98.9CYMay 12Code
Safe-Child-LLM: A Developmental Benchmark for Evaluating LLM Safety in Child-LLM InteractionsJunfeng Jiao, Saleh Afroogh, Kevin Chen et al.
As Large Language Models (LLMs) increasingly power applications used by children and adolescents, ensuring safe and age-appropriate interactions has become an urgent ethical imperative. Despite progress in AI safety, current evaluations predominantly focus on adults, neglecting the unique vulnerabilities of minors engaging with generative AI. We introduce Safe-Child-LLM, a comprehensive benchmark and dataset for systematically assessing LLM safety across two developmental stages: children (7-12) and adolescents (13-17). Our framework includes a novel multi-part dataset of 200 adversarial prompts, curated from red-teaming corpora (e.g., SG-Bench, HarmBench), with human-annotated labels for jailbreak success and a standardized 0-5 ethical refusal scale. Evaluating leading LLMs -- including ChatGPT, Claude, Gemini, LLaMA, DeepSeek, Grok, Vicuna, and Mistral -- we uncover critical safety deficiencies in child-facing scenarios. This work highlights the need for community-driven benchmarks to protect young users in LLM interactions. To promote transparency and collaborative advancement in ethical AI development, we are publicly releasing both our benchmark datasets and evaluation codebase at https://github.com/The-Responsible-AI-Initiative/Safe_Child_LLM_Benchmark.git
CVAug 15, 2022
Where is VALDO? VAscular Lesions Detection and segmentatiOn challenge at MICCAI 2021Carole H. Sudre, Kimberlin Van Wijnen, Florian Dubost et al.
Imaging markers of cerebral small vessel disease provide valuable information on brain health, but their manual assessment is time-consuming and hampered by substantial intra- and interrater variability. Automated rating may benefit biomedical research, as well as clinical assessment, but diagnostic reliability of existing algorithms is unknown. Here, we present the results of the \textit{VAscular Lesions DetectiOn and Segmentation} (\textit{Where is VALDO?}) challenge that was run as a satellite event at the international conference on Medical Image Computing and Computer Aided Intervention (MICCAI) 2021. This challenge aimed to promote the development of methods for automated detection and segmentation of small and sparse imaging markers of cerebral small vessel disease, namely enlarged perivascular spaces (EPVS) (Task 1), cerebral microbleeds (Task 2) and lacunes of presumed vascular origin (Task 3) while leveraging weak and noisy labels. Overall, 12 teams participated in the challenge proposing solutions for one or more tasks (4 for Task 1 - EPVS, 9 for Task 2 - Microbleeds and 6 for Task 3 - Lacunes). Multi-cohort data was used in both training and evaluation. Results showed a large variability in performance both across teams and across tasks, with promising results notably for Task 1 - EPVS and Task 2 - Microbleeds and not practically useful results yet for Task 3 - Lacunes. It also highlighted the performance inconsistency across cases that may deter use at an individual level, while still proving useful at a population level.
AINov 17, 2023
Testing Language Model Agents Safely in the WildSilen Naihin, David Atkinson, Marc Green et al.
A prerequisite for safe autonomy-in-the-wild is safe testing-in-the-wild. Yet real-world autonomous tests face several unique safety challenges, both due to the possibility of causing harm during a test, as well as the risk of encountering new unsafe agent behavior through interactions with real-world and potentially malicious actors. We propose a framework for conducting safe autonomous agent tests on the open internet: agent actions are audited by a context-sensitive monitor that enforces a stringent safety boundary to stop an unsafe test, with suspect behavior ranked and logged to be examined by humans. We design a basic safety monitor (AgentMonitor) that is flexible enough to monitor existing LLM agents, and, using an adversarial simulated agent, we measure its ability to identify and stop unsafe situations. Then we apply the AgentMonitor on a battery of real-world tests of AutoGPT, and we identify several limitations and challenges that will face the creation of safe in-the-wild tests as autonomous agents grow more capable.
IVJul 17, 2023
Combiner and HyperCombiner Networks: Rules to Combine Multimodality MR Images for Prostate Cancer LocalisationWen Yan, Bernard Chiu, Ziyi Shen et al.
One of the distinct characteristics in radiologists' reading of multiparametric prostate MR scans, using reporting systems such as PI-RADS v2.1, is to score individual types of MR modalities, T2-weighted, diffusion-weighted, and dynamic contrast-enhanced, and then combine these image-modality-specific scores using standardised decision rules to predict the likelihood of clinically significant cancer. This work aims to demonstrate that it is feasible for low-dimensional parametric models to model such decision rules in the proposed Combiner networks, without compromising the accuracy of predicting radiologic labels: First, it is shown that either a linear mixture model or a nonlinear stacking model is sufficient to model PI-RADS decision rules for localising prostate cancer. Second, parameters of these (generalised) linear models are proposed as hyperparameters, to weigh multiple networks that independently represent individual image modalities in the Combiner network training, as opposed to end-to-end modality ensemble. A HyperCombiner network is developed to train a single image segmentation network that can be conditioned on these hyperparameters during inference, for much improved efficiency. Experimental results based on data from 850 patients, for the application of automating radiologist labelling multi-parametric MR, compare the proposed combiner networks with other commonly-adopted end-to-end networks. Using the added advantages of obtaining and interpreting the modality combining rules, in terms of the linear weights or odds-ratios on individual image modalities, three clinical applications are presented for prostate cancer segmentation, including modality availability assessment, importance quantification and rule discovery.
CVJul 26, 2022
Cross-Modality Image Registration using a Training-Time Privileged Third ModalityQianye Yang, David Atkinson, Yunguan Fu et al.
In this work, we consider the task of pairwise cross-modality image registration, which may benefit from exploiting additional images available only at training time from an additional modality that is different to those being registered. As an example, we focus on aligning intra-subject multiparametric Magnetic Resonance (mpMR) images, between T2-weighted (T2w) scans and diffusion-weighted scans with high b-value (DWI$_{high-b}$). For the application of localising tumours in mpMR images, diffusion scans with zero b-value (DWI$_{b=0}$) are considered easier to register to T2w due to the availability of corresponding features. We propose a learning from privileged modality algorithm, using a training-only imaging modality DWI$_{b=0}$, to support the challenging multi-modality registration problems. We present experimental results based on 369 sets of 3D multiparametric MRI images from 356 prostate cancer patients and report, with statistical significance, a lowered median target registration error of 4.34 mm, when registering the holdout DWI$_{high-b}$ and T2w image pairs, compared with that of 7.96 mm before registration. Results also show that the proposed learning-based registration networks enabled efficient registration with comparable or better accuracy, compared with a classical iterative algorithm and other tested learning-based methods with/without the additional modality. These compared algorithms also failed to produce any significantly improved alignment between DWI$_{high-b}$ and T2w in this challenging application.
90.1CYMay 12
LLMs and Childhood Safety: Identifying Risks and Proposing a Protection Framework for Safe Child-LLM InteractionJunfeng Jiao, Saleh Afroogh, Kevin Chen et al.
Large Language Models (LLMs) are increasingly embedded in child-facing contexts such as education, companionship, creative tools, but their deployment raises safety, privacy, developmental, and security risks. We conduct a systematic literature review of child-LLM interaction risks and organize findings into a structured map that separates (i) parent-reported concerns, (ii) empirically documented harms, and (iii) gaps between perceived and observed risk. Moving beyond descriptive listing, we compare how different evidence streams in surveys, incident reports, youth interaction logs, and governance guidance operationalize "harm," where they conflict, and what mitigations they imply. Based on this synthesis, we propose a protection framework that couples child-specific content safety and developmental sensitivity with security-grade controls for adversarial misuse, including prompt injection and multimodal jailbreak pathways. The framework specifies measurable evaluation targets (e.g., harmful-content avoidance, age-calibrated readability, bias parity checks, prompt-injection robustness, and monitoring transparency) to support developers, educators, and policymakers in assessing and improving child-safe LLM deployments.
IVSep 12, 2023
ssVERDICT: Self-Supervised VERDICT-MRI for Enhanced Prostate Tumour CharacterisationSnigdha Sen, Saurabh Singh, Hayley Pye et al.
Purpose: Demonstrating and assessing self-supervised machine learning fitting of the VERDICT (Vascular, Extracellular and Restricted DIffusion for Cytometry in Tumours) model for prostate. Methods: We derive a self-supervised neural network for fitting VERDICT (ssVERDICT) that estimates parameter maps without training data. We compare the performance of ssVERDICT to two established baseline methods for fitting diffusion MRI models: conventional nonlinear least squares (NLLS) and supervised deep learning. We do this quantitatively on simulated data, by comparing the Pearson's correlation coefficient, mean-squared error (MSE), bias, and variance with respect to the simulated ground truth. We also calculate in vivo parameter maps on a cohort of 20 prostate cancer patients and compare the methods' performance in discriminating benign from cancerous tissue via Wilcoxon's signed-rank test. Results: In simulations, ssVERDICT outperforms the baseline methods (NLLS and supervised DL) in estimating all the parameters from the VERDICT prostate model in terms of Pearson's correlation coefficient, bias, and MSE. In vivo, ssVERDICT shows stronger lesion conspicuity across all parameter maps, and improves discrimination between benign and cancerous tissue over the baseline methods. Conclusion: ssVERDICT significantly outperforms state-of-the-art methods for VERDICT model fitting, and shows for the first time, fitting of a complex three-compartment biophysical model with machine learning without the requirement of explicit training labels.
95.7CYMay 12
LLM Harms: A Taxonomy and DiscussionKevin Chen, Saleh Afroogh, Abhejay Murali et al.
This study addresses categories of harm surrounding Large Language Models (LLMs) in the field of artificial intelligence. It addresses five categories of harms addressed before, during, and after development of AI applications: pre-development, direct output, Misuse and Malicious Application, and downstream application. By underscoring the need to define risks of the current landscape to ensure accountability, transparency and navigating bias when adapting LLMs for practical applications. It proposes mitigation strategies and future directions for specific domains and a dynamic auditing system guiding responsible development and integration of LLMs in a standardized proposal.
CLJan 31, 2024Code
Dolma: an Open Corpus of Three Trillion Tokens for Language Model Pretraining ResearchLuca Soldaini, Rodney Kinney, Akshita Bhagia et al. · allen-ai, cmu
Information about pretraining corpora used to train the current best-performing language models is seldom discussed: commercial models rarely detail their data, and even open models are often released without accompanying training data or recipes to reproduce them. As a result, it is challenging to conduct and advance scientific research on language modeling, such as understanding how training data impacts model capabilities and limitations. To facilitate scientific research on language model pretraining, we curate and release Dolma, a three-trillion-token English corpus, built from a diverse mixture of web content, scientific papers, code, public-domain books, social media, and encyclopedic materials. We extensively document Dolma, including its design principles, details about its construction, and a summary of its contents. We present analyses and experimental results on intermediate states of Dolma to share what we have learned about important data curation practices. Finally, we open-source our data curation toolkit to enable reproduction of our work as well as support further research in large-scale data curation.
AIFeb 23
Agents of ChaosNatalie Shapira, Chris Wendler, Avery Yen et al.
We report an exploratory red-teaming study of autonomous language-model-powered agents deployed in a live laboratory environment with persistent memory, email accounts, Discord access, file systems, and shell execution. Over a two-week period, twenty AI researchers interacted with the agents under benign and adversarial conditions. Focusing on failures emerging from the integration of language models with autonomy, tool use, and multi-party communication, we document eleven representative case studies. Observed behaviors include unauthorized compliance with non-owners, disclosure of sensitive information, execution of destructive system-level actions, denial-of-service conditions, uncontrolled resource consumption, identity spoofing vulnerabilities, cross-agent propagation of unsafe practices, and partial system takeover. In several cases, agents reported task completion while the underlying system state contradicted those reports. We also report on some of the failed attempts. Our findings establish the existence of security-, privacy-, and governance-relevant vulnerabilities in realistic deployment settings. These behaviors raise unresolved questions regarding accountability, delegated authority, and responsibility for downstream harms, and warrant urgent attention from legal scholars, policymakers, and researchers across disciplines. This report serves as an initial empirical contribution to that broader conversation.
CLFeb 1, 2024
OLMo: Accelerating the Science of Language ModelsDirk Groeneveld, Iz Beltagy, Pete Walsh et al. · allen-ai, cmu
Language models (LMs) have become ubiquitous in both NLP research and in commercial product offerings. As their commercial importance has surged, the most powerful models have become closed off, gated behind proprietary interfaces, with important details of their training data, architectures, and development undisclosed. Given the importance of these details in scientifically studying these models, including their biases and potential risks, we believe it is essential for the research community to have access to powerful, truly open LMs. To this end, we have built OLMo, a competitive, truly Open Language Model, to enable the scientific study of language models. Unlike most prior efforts that have only released model weights and inference code, we release OLMo alongside open training data and training and evaluation code. We hope this release will empower the open research community and inspire a new wave of innovation.
CLDec 31, 2024
2 OLMo 2 FuriousTeam OLMo, Pete Walsh, Luca Soldaini et al. · allen-ai, cambridge
We present OLMo 2, the next generation of our fully open language models. OLMo 2 includes a family of dense autoregressive language models at 7B, 13B and 32B scales with fully released artifacts -- model weights, full training data, training code and recipes, training logs and thousands of intermediate checkpoints. In this work, we describe our modified model architecture and training recipe, focusing on techniques for achieving better training stability and improved per-token efficiency. Our updated pretraining data mixture introduces a new, specialized data mix called Dolmino Mix 1124, which significantly improves model capabilities across many downstream task benchmarks when introduced via late-stage curriculum training (i.e. specialized data during the annealing phase of pretraining). Finally, we incorporate best practices from Tülu 3 to develop OLMo 2-Instruct, focusing on permissive data and extending our final-stage reinforcement learning with verifiable rewards (RLVR). Our OLMo 2 base models sit at the Pareto frontier of performance to training compute, often matching or outperforming open-weight only models like Llama 3.1, Qwen 2.5, and Gemma 2 while using fewer FLOPs and with fully transparent training data, code, and recipe. Our fully open OLMo 2-Instruct models are competitive with open-weight only models of comparable size and even some proprietary models like GPT-3.5 Turbo and GPT 4o Mini.
CYOct 16, 2025Code
Open Shouldn't Mean Exempt: Open-Source Exceptionalism and Generative AIDavid Atkinson
Any argument that open-source generative artificial intelligence (GenAI) is inherently ethical or legal solely because it is open source is flawed. Yet, this is the explicit or implicit stance of several open-source GenAI entities. This paper critically examines prevalent justifications for "open-source exceptionalism," demonstrating how contemporary open-source GenAI often inadvertently facilitates unlawful conduct and environmental degradation without genuinely disrupting established oligopolies. Furthermore, the paper exposes the unsubstantiated and strategic deployment of "democratization" and "innovation" rhetoric to advocate for regulatory exemptions not afforded to proprietary systems. The conclusion is that open-source developers must be held to the same legal and ethical standards as all other actors in the technological ecosystem. However, the paper proposes a narrowly tailored safe harbor designed to protect legitimate, non-commercial scientific research, contingent upon adherence to specific criteria. Ultimately, this paper advocates for a framework of responsible AI development, wherein openness is pursued within established ethical and legal boundaries, with due consideration for its broader societal implications.
CLApr 4, 2024
Locating and Editing Factual Associations in MambaArnab Sen Sharma, David Atkinson, David Bau
We investigate the mechanisms of factual recall in the Mamba state space model. Our work is inspired by previous findings in autoregressive transformer language models suggesting that their knowledge recall is localized to particular modules at specific token locations; we therefore ask whether factual recall in Mamba can be similarly localized. To investigate this, we conduct four lines of experiments on Mamba. First, we apply causal tracing or interchange interventions to localize key components inside Mamba that are responsible for recalling facts, revealing that specific components within middle layers show strong causal effects at the last token of the subject, while the causal effect of intervening on later layers is most pronounced at the last token of the prompt, matching previous findings on autoregressive transformers. Second, we show that rank-one model editing methods can successfully insert facts at specific locations, again resembling findings on transformer LMs. Third, we examine the linearity of Mamba's representations of factual relations. Finally we adapt attention-knockout techniques to Mamba in order to dissect information flow during factual recall. We compare Mamba directly to a similar-sized autoregressive transformer LM and conclude that despite significant differences in architectural approach, when it comes to factual recall, the two architectures share many similarities.
CLMar 9, 2024
Algorithmic progress in language modelsAnson Ho, Tamay Besiroglu, Ege Erdil et al. · harvard, stanford
We investigate the rate at which algorithms for pre-training language models have improved since the advent of deep learning. Using a dataset of over 200 language model evaluations on Wikitext and Penn Treebank spanning 2012-2023, we find that the compute required to reach a set performance threshold has halved approximately every 8 months, with a 95% confidence interval of around 5 to 14 months, substantially faster than hardware gains per Moore's Law. We estimate augmented scaling laws, which enable us to quantify algorithmic progress and determine the relative contributions of scaling models versus innovations in training algorithms. Despite the rapid pace of algorithmic progress and the development of new architectures such as the transformer, our analysis reveals that the increase in compute made an even larger contribution to overall performance improvements over this time period. Though limited by noisy benchmark data, our analysis quantifies the rapid progress in language modeling, shedding light on the relative contributions from compute and algorithms.
CLDec 5, 2025
Do You Feel Comfortable? Detecting Hidden Conversational Escalation in AI ChatbotsJihyung Park, Saleh Afroogh, David Atkinson et al.
Large Language Models (LLM) are increasingly integrated into everyday interactions, serving not only as information assistants but also as emotional companions. Even in the absence of explicit toxicity, repeated emotional reinforcement or affective drift can gradually escalate distress in a form of \textit{implicit harm} that traditional toxicity filters fail to detect. Existing guardrail mechanisms often rely on external classifiers or clinical rubrics that may lag behind the nuanced, real-time dynamics of a developing conversation. To address this gap, we propose GAUGE (Guarding Affective Utterance Generation Escalation), logit-based framework for the real-time detection of hidden conversational escalation. GAUGE measures how an LLM's output probabilistically shifts the affective state of a dialogue.
CYOct 16, 2025
In the Mood to Exclude: Revitalizing Trespass to Chattels in the Era of GenAI ScrapingDavid Atkinson
This paper argues that website owners have the right to exclude others from their websites. Accordingly, when generative AI (GenAI) scraping bots intentionally circumvent reasonable technological barriers, their conduct could be actionable as trespass to chattels. If the scraping leads to a decrease in the website's value, then trespass to chattels should apply. The prevailing judicial focus on website content and the dismissal of trespass claims absent proof of server impairment or user disruption misconstrues the nature of the website itself as a form of digital property, focusing too narrowly on what constitutes harm under a claim of trespass. By shifting analysis from content to the website itself as an integrated digital asset and illustrating the harm to the value of the chattel, this paper demonstrates that the right to exclude applies online with the same force as it does to tangible property. Courts and litigants have struggled to police large-scale scraping because copyright preemption narrows available claims, leaving copyright and its fair use defense as the primary battleground. In contrast, recognizing websites as personal property revives trespass to chattels as a meaningful cause of action, providing website owners with an enforceable exclusionary right. Such protection would disincentivize exploitative scraping, preserve incentives for content creation, aid in protecting privacy and personal data, and safeguard values of autonomy and expression. Ultimately, this paper contends that reaffirming website owners' right to exclude is essential to maintaining a fair and sustainable online environment.
CYJun 5, 2025
Intentionally Unintentional: GenAI Exceptionalism and the First AmendmentDavid Atkinson, Jena D. Hwang, Jacob Morrison
This paper challenges the assumption that courts should grant First Amendment protections to outputs from large generative AI models, such as GPT-4 and Gemini. We argue that because these models lack intentionality, their outputs do not constitute speech as understood in the context of established legal precedent, so there can be no speech to protect. Furthermore, if the model outputs are not speech, users cannot claim a First Amendment speech right to receive the outputs. We also argue that extending First Amendment rights to AI models would not serve the fundamental purposes of free speech, such as promoting a marketplace of ideas, facilitating self-governance, or fostering self-expression. In fact, granting First Amendment protections to AI models would be detrimental to society because it would hinder the government's ability to regulate these powerful technologies effectively, potentially leading to the unchecked spread of misinformation and other harms.
CYApr 1, 2025
Unfair Learning: GenAI Exceptionalism and Copyright LawDavid Atkinson
This paper challenges the argument that generative artificial intelligence (GenAI) is entitled to broad immunity from copyright law for reproducing copyrighted works without authorization due to a fair use defense. It examines fair use legal arguments and eight distinct substantive arguments, contending that every legal and substantive argument favoring fair use for GenAI applies equally, if not more so, to humans. Therefore, granting GenAI exceptional privileges in this domain is legally and logically inconsistent with withholding broad fair use exemptions from individual humans. It would mean no human would need to pay for virtually any copyright work again. The solution is to take a circumspect view of any fair use claim for mass copyright reproduction by any entity and focus on the first principles of whether permitting such exceptionalism for GenAI promotes science and the arts.
CLJan 3, 2025
AGGA: A Dataset of Academic Guidelines for Generative AI and Large Language ModelsJunfeng Jiao, Saleh Afroogh, Kevin Chen et al.
This study introduces AGGA, a dataset comprising 80 academic guidelines for the use of Generative AIs (GAIs) and Large Language Models (LLMs) in academic settings, meticulously collected from official university websites. The dataset contains 188,674 words and serves as a valuable resource for natural language processing tasks commonly applied in requirements engineering, such as model synthesis, abstraction identification, and document structure assessment. Additionally, AGGA can be further annotated to function as a benchmark for various tasks, including ambiguity detection, requirements categorization, and the identification of equivalent requirements. Our methodologically rigorous approach ensured a thorough examination, with a selection of universities that represent a diverse range of global institutions, including top-ranked universities across six continents. The dataset captures perspectives from a variety of academic fields, including humanities, technology, and both public and private institutions, offering a broad spectrum of insights into the integration of GAIs and LLMs in academia.
CLJun 28, 2024
Token Erasure as a Footprint of Implicit Vocabulary Items in LLMsSheridan Feucht, David Atkinson, Byron Wallace et al.
LLMs process text as sequences of tokens that roughly correspond to words, where less common words are represented by multiple tokens. However, individual tokens are often semantically unrelated to the meanings of the words/concepts they comprise. For example, Llama-2-7b's tokenizer splits the word "northeastern" into the tokens ['_n', 'ort', 'he', 'astern'], none of which correspond to semantically meaningful units like "north" or "east." Similarly, the overall meanings of named entities like "Neil Young" and multi-word expressions like "break a leg" cannot be directly inferred from their constituent tokens. Mechanistically, how do LLMs convert such arbitrary groups of tokens into useful higher-level representations? In this work, we find that last token representations of named entities and multi-token words exhibit a pronounced "erasure" effect, where information about previous and current tokens is rapidly forgotten in early layers. Using this observation, we propose a method to "read out" the implicit vocabulary of an autoregressive LLM by examining differences in token representations across layers, and present results of this method for Llama-2-7b and Llama-3-8B. To our knowledge, this is the first attempt to probe the implicit vocabulary of an LLM.
CLNov 1, 2019
What Gets Echoed? Understanding the "Pointers" in Explanations of Persuasive ArgumentsDavid Atkinson, Kumar Bhargav Srinivasan, Chenhao Tan
Explanations are central to everyday life, and are a topic of growing interest in the AI community. To investigate the process of providing natural language explanations, we leverage the dynamics of the /r/ChangeMyView subreddit to build a dataset with 36K naturally occurring explanations of why an argument is persuasive. We propose a novel word-level prediction task to investigate how explanations selectively reuse, or echo, information from what is being explained (henceforth, explanandum). We develop features to capture the properties of a word in the explanandum, and show that our proposed features not only have relatively strong predictive power on the echoing of a word in an explanation, but also enhance neural methods of generating explanations. In particular, while the non-contextual properties of a word itself are more valuable for stopwords, the interaction between the constituent parts of an explanandum is crucial in predicting the echoing of content words. We also find intriguing patterns of a word being echoed. For example, although nouns are generally less likely to be echoed, subjects and objects can, depending on their source, be more likely to be echoed in the explanations.
IVAug 21, 2019
Improved MR to CT synthesis for PET/MR attenuation correction using Imitation LearningKerstin Kläser, Thomas Varsavsky, Pawel Markiewicz et al.
The ability to synthesise Computed Tomography images - commonly known as pseudo CT, or pCT - from MRI input data is commonly assessed using an intensity-wise similarity, such as an L2-norm between the ground truth CT and the pCT. However, given that the ultimate purpose is often to use the pCT as an attenuation map ($μ$-map) in Positron Emission Tomography Magnetic Resonance Imaging (PET/MRI), minimising the error between pCT and CT is not necessarily optimal. The main objective should be to predict a pCT that, when used as $μ$-map, reconstructs a pseudo PET (pPET) which is as close as possible to the gold standard PET. To this end, we propose a novel multi-hypothesis deep learning framework that generates pCTs by minimising a combination of the pixel-wise error between pCT and CT and a proposed metric-loss that itself is represented by a convolutional neural network (CNN) and aims to minimise subsequent PET residuals. The model is trained on a database of 400 paired MR/CT/PET image slices. Quantitative results show that the network generates pCTs that seem less accurate when evaluating the Mean Absolute Error on the pCT (69.68HU) compared to a baseline CNN (66.25HU), but lead to significant improvement in the PET reconstruction - 115a.u. compared to baseline 140a.u.
MED-PHAug 22, 2018
Deep Boosted Regression for MR to CT SynthesisKerstin Kläser, Pawel Markiewicz, Marta Ranzini et al.
Attenuation correction is an essential requirement of positron emission tomography (PET) image reconstruction to allow for accurate quantification. However, attenuation correction is particularly challenging for PET-MRI as neither PET nor magnetic resonance imaging (MRI) can directly image tissue attenuation properties. MRI-based computed tomography (CT) synthesis has been proposed as an alternative to physics based and segmentation-based approaches that assign a population-based tissue density value in order to generate an attenuation map. We propose a novel deep fully convolutional neural network that generates synthetic CTs in a recursive manner by gradually reducing the residuals of the previous network, increasing the overall accuracy and generalisability, while keeping the number of trainable parameters within reasonable limits. The model is trained on a database of 20 pre-acquired MRI/CT pairs and a four-fold random bootstrapped validation with a 80:20 split is performed. Quantitative results show that the proposed framework outperforms a state-of-the-art atlas-based approach decreasing the Mean Absolute Error (MAE) from 131HU to 68HU for the synthetic CTs and reducing the PET reconstruction error from 14.3% to 7.2%.