Peng Yao

Liang Xu, Pengwu Song, Shilu Zhu et al.

Continuous monitoring and in-situ assessment of microvascular connectivity have significant implications for culturing vascularized organoids and optimizing the therapeutic strategies. However, commonly used methods for vascular connectivity assessment heavily rely on fluorescent labels that may either raise biocompatibility concerns or interrupt the normal cell growth process. To address this issue, a Vessel Connectivity Network (VC-Net) was developed for label-free assessment of vascular connectivity. To validate the VC-Net, microvascular networks (MVNs) were cultured in vitro and their microscopic images were acquired at different culturing conditions as a training dataset. The VC-Net employs a Vessel Queue Contrastive Learning (VQCL) method and a class imbalance algorithm to address the issues of limited sample size, indistinctive class features and imbalanced class distribution in the dataset. The VC-Net successfully evaluated the vascular connectivity with no significant deviation from that by fluorescence imaging. In addition, the proposed VC-Net successfully differentiated the connectivity characteristics between normal and tumor-related MVNs. In comparison with those cultured in the regular microenvironment, the averaged connectivity of MVNs cultured in the tumor-related microenvironment decreased by 30.8%, whereas the non-connected area increased by 37.3%. This study provides a new avenue for label-free and continuous assessment of organoid or tumor vascularization in vitro.

Yu Shen, Yang Li, Jian Zheng et al.

Designing neural architectures requires immense manual efforts. This has promoted the development of neural architecture search (NAS) to automate the design. While previous NAS methods achieve promising results but run slowly, zero-cost proxies run extremely fast but are less promising. Therefore, it is of great potential to accelerate NAS via those zero-cost proxies. The existing method has two limitations, which are unforeseeable reliability and one-shot usage. To address the limitations, we present ProxyBO, an efficient Bayesian optimization (BO) framework that utilizes the zero-cost proxies to accelerate neural architecture search. We apply the generalization ability measurement to estimate the fitness of proxies on the task during each iteration and design a novel acquisition function to combine BO with zero-cost proxies based on their dynamic influence. Extensive empirical studies show that ProxyBO consistently outperforms competitive baselines on five tasks from three public benchmarks. Concretely, ProxyBO achieves up to 5.41x and 3.86x speedups over the state-of-the-art approaches REA and BRP-NAS.

Peng Yao, Shuwei Shen, Mengjuan Xu et al.

Deep convolutional neural network (DCNN) models have been widely explored for skin disease diagnosis and some of them have achieved the diagnostic outcomes comparable or even superior to those of dermatologists. However, broad implementation of DCNN in skin disease detection is hindered by small size and data imbalance of the publically accessible skin lesion datasets. This paper proposes a novel single-model based strategy for classification of skin lesions on small and imbalanced datasets. First, various DCNNs are trained on different small and imbalanced datasets to verify that the models with moderate complexity outperform the larger models. Second, regularization DropOut and DropBlock are added to reduce overfitting and a Modified RandAugment augmentation strategy is proposed to deal with the defects of sample underrepresentation in the small dataset. Finally, a novel Multi-Weighted New Loss (MWNL) function and an end-to-end cumulative learning strategy (CLS) are introduced to overcome the challenge of uneven sample size and classification difficulty and to reduce the impact of abnormal samples on training. By combining Modified RandAugment, MWNL and CLS, our single DCNN model method achieved the classification accuracy comparable or superior to those of multiple ensembling models on different dermoscopic image datasets. Our study shows that this method is able to achieve a high classification performance at a low cost of computational resources and inference time, potentially suitable to implement in mobile devices for automated screening of skin lesions and many other malignancies in low resource settings.

Shuwei Shen, Mengjuan Xu, Fan Zhang et al.

Although deep convolutional neural networks (DCNNs) have achieved significant accuracy in skin lesion classification comparable or even superior to those of dermatologists, practical implementation of these models for skin cancer screening in low resource settings is hindered by their limitations in computational cost and training dataset. To overcome these limitations, we propose a low-cost and high-performance data augmentation strategy that includes two consecutive stages of augmentation search and network search. At the augmentation search stage, the augmentation strategy is optimized in the search space of Low-Cost-Augment (LCA) under the criteria of balanced accuracy (BACC) with 5-fold cross validation. At the network search stage, the DCNNs are fine-tuned with the full training set in order to select the model with the highest BACC. The efficiency of the proposed data augmentation strategy is verified on the HAM10000 dataset using EfficientNets as a baseline. With the proposed strategy, we are able to reduce the search space to 60 and achieve a high BACC of 0.853 by using a single DCNN model without external database, suitable to be implemented in mobile devices for DCNN-based skin lesion detection in low resource settings.

Longteng Guo, Jing Liu, Xinxin Zhu et al.

Self-attention (SA) network has shown profound value in image captioning. In this paper, we improve SA from two aspects to promote the performance of image captioning. First, we propose Normalized Self-Attention (NSA), a reparameterization of SA that brings the benefits of normalization inside SA. While normalization is previously only applied outside SA, we introduce a novel normalization method and demonstrate that it is both possible and beneficial to perform it on the hidden activations inside SA. Second, to compensate for the major limit of Transformer that it fails to model the geometry structure of the input objects, we propose a class of Geometry-aware Self-Attention (GSA) that extends SA to explicitly and efficiently consider the relative geometry relations between the objects in the image. To construct our image captioning model, we combine the two modules and apply it to the vanilla self-attention network. We extensively evaluate our proposals on MS-COCO image captioning dataset and superior results are achieved when comparing to state-of-the-art approaches. Further experiments on three challenging tasks, i.e. video captioning, machine translation, and visual question answering, show the generality of our methods.