Bo Du

Qiang Huang, Jiawei Jiang, Xi Susie Rao et al. · eth-zurich

To handle graphs in which features or connectivities are evolving over time, a series of temporal graph neural networks (TGNNs) have been proposed. Despite the success of these TGNNs, the previous TGNN evaluations reveal several limitations regarding four critical issues: 1) inconsistent datasets, 2) inconsistent evaluation pipelines, 3) lacking workload diversity, and 4) lacking efficient comparison. Overall, there lacks an empirical study that puts TGNN models onto the same ground and compares them comprehensively. To this end, we propose BenchTemp, a general benchmark for evaluating TGNN models on various workloads. BenchTemp provides a set of benchmark datasets so that different TGNN models can be fairly compared. Further, BenchTemp engineers a standard pipeline that unifies the TGNN evaluation. With BenchTemp, we extensively compare the representative TGNN models on different tasks (e.g., link prediction and node classification) and settings (transductive and inductive), w.r.t. both effectiveness and efficiency metrics. We have made BenchTemp publicly available at https://github.com/qianghuangwhu/benchtemp.

Baoru Huang, Tuan Vo, Chayun Kongtongvattana et al.

Real-time visual feedback from catheterization analysis is crucial for enhancing surgical safety and efficiency during endovascular interventions. However, existing datasets are often limited to specific tasks, small scale, and lack the comprehensive annotations necessary for broader endovascular intervention understanding. To tackle these limitations, we introduce CathAction, a large-scale dataset for catheterization understanding. Our CathAction dataset encompasses approximately 500,000 annotated frames for catheterization action understanding and collision detection, and 25,000 ground truth masks for catheter and guidewire segmentation. For each task, we benchmark recent related works in the field. We further discuss the challenges of endovascular intentions compared to traditional computer vision tasks and point out open research questions. We hope that CathAction will facilitate the development of endovascular intervention understanding methods that can be applied to real-world applications. The dataset is available at https://airvlab.github.io/cathaction/.

Haoshen Wang, Lei Chen, Wei-Hua Zhang et al.

Cone beam computed tomography (CBCT)-guided puncture has become an established approach for diagnosing and treating early- to mid-stage thoracic tumours, yet the associated radiation exposure substantially elevates the risk of secondary malignancies. Although multiple low-dose CBCT strategies have been introduced, none have undergone validation using large-scale multicenter retrospective datasets, and prospective clinical evaluation remains lacking. Here, we propose DeepPriorCBCT - a three-stage deep learning framework that achieves diagnostic-grade reconstruction using only one-sixth of the conventional radiation dose. 4102 patients with 8675 CBCT scans from 12 centers were included to develop and validate DeepPriorCBCT. Additionally, a prospective cross-over trial (Registry number: NCT07035977) which recruited 138 patients scheduled for percutaneous thoracic puncture was conducted to assess the model's clinical applicability. Assessment by 11 physicians confirmed that reconstructed images were indistinguishable from original scans. Moreover, diagnostic performance and overall image quality were comparable to those generated by standard reconstruction algorithms. In the prospective trial, five radiologists reported no significant differences in image quality or lesion assessment between DeepPriorCBCT and the clinical standard (all P>0.05). Likewise, 25 interventionalists expressed no preference between model-based and full-sampling images for surgical guidance (Kappa<0.2). Radiation exposure with DeepPriorCBCT was reduced to approximately one-sixth of that with the conventional approach, and collectively, the findings confirm that it enables high-quality CBCT reconstruction under sparse sampling conditions while markedly decreasing intraoperative radiation risk.

Hongzhi Zhang, Xiuwen Gong, Shirui Pan et al.

Drug-target interaction (DTI) prediction is a critical component of the drug discovery process. In the drug development engineering field, predicting novel drug-target interactions is extremely crucial.However, although existing methods have achieved high accuracy levels in predicting known drugs and drug targets, they fail to utilize global protein information during DTI prediction. This leads to an inability to effectively predict interaction the interactions between novel drugs and their targets. As a result, the cross-field information fusion strategy is employed to acquire local and global protein information. Thus, we propose the siamese drug-target interaction SiamDTI prediction method, which utilizes a double channel network structure for cross-field supervised learning.Experimental results on three benchmark datasets demonstrate that SiamDTI achieves higher accuracy levels than other state-of-the-art (SOTA) methods on novel drugs and targets.Additionally, SiamDTI's performance with known drugs and targets is comparable to that of SOTA approachs. The code is available at https://anonymous.4open.science/r/DDDTI-434D.

Shuai Wang, Liang Ding, Li Shen et al.

Advancing automated programming necessitates robust and comprehensive code generation benchmarks, yet current evaluation frameworks largely neglect object-oriented programming (OOP) in favor of functional programming (FP), e.g., HumanEval and MBPP. To address this, our study introduces a pioneering OOP-focused benchmark, featuring 431 Python programs that encompass essential OOP concepts and features like classes and encapsulation methods. We propose a novel evaluation metric, pass@o, tailored for OOP, enhancing traditional pass@k measures. Our evaluation of 23 leading large language models (LLMs), including both general and code-specialized models, reveals three key insights: 1) pass@o offers a more relevant and comprehensive assessment for OOP code generation; 2) Despite excelling in FP, code-specialized LLMs like WizardCoder lag in OOP compared to models like ChatGPT; 3) The poor performance of all advanced LLMs on our OOP benchmark highlights a critical need for improvements in this field. Our benchmark and scripts are publicly released at: https://github.com/alphadl/OOP-eval.

Chuang Liu, Wenhang Yu, Kuang Gao et al.

Graph pooling has been increasingly recognized as crucial for Graph Neural Networks (GNNs) to facilitate hierarchical graph representation learning. Existing graph pooling methods commonly consist of two stages: selecting top-ranked nodes and discarding the remaining to construct coarsened graph representations. However, this paper highlights two key issues with these methods: 1) The process of selecting nodes to discard frequently employs additional Graph Convolutional Networks or Multilayer Perceptrons, lacking a thorough evaluation of each node's impact on the final graph representation and subsequent prediction tasks. 2) Current graph pooling methods tend to directly discard the noise segment (dropped) of the graph without accounting for the latent information contained within these elements. To address the first issue, we introduce a novel Graph Explicit Pooling (GrePool) method, which selects nodes by explicitly leveraging the relationships between the nodes and final representation vectors crucial for classification. The second issue is addressed using an extended version of GrePool (i.e., GrePool+), which applies a uniform loss on the discarded nodes. This addition is designed to augment the training process and improve classification accuracy. Furthermore, we conduct comprehensive experiments across 12 widely used datasets to validate our proposed method's effectiveness, including the Open Graph Benchmark datasets. Our experimental results uniformly demonstrate that GrePool outperforms 14 baseline methods for most datasets. Likewise, implementing GrePool+ enhances GrePool's performance without incurring additional computational costs.

Zihong Zhang, Liqi He, Zuchao Li et al.

Word segmentation stands as a cornerstone of Natural Language Processing (NLP). Based on the concept of "comprehend first, segment later", we propose a new framework to explore the limit of unsupervised word segmentation with Large Language Models (LLMs) and evaluate the semantic understanding capabilities of LLMs based on word segmentation. We employ current mainstream LLMs to perform word segmentation across multiple languages to assess LLMs' "comprehension". Our findings reveal that LLMs are capable of following simple prompts to segment raw text into words. There is a trend suggesting that models with more parameters tend to perform better on multiple languages. Additionally, we introduce a novel unsupervised method, termed LLACA ($\textbf{L}$arge $\textbf{L}$anguage Model-Inspired $\textbf{A}$ho-$\textbf{C}$orasick $\textbf{A}$utomaton). Leveraging the advanced pattern recognition capabilities of Aho-Corasick automata, LLACA innovatively combines these with the deep insights of well-pretrained LLMs. This approach not only enables the construction of a dynamic $n$-gram model that adjusts based on contextual information but also integrates the nuanced understanding of LLMs, offering significant improvements over traditional methods. Our source code is available at https://github.com/hkr04/LLACA

Di Wang, Meiqi Hu, Yao Jin et al.

Accurate hyperspectral image (HSI) interpretation is critical for providing valuable insights into various earth observation-related applications such as urban planning, precision agriculture, and environmental monitoring. However, existing HSI processing methods are predominantly task-specific and scene-dependent, which severely limits their ability to transfer knowledge across tasks and scenes, thereby reducing the practicality in real-world applications. To address these challenges, we present HyperSIGMA, a vision transformer-based foundation model that unifies HSI interpretation across tasks and scenes, scalable to over one billion parameters. To overcome the spectral and spatial redundancy inherent in HSIs, we introduce a novel sparse sampling attention (SSA) mechanism, which effectively promotes the learning of diverse contextual features and serves as the basic block of HyperSIGMA. HyperSIGMA integrates spatial and spectral features using a specially designed spectral enhancement module. In addition, we construct a large-scale hyperspectral dataset, HyperGlobal-450K, for pre-training, which contains about 450K hyperspectral images, significantly surpassing existing datasets in scale. Extensive experiments on various high-level and low-level HSI tasks demonstrate HyperSIGMA's versatility and superior representational capability compared to current state-of-the-art methods. Moreover, HyperSIGMA shows significant advantages in scalability, robustness, cross-modal transferring capability, real-world applicability, and computational efficiency. The code and models will be released at https://github.com/WHU-Sigma/HyperSIGMA.

Wentao Jiang, Jing Zhang, Di Wang et al.

Due to spatial redundancy in remote sensing images, sparse tokens containing rich information are usually involved in self-attention (SA) to reduce the overall token numbers within the calculation, avoiding the high computational cost issue in Vision Transformers. However, such methods usually obtain sparse tokens by hand-crafted or parallel-unfriendly designs, posing a challenge to reach a better balance between efficiency and performance. Different from them, this paper proposes to use learnable meta tokens to formulate sparse tokens, which effectively learn key information meanwhile improving the inference speed. Technically, the meta tokens are first initialized from image tokens via cross-attention. Then, we propose Dual Cross-Attention (DCA) to promote information exchange between image tokens and meta tokens, where they serve as query and key (value) tokens alternatively in a dual-branch structure, significantly reducing the computational complexity compared to self-attention. By employing DCA in the early stages with dense visual tokens, we obtain the hierarchical architecture LeMeViT with various sizes. Experimental results in classification and dense prediction tasks show that LeMeViT has a significant $1.7 \times$ speedup, fewer parameters, and competitive performance compared to the baseline models, and achieves a better trade-off between efficiency and performance.

Yang Zhao, Yuxiang Zhang, Yanni Dong et al.

Most change detection models based on vision transformers currently follow a "pretraining then fine-tuning" strategy. This involves initializing the model weights using large scale classification datasets, which can be either natural images or remote sensing images. However, fully tuning such a model requires significant time and resources. In this paper, we propose an efficient tuning approach that involves freezing the parameters of the pretrained image encoder and introducing additional training parameters. Through this approach, we have achieved competitive or even better results while maintaining extremely low resource consumption across six change detection benchmarks. For example, training time on LEVIR-CD, a change detection benchmark, is only half an hour with 9 GB memory usage, which could be very convenient for most researchers. Additionally, the decoupled tuning framework can be extended to any pretrained model for semantic change detection and multi temporal change detection as well. We hope that our proposed approach will serve as a part of foundational model to inspire more unified training approaches on change detection in the future.

Xingqiao Li, Jindong Gu, Zhiyong Wang et al.

Predicting in-hospital mortality for intensive care unit (ICU) patients is key to final clinical outcomes. AI has shown advantaged accuracy but suffers from the lack of explainability. To address this issue, this paper proposes an eXplainable Multimodal Mortality Predictor (X-MMP) approaching an efficient, explainable AI solution for predicting in-hospital mortality via multimodal ICU data. We employ multimodal learning in our framework, which can receive heterogeneous inputs from clinical data and make decisions. Furthermore, we introduce an explainable method, namely Layer-Wise Propagation to Transformer, as a proper extension of the LRP method to Transformers, producing explanations over multimodal inputs and revealing the salient features attributed to prediction. Moreover, the contribution of each modality to clinical outcomes can be visualized, assisting clinicians in understanding the reasoning behind decision-making. We construct a multimodal dataset based on MIMIC-III and MIMIC-III Waveform Database Matched Subset. Comprehensive experiments on benchmark datasets demonstrate that our proposed framework can achieve reasonable interpretation with competitive prediction accuracy. In particular, our framework can be easily transferred to other clinical tasks, which facilitates the discovery of crucial factors in healthcare research.

Wei Ma, Yixiao Yang, Qiang Hu et al.

Applications of Large Language Models~(LLMs) have evolved from simple text generators into complex software systems that integrate retrieval augmentation, tool invocation, and multi-turn interactions. Their inherent non-determinism, dynamism, and context dependence pose fundamental challenges for quality assurance. This paper decomposes LLM applications into a three-layer architecture: \textbf{\textit{System Shell Layer}}, \textbf{\textit{Prompt Orchestration Layer}}, and \textbf{\textit{LLM Inference Core}}. We then assess the applicability of traditional software testing methods in each layer: directly applicable at the shell layer, requiring semantic reinterpretation at the orchestration layer, and necessitating paradigm shifts at the inference core. A comparative analysis of Testing AI methods from the software engineering community and safety analysis techniques from the AI community reveals structural disconnects in testing unit abstraction, evaluation metrics, and lifecycle management. We identify four fundamental differences that underlie 6 core challenges. To address these, we propose four types of collaborative strategies (\emph{Retain}, \emph{Translate}, \emph{Integrate}, and \emph{Runtime}) and explore a closed-loop, trustworthy quality assurance framework that combines pre-deployment validation with runtime monitoring. Based on these strategies, we offer practical guidance and a protocol proposal to support the standardization and tooling of LLM application testing. We propose a protocol \textbf{\textit{Agent Interaction Communication Language}} (AICL) that is used to communicate between AI agents. AICL has the test-oriented features and is easily integrated in the current agent framework.

Qu Yang, Mang Ye, Bo Du

Multi-modal large language models (MLLMs) have achieved remarkable performance on objective multimodal perception tasks, but their ability to interpret subjective, emotionally nuanced multimodal content remains largely unexplored. Thus, it impedes their ability to effectively understand and react to the intricate emotions expressed by humans through multimodal media. To bridge this gap, we introduce EmoBench, the first comprehensive benchmark designed specifically to evaluate the emotional capabilities of MLLMs across five popular emotional tasks, using a diverse dataset of 287k images and videos paired with corresponding textual instructions. Meanwhile, we propose EmoLLM, a novel model for multimodal emotional understanding, incorporating with two core techniques. 1) Multi-perspective Visual Projection, it captures diverse emotional cues from visual data from multiple perspectives. 2) EmoPrompt, it guides MLLMs to reason about emotions in the correct direction. Experimental results demonstrate that EmoLLM significantly elevates multimodal emotional understanding performance, with an average improvement of 12.1% across multiple foundation models on EmoBench. Our work contributes to the advancement of MLLMs by facilitating a deeper and more nuanced comprehension of intricate human emotions, paving the way for the development of artificial emotional intelligence capabilities with wide-ranging applications in areas such as human-computer interaction, mental health support, and empathetic AI systems. Code, data, and model will be released.

Yunke Wang, Linwei Tao, Bo Du et al.

Adversarial Imitation Learning (AIL) allows the agent to reproduce expert behavior with low-dimensional states and actions. However, challenges arise in handling visual states due to their less distinguishable representation compared to low-dimensional proprioceptive features. While existing methods resort to adopt complex network architectures or separate the process of learning representation and decision-making, they overlook valuable intra-agent information within demonstrations. To address this problem, this paper proposes a simple and effective solution by incorporating calibrated contrastive representative learning into visual AIL framework. Specifically, we present an image encoder in visual AIL, utilizing a combination of unsupervised and supervised contrastive learning to extract valuable features from visual states. Based on the fact that the improved agent often produces demonstrations of varying quality, we propose to calibrate the contrastive loss by treating each agent demonstrations as a mixed sample. The incorporation of contrastive learning can be jointly optimized with the AIL framework, without modifying the architecture or incurring significant computational costs. Experimental results on DMControl Suite demonstrate our proposed method is sample efficient and can outperform other compared methods from different aspects.

Rui Xu, Yunke Wang, Bo Du

Unsupervised anomaly detection has gained significant attention in the field of medical imaging due to its capability of relieving the costly pixel-level annotation. To achieve this, modern approaches usually utilize generative models to produce healthy references of the diseased images and then identify the abnormalities by comparing the healthy references and the original diseased images. Recently, diffusion models have exhibited promising potential for unsupervised anomaly detection in medical images for their good mode coverage and high sample quality. However, the intrinsic characteristics of the medical images, e.g. the low contrast, and the intricate anatomical structure of the human body make the reconstruction challenging. Besides, the global information of medical images often remain underutilized. To address these two issues, we propose a novel Masked Autoencoder-enhanced Diffusion Model (MAEDiff) for unsupervised anomaly detection in brain images. The MAEDiff involves a hierarchical patch partition. It generates healthy images by overlapping upper-level patches and implements a mechanism based on the masked autoencoders operating on the sub-level patches to enhance the condition on the unnoised regions. Extensive experiments on data of tumors and multiple sclerosis lesions demonstrate the effectiveness of our method.