4.1LGNov 14, 2025
Gene Incremental Learning for Single-Cell TranscriptomicsJiaxin Qi, Yan Cui, Jianqiang Huang et al.
Classes, as fundamental elements of Computer Vision, have been extensively studied within incremental learning frameworks. In contrast, tokens, which play essential roles in many research fields, exhibit similar characteristics of growth, yet investigations into their incremental learning remain significantly scarce. This research gap primarily stems from the holistic nature of tokens in language, which imposes significant challenges on the design of incremental learning frameworks for them. To overcome this obstacle, in this work, we turn to a type of token, gene, for a large-scale biological dataset--single-cell transcriptomics--to formulate a pipeline for gene incremental learning and establish corresponding evaluations. We found that the forgetting problem also exists in gene incremental learning, thus we adapted existing class incremental learning methods to mitigate the forgetting of genes. Through extensive experiments, we demonstrated the soundness of our framework design and evaluations, as well as the effectiveness of our method adaptations. Finally, we provide a complete benchmark for gene incremental learning in single-cell transcriptomics.
4.1LGJul 5, 2025
Graph Neural Networks as a Substitute for Transformers in Single-Cell TranscriptomicsJiaxin Qi, Yan Cui, Jinli Ou et al.
Graph Neural Networks (GNNs) and Transformers share significant similarities in their encoding strategies for interacting with features from nodes of interest, where Transformers use query-key scores and GNNs use edges. Compared to GNNs, which are unable to encode relative positions, Transformers leverage dynamic attention capabilities to better represent relative relationships, thereby becoming the standard backbones in large-scale sequential pre-training. However, the subtle difference prompts us to consider: if positions are no longer crucial, could we substitute Transformers with Graph Neural Networks in some fields such as Single-Cell Transcriptomics? In this paper, we first explore the similarities and differences between GNNs and Transformers, specifically in terms of relative positions. Additionally, we design a synthetic example to illustrate their equivalence where there are no relative positions between tokens in the sample. Finally, we conduct extensive experiments on a large-scale position-agnostic dataset-single-cell transcriptomics-finding that GNNs achieve competitive performance compared to Transformers while consuming fewer computation resources. These findings provide novel insights for researchers in the field of single-cell transcriptomics, challenging the prevailing notion that the Transformer is always the optimum choice.
Exploring Linear Attention Alternative for Single Image Super-ResolutionRongchang Lu, Changyu Li, Donghang Li et al.
Deep learning-based single-image super-resolution (SISR) technology focuses on enhancing low-resolution (LR) images into high-resolution (HR) ones. Although significant progress has been made, challenges remain in computational complexity and quality, particularly in remote sensing image processing. To address these issues, we propose our Omni-Scale RWKV Super-Resolution (OmniRWKVSR) model which presents a novel approach that combines the Receptance Weighted Key Value (RWKV) architecture with feature extraction techniques such as Visual RWKV Spatial Mixing (VRSM) and Visual RWKV Channel Mixing (VRCM), aiming to overcome the limitations of existing methods and achieve superior SISR performance. This work has proved able to provide effective solutions for high-quality image reconstruction. Under the 4x Super-Resolution tasks, compared to the MambaIR model, we achieved an average improvement of 0.26% in PSNR and 0.16% in SSIM.
5.1IVDec 31, 2024
GDSR: Global-Detail Integration through Dual-Branch Network with Wavelet Losses for Remote Sensing Image Super-ResolutionQiwei Zhu, Kai Li, Guojing Zhang et al.
In recent years, deep neural networks, including Convolutional Neural Networks, Transformers, and State Space Models, have achieved significant progress in Remote Sensing Image (RSI) Super-Resolution (SR). However, existing SR methods typically overlook the complementary relationship between global and local dependencies. These methods either focus on capturing local information or prioritize global information, which results in models that are unable to effectively capture both global and local features simultaneously. Moreover, their computational cost becomes prohibitive when applied to large-scale RSIs. To address these challenges, we introduce the novel application of Receptance Weighted Key Value (RWKV) to RSI-SR, which captures long-range dependencies with linear complexity. To simultaneously model global and local features, we propose the Global-Detail dual-branch structure, GDSR, which performs SR by paralleling RWKV and convolutional operations to handle large-scale RSIs. Furthermore, we introduce the Global-Detail Reconstruction Module (GDRM) as an intermediary between the two branches to bridge their complementary roles. In addition, we propose the Dual-Group Multi-Scale Wavelet Loss, a wavelet-domain constraint mechanism via dual-group subband strategy and cross-resolution frequency alignment for enhanced reconstruction fidelity in RSI-SR. Extensive experiments under two degradation methods on several benchmarks, including AID, UCMerced, and RSSRD-QH, demonstrate that GSDR outperforms the state-of-the-art Transformer-based method HAT by an average of 0.09 dB in PSNR, while using only 63% of its parameters and 51% of its FLOPs, achieving an inference speed 3.2 times faster.