Heng-Da Cheng

Changfa Shi, Min Xian, Xiancheng Zhou et al.

Liver segmentation from abdominal CT images is an essential step for liver cancer computer-aided diagnosis and surgical planning. However, both the accuracy and robustness of existing liver segmentation methods cannot meet the requirements of clinical applications. In particular, for the common clinical cases where the liver tissue contains major pathology, current segmentation methods show poor performance. In this paper, we propose a novel low-rank tensor decomposition (LRTD) based multi-atlas segmentation (MAS) framework that achieves accurate and robust pathological liver segmentation of CT images. Firstly, we propose a multi-slice LRTD scheme to recover the underlying low-rank structure embedded in 3D medical images. It performs the LRTD on small image segments consisting of multiple consecutive image slices. Then, we present an LRTD-based atlas construction method to generate tumor-free liver atlases that mitigates the performance degradation of liver segmentation due to the presence of tumors. Finally, we introduce an LRTD-based MAS algorithm to derive patient-specific liver atlases for each test image, and to achieve accurate pairwise image registration and label propagation. Extensive experiments on three public databases of pathological liver cases validate the effectiveness of the proposed method. Both qualitative and quantitative results demonstrate that, in the presence of major pathology, the proposed method is more accurate and robust than state-of-the-art methods.

Kaige Zhang, Yingtao Zhang, Heng-Da Cheng

Fully convolutional network is a powerful tool for per-pixel semantic segmentation/detection. However, it is problematic when coping with crack detection using partially accurate ground truths (GTs): the network may easily converge to the status that treats all the pixels as background (BG) and still achieves a very good loss, named "All Black" phenomenon, due to the unavailability of accurate GTs and the data imbalance. To tackle this problem, we propose crack-patch-only (CPO) supervised generative adversarial learning for end-to-end training, which forces the network to always produce crack-GT images while reserves both crack and BG-image translation abilities by feeding a larger-size crack image into an asymmetric U-shape generator to overcome the "All Black" issue. The proposed approach is validated using four crack datasets; and achieves state-of-the-art performance comparing with that of the recently published works in efficiency and accuracy.

Kuan Huang, Yingtao Zhang, H. D. Cheng et al.

Breast cancer is one of the most serious disease affecting women's health. Due to low cost, portable, no radiation, and high efficiency, breast ultrasound (BUS) imaging is the most popular approach for diagnosing early breast cancer. However, ultrasound images are low resolution and poor quality. Thus, developing accurate detection system is a challenging task. In this paper, we propose a fully automatic segmentation algorithm consisting of two parts: fuzzy fully convolutional network and accurately fine-tuning post-processing based on breast anatomy constraints. In the first part, the image is preprocessed by contrast enhancement, and wavelet features are employed for image augmentation. A fuzzy membership function transforms the augmented BUS images into fuzzy domain. The features from convolutional layers are processed using fuzzy logic as well. The conditional random fields (CRFs) post-process the segmentation result. The location relation among the breast anatomy layers is utilized to improve the performance. The proposed method is applied to the dataset with 325 BUS images, and achieves state-of-art performance compared with that of existing methods with true positive rate 90.33%, false positive rate 9.00%, and intersection over union (IoU) 81.29% on tumor category, and overall intersection over union (mIoU) 80.47% over five categories: fat layer, mammary layer, muscle layer, background, and tumor.

Fei Xu, Min Xian, Yingtao Zhang et al.

Automatic tumor segmentation of breast ultrasound (BUS) image is quite challenging due to the complicated anatomic structure of breast and poor image quality. Most tumor segmentation approaches achieve good performance on BUS images collected in controlled settings; however, the performance degrades greatly with BUS images from different sources. Tumor saliency estimation (TSE) has attracted increasing attention to solving the problem by modeling radiologists' attention mechanism. In this paper, we propose a novel hybrid framework for TSE, which integrates both high-level domain-knowledge and robust low-level saliency assumptions and can overcome drawbacks caused by direct mapping in traditional TSE approaches. The new framework integrated the Neutro-Connectedness (NC) map, the adaptive-center, the correlation and the layer structure-based weighted map. The experimental results demonstrate that the proposed approach outperforms state-of-the-art TSE methods.

Hongjiao Guan, Yingtao Zhang, H. D. Cheng et al.

Abstaining classificaiton aims to reject to classify the easily misclassified examples, so it is an effective approach to increase the clasificaiton reliability and reduce the misclassification risk in the cost-sensitive applications. In such applications, different types of errors (false positive or false negative) usaully have unequal costs. And the error costs, which depend on specific applications, are usually unknown. However, current abstaining classification methods either do not distinguish the error types, or they need the cost information of misclassification and rejection, which are realized in the framework of cost-sensitive learning. In this paper, we propose a bounded-abstention method with two constraints of reject rates (BA2), which performs abstaining classification when error costs are unequal and unknown. BA2 aims to obtain the optimal area under the ROC curve (AUC) by constraining the reject rates of the positive and negative classes respectively. Specifically, we construct the receiver operating characteristic (ROC) curve, and stepwise search the optimal reject thresholds from both ends of the curve, untill the two constraints are satisfied. Experimental results show that BA2 obtains higher AUC and lower total cost than the state-of-the-art abstaining classification methods. Meanwhile, BA2 achieves controllable reject rates of the positive and negative classes.

Boyu Zhang, Yingtao Zhang, H. D. Cheng et al.

Osteoarthritis (OA) is one of the major health issues among the elderly population. MRI is the most popular technology to observe and evaluate the progress of OA course. However, the extreme labor cost of MRI analysis makes the process inefficient and expensive. Also, due to human error and subjective nature, the inter- and intra-observer variability is rather high. Computer-aided knee MRI segmentation is currently an active research field because it can alleviate doctors and radiologists from the time consuming and tedious job, and improve the diagnosis performance which has immense potential for both clinic and scientific research. In the past decades, researchers have investigated automatic/semi-automatic knee MRI segmentation methods extensively. However, to the best of our knowledge, there is no comprehensive survey paper in this field yet. In this survey paper, we classify the existing methods by their principles and discuss the current research status and point out the future research trend in-depth.

Min Xian, Yingtao Zhang, H. D. Cheng et al.

Breast cancer is one of the leading causes of cancer death among women worldwide. In clinical routine, automatic breast ultrasound (BUS) image segmentation is very challenging and essential for cancer diagnosis and treatment planning. Many BUS segmentation approaches have been studied in the last two decades, and have been proved to be effective on private datasets. Currently, the advancement of BUS image segmentation seems to meet its bottleneck. The improvement of the performance is increasingly challenging, and only few new approaches were published in the last several years. It is the time to look at the field by reviewing previous approaches comprehensively and to investigate the future directions. In this paper, we study the basic ideas, theories, pros and cons of the approaches, group them into categories, and extensively review each category in depth by discussing the principles, application issues, and advantages/disadvantages.

Jianrui Ding, Min Xian, H. D. Cheng et al.

Transesophageal echocardiography (TEE) is widely used to detect left atrium (LA)/left atrial appendage (LAA) thrombi. In this paper, the local binary pattern variance (LBPV) features are extracted from region of interest (ROI). And the dynamic features are formed by using the information of its neighbor frames in the sequence. The sequence is viewed as a bag, and the images in the sequence are considered as the instances. Multiple-instance learning (MIL) method is employed to solve the LAA thrombi detection. The experimental results show that the proposed method can achieve better performance than that by using other methods.