Ying Ding

Awais Naeem, Tianhao Li, Huang-Ru Liao et al.

Accurate diagnosis and prognosis assisted by pathology images are essential for cancer treatment selection and planning. Despite the recent trend of adopting deep-learning approaches for analyzing complex pathology images, they fall short as they often overlook the domain-expert understanding of tissue structure and cell composition. In this work, we focus on a challenging Open-ended Pathology VQA (PathVQA-Open) task and propose a novel framework named Path-RAG, which leverages HistoCartography to retrieve relevant domain knowledge from pathology images and significantly improves performance on PathVQA-Open. Admitting the complexity of pathology image analysis, Path-RAG adopts a human-centered AI approach by retrieving domain knowledge using HistoCartography to select the relevant patches from pathology images. Our experiments suggest that domain guidance can significantly boost the accuracy of LLaVA-Med from 38% to 47%, with a notable gain of 28% for H&E-stained pathology images in the PathVQA-Open dataset. For longer-form question and answer pairs, our model consistently achieves significant improvements of 32.5% in ARCH-Open PubMed and 30.6% in ARCH-Open Books on H\&E images. Our code and dataset is available here (https://github.com/embedded-robotics/path-rag).

Jian Yu, Joakim Nguyen, Jinrui Fang et al.

Accurate classification of pediatric central nervous system tumors remains challenging due to histological complexity and limited training data. While pathology foundation models have advanced whole-slide image (WSI) analysis, they often fail to leverage the rich, complementary information found in clinical text and tissue microarchitecture. To this end, we propose PathMoE, an interpretable multimodal framework that integrates H\&E slides, pathology reports, and nuclei-level cell graphs via an interaction-aware mixture-of-experts architecture built on state-of-the-art foundation models for each modality. By training specialized experts to capture modality uniqueness, redundancy, and synergy, PathMoE employs an input-dependent gating mechanism that dynamically weights these interactions, providing sample-level interpretability. We evaluate our framework on two dataset-specific classification tasks on an internal pediatric brain tumor dataset (PBT) and external TCGA datasets. PathMoE improves macro-F1 from 0.762 to 0.799 (+0.037) on PBT when integrating WSI, text, and graph modalities; on TCGA, augmenting WSI with graph knowledge improves macro-F1 from 0.668 to 0.709 (+0.041). These results demonstrate significant performance gains over state-of-the-art image-only baselines while revealing the specific modality interactions driving individual predictions. This interpretability is particularly critical for rare tumor subtypes, where transparent model reasoning is essential for clinical trust and diagnostic validation.

Ajay Kumar Jaiswal, Haoyu Ma, Tianlong Chen et al.

Lottery Ticket Hypothesis (LTH) suggests that a dense neural network contains a sparse sub-network that can match the performance of the original dense network when trained in isolation from scratch. Most works retrain the sparse sub-network with the same training protocols as its dense network, such as initialization, architecture blocks, and training recipes. However, till now it is unclear that whether these training protocols are optimal for sparse networks. In this paper, we demonstrate that it is unnecessary for spare retraining to strictly inherit those properties from the dense network. Instead, by plugging in purposeful "tweaks" of the sparse subnetwork architecture or its training recipe, its retraining can be significantly improved than the default, especially at high sparsity levels. Combining all our proposed "tweaks" can yield the new state-of-the-art performance of LTH, and these modifications can be easily adapted to other sparse training algorithms in general. Specifically, we have achieved a significant and consistent performance gain of1.05% - 4.93% for ResNet18 on CIFAR-100 over vanilla-LTH. Moreover, our methods are shown to generalize across datasets (CIFAR10, CIFAR100, TinyImageNet) and architectures (Vgg16, ResNet-18/ResNet-34, MobileNet). All codes will be publicly available.