose a novel self-supervised framework for anatomical feature embedding of the 3HGs to build the correspondences among different brains. The core component of this framework is to construct a structural similarity-enhanced multi-hop feature encoding strategy based on the recently developed Kolmogorov-Arnold network (KAN) for anatomical feature embedding. Extensive experiments suggest that our approach can effectively establish robust cross-subject correspondences when no one-to-one mapping exists.

Haike Xu, Tong Chen

The widely used retrieve-and-rerank pipeline faces two critical limitations: they are constrained by the initial retrieval quality of the top-k documents, and the growing computational demands of LLM-based rerankers restrict the number of documents that can be effectively processed. We introduce Reranker-Guided-Search (RGS), a novel approach that bypasses these limitations by directly retrieving documents according to reranker preferences rather than following the traditional sequential reranking method. Our method uses a greedy search on proximity graphs generated by approximate nearest neighbor algorithms, strategically prioritizing promising documents for reranking based on document similarity. Experimental results demonstrate substantial performance improvements across multiple benchmarks: 3.5 points on BRIGHT, 2.9 on FollowIR, and 5.1 on M-BEIR, all within a constrained reranker budget of 100 documents. Our analysis suggests that, given a fixed pair of embedding and reranker models, strategically selecting documents to rerank can significantly improve retrieval accuracy under limited reranker budget.

Jing Zhang, Xiaowei Yu, Minheng Chen et al.

Integrating brain imaging data with clinical reports offers a valuable opportunity to leverage complementary multimodal information for more effective and timely diagnosis in practical clinical settings. This approach has gained significant attention in brain disorder research, yet a key challenge remains: how to effectively link objective imaging data with subjective text-based reports, such as doctors' notes. In this work, we propose a novel framework that aligns brain connectomes with clinical reports in a shared cross-modal latent space at both the subject and connectome levels, thereby enhancing representation learning. The key innovation of our approach is that we treat brain subnetworks as tokens of imaging data, rather than raw image patches, to align with word tokens in clinical reports. This enables a more efficient identification of system-level associations between neuroimaging findings and clinical observations, which is critical since brain disorders often manifest as network-level abnormalities rather than isolated regional alterations. We applied our method to mild cognitive impairment (MCI) using the ADNI dataset. Our approach not only achieves state-of-the-art predictive performance but also identifies clinically meaningful connectome-text pairs, offering new insights into the early mechanisms of Alzheimer's disease and supporting the development of clinically useful multimodal biomarkers.

Yang Li, Tong Chen, Zi Huang

Modelling mix-and-match relationships among fashion items has become increasingly demanding yet challenging for modern E-commerce recommender systems. When performing clothes matching, most existing approaches leverage the latent visual features extracted from fashion item images for compatibility modelling, which lacks explainability of generated matching results and can hardly convince users of the recommendations. Though recent methods start to incorporate pre-defined attribute information (e.g., colour, style, length, etc.) for learning item representations and improving the model interpretability, their utilisation of attribute information is still mainly reserved for enhancing the learned item representations and generating explanations via post-processing. As a result, this creates a severe bottleneck when we are trying to advance the recommendation accuracy and generating fine-grained explanations since the explicit attributes have only loose connections to the actual recommendation process. This work aims to tackle the explainability challenge in fashion recommendation tasks by proposing a novel Attribute-aware Fashion Recommender (AFRec). Specifically, AFRec recommender assesses the outfit compatibility by explicitly leveraging the extracted attribute-level representations from each item's visual feature. The attributes serve as the bridge between two fashion items, where we quantify the affinity of a pair of items through the learned compatibility between their attributes. Extensive experiments have demonstrated that, by making full use of the explicit attributes in the recommendation process, AFRec is able to achieve state-of-the-art recommendation accuracy and generate intuitive explanations at the same time.