Tianyu Wu

Mostafa Karimi, Changliang Liu, Kenichi Kumatani et al.

Self-supervised learning (SSL) methods have proven to be very successful in automatic speech recognition (ASR). These great improvements have been reported mostly based on highly curated datasets such as LibriSpeech for non-streaming End-to-End ASR models. However, the pivotal characteristics of SSL is to be utilized for any untranscribed audio data. In this paper, we provide a full exploration on how to utilize uncurated audio data in SSL from data pre-processing to deploying an streaming hybrid ASR model. More specifically, we present (1) the effect of Audio Event Detection (AED) model in data pre-processing pipeline (2) analysis on choosing optimizer and learning rate scheduling (3) comparison of recently developed contrastive losses, (4) comparison of various pre-training strategies such as utilization of in-domain versus out-domain pre-training data, monolingual versus multilingual pre-training data, multi-head multilingual SSL versus single-head multilingual SSL and supervised pre-training versus SSL. The experimental results show that SSL pre-training with in-domain uncurated data can achieve better performance in comparison to all the alternative out-domain pre-training strategies.

Tianyu Wu, Yang Tang, Qiyu Sun et al.

In recent years, artificial intelligence has played an important role on accelerating the whole process of drug discovery. Various of molecular representation schemes of different modals (e.g. textual sequence or graph) are developed. By digitally encoding them, different chemical information can be learned through corresponding network structures. Molecular graphs and Simplified Molecular Input Line Entry System (SMILES) are popular means for molecular representation learning in current. Previous works have done attempts by combining both of them to solve the problem of specific information loss in single-modal representation on various tasks. To further fusing such multi-modal imformation, the correspondence between learned chemical feature from different representation should be considered. To realize this, we propose a novel framework of molecular joint representation learning via Multi-Modal information of SMILES and molecular Graphs, called MMSG. We improve the self-attention mechanism by introducing bond level graph representation as attention bias in Transformer to reinforce feature correspondence between multi-modal information. We further propose a Bidirectional Message Communication Graph Neural Network (BMC GNN) to strengthen the information flow aggregated from graphs for further combination. Numerous experiments on public property prediction datasets have demonstrated the effectiveness of our model.

Tianyu Wu, Yang Tang

Antimicrobial resistance is one of the biggest health problem, especially in the current period of COVID-19 pandemic. Due to the unique membrane-destruction bactericidal mechanism, antimicrobial peptide-mimetic copolymers are paid more attention and it is urgent to find more potential candidates with broad-spectrum antibacterial efficacy and low toxicity. Artificial intelligence has shown significant performance on small molecule or biotech drugs, however, the higher-dimension of polymer space and the limited experimental data restrict the application of existing methods on copolymer design. Herein, we develop a universal random copolymer inverse design system via multi-model copolymer representation learning, knowledge distillation and reinforcement learning. Our system realize a high-precision antimicrobial activity prediction with few-shot data by extracting various chemical information from multi-modal copolymer representations. By pre-training a scaffold-decorator generative model via knowledge distillation, copolymer space are greatly contracted to the near space of existing data for exploration. Thus, our reinforcement learning algorithm can be adaptive for customized generation on specific scaffolds and requirements on property or structures. We apply our system on collected antimicrobial peptide-mimetic copolymers data, and we discover candidate copolymers with desired properties.

Tianyu Wu, Konrad Schindler, Cenek Albl

We investigate the possibility of 3D scene reconstruction from two or more overlapping webcam streams. A large, and growing, number of webcams observe places of interest and are publicly accessible. The question naturally arises: can we make use of this free data source for 3D computer vision? It turns out that the task to reconstruct scene structure from webcam streams is very different from standard structure-from-motion (SfM), and conventional SfM pipelines fail. In the webcam setting there are very few views of the same scene, in most cases only the minimum of two. These viewpoints often have large baselines and/or scale differences, their overlap is rather limited, and besides unknown internal and external calibration also their temporal synchronisation is unknown. On the other hand, they record rather large fields of view continuously over long time spans, so that they regularly observe dynamic objects moving through the scene. We show how to leverage recent advances in several areas of computer vision to adapt SfM reconstruction to this particular scenario and reconstruct the unknown camera poses, the 3D scene structure, and the 3D trajectories of dynamic objects.