Sungyoung Lee

Sungyoung Lee, Ziyi Wang, Seunggeun Kim et al.

Pretraining models with unsupervised graph representation learning has led to significant advancements in domains such as social network analysis, molecular design, and electronic design automation (EDA). However, prior work in EDA has mainly focused on pretraining models for digital circuits, overlooking analog and mixed-signal circuits. To bridge this gap, we introduce DICE, a Device-level Integrated Circuits Encoder, which is the first graph neural network (GNN) pretrained via self-supervised learning specifically tailored for graph-level prediction tasks in both analog and digital circuits. DICE adopts a simulation-free pretraining approach based on graph contrastive learning, leveraging two novel graph augmentation techniques. Experimental results demonstrate substantial performance improvements across three downstream tasks, highlighting the effectiveness of DICE for both analog and digital circuits. The code is available at github.com/brianlsy98/DICE.

Yao Lai, Sungyoung Lee, Guojin Chen et al. · tsinghua

Analog circuit design is a significant task in modern chip technology, focusing on the selection of component types, connectivity, and parameters to ensure proper circuit functionality. Despite advances made by Large Language Models (LLMs) in digital circuit design, the complexity and scarcity of data in analog circuitry pose significant challenges. To mitigate these issues, we introduce AnalogCoder, the first training-free LLM agent for designing analog circuits through Python code generation. Firstly, AnalogCoder incorporates a feedback-enhanced flow with tailored domain-specific prompts, enabling the automated and self-correcting design of analog circuits with a high success rate. Secondly, it proposes a circuit tool library to archive successful designs as reusable modular sub-circuits, simplifying composite circuit creation. Thirdly, extensive experiments on a benchmark designed to cover a wide range of analog circuit tasks show that AnalogCoder outperforms other LLM-based methods. It has successfully designed 20 circuits, 5 more than standard GPT-4o. We believe AnalogCoder can significantly improve the labor-intensive chip design process, enabling non-experts to design analog circuits efficiently.

Yao Lai, Souradip Poddar, Sungyoung Lee et al. · tsinghua

Despite recent advances, analog front-end design still relies heavily on expert intuition and iterative simulations, which limits the potential for automation. We present AnalogCoder-Pro, a multimodal large language model (LLM) framework that integrates generative and optimization techniques. The framework features a multimodal diagnosis-and-repair feedback loop that uses simulation error messages and waveform images to autonomously correct design errors. It also builds a reusable circuit tool library by archiving successful designs as modular subcircuits, accelerating the development of complex systems. Furthermore, it enables end-to-end automation by generating circuit topologies from target specifications, extracting key parameters, and applying Bayesian optimization for device sizing. On a curated benchmark suite covering 13 circuit types, AnalogCoder-Pro successfully designed 28 circuits and consistently outperformed existing LLM-based methods in figures of merit.

Musarrat Hussain, Jamil Hussain, Taqdir Ali et al.

Background and Objectives: Clinical Practice Guidelines (CPGs) represent the foremost methodology for sharing state-of-the-art research findings in the healthcare domain with medical practitioners to limit practice variations, reduce clinical cost, improve the quality of care, and provide evidence based treatment. However, extracting relevant knowledge from the plethora of CPGs is not feasible for already burdened healthcare professionals, leading to large gaps between clinical findings and real practices. It is therefore imperative that state-of-the-art Computing research, especially machine learning is used to provide artificial intelligence based solution for extracting the knowledge from CPGs and reducing the gap between healthcare research/guidelines and practice. Methods: This research presents a novel methodology for knowledge extraction from CPGs to reduce the gap and turn the latest research findings into clinical practice. First, our system classifies the CPG sentences into four classes such as condition-action, condition-consequences, action, and not-applicable based on the information presented in a sentence. We use deep learning with state-of-the-art word embedding, improved word vectors technique in classification process. Second, it identifies qualifier terms in the classified sentences, which assist in recognizing the condition and action phrases in a sentence. Finally, the condition and action phrase are processed and transformed into plain rule If Condition(s) Then Action format. Results: We evaluate the methodology on three different domains guidelines including Hypertension, Rhinosinusitis, and Asthma. The deep learning model classifies the CPG sentences with an accuracy of 95%. While rule extraction was validated by user-centric approach, which achieved a Jaccard coefficient of 0.6, 0.7, and 0.4 with three human experts extracted rules, respectively.

Musarrat Hussain, Fahad Ahmed Satti, Jamil Hussain et al.

Objective: Causality mining is an active research area, which requires the application of state-of-the-art natural language processing techniques. In the healthcare domain, medical experts create clinical text to overcome the limitation of well-defined and schema driven information systems. The objective of this research work is to create a framework, which can convert clinical text into causal knowledge. Methods: A practical approach based on term expansion, phrase generation, BERT based phrase embedding and semantic matching, semantic enrichment, expert verification, and model evolution has been used to construct a comprehensive causality mining framework. This active transfer learning based framework along with its supplementary services, is able to extract and enrich, causal relationships and their corresponding entities from clinical text. Results: The multi-model transfer learning technique when applied over multiple iterations, gains performance improvements in terms of its accuracy and recall while keeping the precision constant. We also present a comparative analysis of the presented techniques with their common alternatives, which demonstrate the correctness of our approach and its ability to capture most causal relationships. Conclusion: The presented framework has provided cutting-edge results in the healthcare domain. However, the framework can be tweaked to provide causality detection in other domains, as well. Significance: The presented framework is generic enough to be utilized in any domain, healthcare services can gain massive benefits due to the voluminous and various nature of its data. This causal knowledge extraction framework can be used to summarize clinical text, create personas, discover medical knowledge, and provide evidence to clinical decision making.

Muhammad Afzal, S. M. Riazul Islam, Maqbool Hussain et al.

Precision Medicine (PM) is an emerging approach that appears with the impression of changing the existing paradigm of medical practice. Recent advances in technological innovations and genetics, and the growing availability of health data have set a new pace of the research and imposes a set of new requirements on different stakeholders. To date, some studies are available that discuss about different aspects of PM. Nevertheless, a holistic representation of those aspects deemed to confer the technological perspective, in relation to applications and challenges, is mostly ignored. In this context, this paper surveys advances in PM from informatics viewpoint and reviews the enabling tools and techniques in a categorized manner. In addition, the study discusses how other technological paradigms including big data, artificial intelligence, and internet of things can be exploited to advance the potentials of PM. Furthermore, the paper provides some guidelines for future research for seamless implementation and wide-scale deployment of PM based on identified open issues and associated challenges. To this end, the paper proposes an integrated holistic framework for PM motivating informatics researchers to design their relevant research works in an appropriate context.