Junjie Hu

Yu-Xin Jin, Jun-Jie Hu, Qi Li et al.

New COVID-19 epidemic strains like Delta and Omicron with increased transmissibility and pathogenicity emerge and spread across the whole world rapidly while causing high mortality during the pandemic period. Early prediction of possible variants (especially spike protein) of COVID-19 epidemic strains based on available mutated SARS-CoV-2 RNA sequences may lead to early prevention and treatment. Here, combining the advantage of quantum and quantum-inspired algorithms with the wide application of deep learning, we propose a development tool named DeepQuantum, and use this software to realize the goal of predicting spike protein variation structure of COVID-19 epidemic strains. In addition, this hybrid quantum-classical model for the first time achieves quantum-inspired blur convolution similar to classical depthwise convolution and also successfully applies quantum progressive training with quantum circuits, both of which guarantee that our model is the quantum counterpart of the famous style-based GAN. The results state that the fidelities of random generating spike protein variation structure are always beyond 96% for Delta, 94% for Omicron. The training loss curve is more stable and converges better with multiple loss functions compared with the corresponding classical algorithm. At last, evidences that quantum-inspired algorithms promote the classical deep learning and hybrid models effectively predict the mutant strains are strong.

Zachary Huemann, Changhee Lee, Junjie Hu et al.

With the growing use of transformer-based language models in medicine, it is unclear how well these models generalize to nuclear medicine which has domain-specific vocabulary and unique reporting styles. In this study, we evaluated the value of domain adaptation in nuclear medicine by adapting language models for the purpose of 5-point Deauville score prediction based on clinical 18F-fluorodeoxyglucose (FDG) PET/CT reports. We retrospectively retrieved 4542 text reports and 1664 images for FDG PET/CT lymphoma exams from 2008-2018 in our clinical imaging database. Deauville scores were removed from the reports and then the remaining text in the reports was used as the model input. Multiple general-purpose transformer language models were used to classify the reports into Deauville scores 1-5. We then adapted the models to the nuclear medicine domain using masked language modeling and assessed its impact on classification performance. The language models were compared against vision models, a multimodal vision language model, and a nuclear medicine physician with seven-fold Monte Carlo cross validation, reported are the mean and standard deviations. Domain adaption improved all language models. For example, BERT improved from 61.3% five-class accuracy to 65.7% following domain adaptation. The best performing model (domain-adapted RoBERTa) achieved a five-class accuracy of 77.4%, which was better than the physician's performance (66%), the best vision model's performance (48.1), and was similar to the multimodal model's performance (77.2). Domain adaptation improved the performance of large language models in interpreting nuclear medicine text reports.

Liguang Zhou, Junjie Hu, Yuhongze Zhou et al.

Unbiased scene graph generation (USGG) is a challenging task that requires predicting diverse and heavily imbalanced predicates between objects in an image. To address this, we propose a novel framework peer learning that uses predicate sampling and consensus voting (PSCV) to encourage multiple peers to learn from each other. Predicate sampling divides the predicate classes into sub-distributions based on frequency, and assigns different peers to handle each sub-distribution or combinations of them. Consensus voting ensembles the peers' complementary predicate knowledge by emphasizing majority opinion and diminishing minority opinion. Experiments on Visual Genome show that PSCV outperforms previous methods and achieves a new state-of-the-art on SGCls task with 31.6 mean.

Tuan Dinh, Jy-yong Sohn, Shashank Rajput et al.

Word translation without parallel corpora has become feasible, rivaling the performance of supervised methods. Recent findings have shown that the accuracy and robustness of unsupervised word translation (UWT) can be improved by making use of visual observations, which are universal representations across languages. In this work, we investigate the potential of using not only visual observations but also pretrained language-image models for enabling a more efficient and robust UWT. Specifically, we develop a novel UWT method dubbed Word Alignment using Language-Image Pretraining (WALIP), which leverages visual observations via the shared embedding space of images and texts provided by CLIP models (Radford et al., 2021). WALIP has a two-step procedure. First, we retrieve word pairs with high confidences of similarity, computed using our proposed image-based fingerprints, which define the initial pivot for the word alignment. Second, we apply our robust Procrustes algorithm to estimate the linear mapping between two embedding spaces, which iteratively corrects and refines the estimated alignment. Our extensive experiments show that WALIP improves upon the state-of-the-art performance of bilingual word alignment for a few language pairs across different word embeddings and displays great robustness to the dissimilarity of language pairs or training corpora for two word embeddings.

Zachary Huemann, Xin Tie, Junjie Hu et al.

Radiology narrative reports often describe characteristics of a patient's disease, including its location, size, and shape. Motivated by the recent success of multimodal learning, we hypothesized that this descriptive text could guide medical image analysis algorithms. We proposed a novel vision-language model, ConTEXTual Net, for the task of pneumothorax segmentation on chest radiographs. ConTEXTual Net utilizes language features extracted from corresponding free-form radiology reports using a pre-trained language model. Cross-attention modules are designed to combine the intermediate output of each vision encoder layer and the text embeddings generated by the language model. ConTEXTual Net was trained on the CANDID-PTX dataset consisting of 3,196 positive cases of pneumothorax with segmentation annotations from 6 different physicians as well as clinical radiology reports. Using cross-validation, ConTEXTual Net achieved a Dice score of 0.716$\pm$0.016, which was similar to the degree of inter-reader variability (0.712$\pm$0.044) computed on a subset of the data. It outperformed both vision-only models (ResNet50 U-Net: 0.677$\pm$0.015 and GLoRIA: 0.686$\pm$0.014) and a competing vision-language model (LAVT: 0.706$\pm$0.009). Ablation studies confirmed that it was the text information that led to the performance gains. Additionally, we show that certain augmentation methods degraded ConTEXTual Net's segmentation performance by breaking the image-text concordance. We also evaluated the effects of using different language models and activation functions in the cross-attention module, highlighting the efficacy of our chosen architectural design.

Yun Wang, Longguang Wang, Chenghao Zhang et al.

Recently, learning-based stereo matching networks have advanced significantly. However, they often lack robustness and struggle to achieve impressive cross-domain performance due to domain shifts and imbalanced disparity distributions among diverse datasets. Leveraging Vision Foundation Models (VFMs) can intuitively enhance the model's robustness, but integrating such a model into stereo matching cost-effectively to fully realize their robustness remains a key challenge. To address this, we propose SMoEStereo, a novel framework that adapts VFMs for stereo matching through a tailored, scene-specific fusion of Low-Rank Adaptation (LoRA) and Mixture-of-Experts (MoE) modules. SMoEStereo introduces MoE-LoRA with adaptive ranks and MoE-Adapter with adaptive kernel sizes. The former dynamically selects optimal experts within MoE to adapt varying scenes across domains, while the latter injects inductive bias into frozen VFMs to improve geometric feature extraction. Importantly, to mitigate computational overhead, we further propose a lightweight decision network that selectively activates MoE modules based on input complexity, balancing efficiency with accuracy. Extensive experiments demonstrate that our method exhibits state-of-the-art cross-domain and joint generalization across multiple benchmarks without dataset-specific adaptation. The code is available at \textcolor{red}{https://github.com/cocowy1/SMoE-Stereo}.

Qishan Wang, Shuyong Gao, Junjie Hu et al.

Multi-class Unsupervised Anomaly Detection algorithms (MUAD) are receiving increasing attention due to their relatively low deployment costs and improved training efficiency. However, the real-world effectiveness of MUAD methods is questioned due to limitations in current Industrial Anomaly Detection (IAD) datasets. These datasets contain numerous classes that are unlikely to be produced by the same factory and fail to cover multiple structures or appearances. Additionally, the defects do not reflect real-world characteristics. Therefore, we introduce the Heterogeneous Same-Sort Industrial Anomaly Detection (HSS-IAD) dataset, which contains 8,580 images of metallic-like industrial parts and precise anomaly annotations. These parts exhibit variations in structure and appearance, with subtle defects that closely resemble the base materials. We also provide foreground images for synthetic anomaly generation. Finally, we evaluate popular IAD methods on this dataset under multi-class and class-separated settings, demonstrating its potential to bridge the gap between existing datasets and real factory conditions. The dataset is available at https://github.com/Qiqigeww/HSS-IAD-Dataset.

Qishan Wang, Jia Guo, Shuyong Gao et al.

Few-shot anomaly detection (FSAD) has emerged as a crucial yet challenging task in industrial inspection, where normal distribution modeling must be accomplished with only a few normal images. While existing approaches typically employ multi-modal foundation models combining language and vision modalities for prompt-guided anomaly detection, these methods often demand sophisticated prompt engineering and extensive manual tuning. In this paper, we demonstrate that a straightforward nearest-neighbor search framework can surpass state-of-the-art performance in both single-class and multi-class FSAD scenarios. Our proposed method, VisionAD, consists of four simple yet essential components: (1) scalable vision foundation models that extract universal and discriminative features; (2) dual augmentation strategies - support augmentation to enhance feature matching adaptability and query augmentation to address the oversights of single-view prediction; (3) multi-layer feature integration that captures both low-frequency global context and high-frequency local details with minimal computational overhead; and (4) a class-aware visual memory bank enabling efficient one-for-all multi-class detection. Extensive evaluations across MVTec-AD, VisA, and Real-IAD benchmarks demonstrate VisionAD's exceptional performance. Using only 1 normal images as support, our method achieves remarkable image-level AUROC scores of 97.4%, 94.8%, and 70.8% respectively, outperforming current state-of-the-art approaches by significant margins (+1.6%, +3.2%, and +1.4%). The training-free nature and superior few-shot capabilities of VisionAD make it particularly appealing for real-world applications where samples are scarce or expensive to obtain. Code is available at https://github.com/Qiqigeww/VisionAD.

Shengqian Zhu, Chengrong Yu, Qiang Wang et al.

Class incremental medical image segmentation (CIMIS) aims to preserve knowledge of previously learned classes while learning new ones without relying on old-class labels. However, existing methods 1) either adopt one-size-fits-all strategies that treat all spatial regions and feature channels equally, which may hinder the preservation of accurate old knowledge, 2) or focus solely on aligning local prototypes with global ones for old classes while overlooking their local representations in new data, leading to knowledge degradation. To mitigate the above issues, we propose Prototype-Guided Calibration Distillation (PGCD) and Dual-Aligned Prototype Distillation (DAPD) for CIMIS in this paper. Specifically, PGCD exploits prototype-to-feature similarity to calibrate class-specific distillation intensity in different spatial regions, effectively reinforcing reliable old knowledge and suppressing misleading information from old classes. Complementarily, DAPD aligns the local prototypes of old classes extracted from the current model with both global prototypes and local prototypes, further enhancing segmentation performance on old categories. Comprehensive evaluations on two widely used multi-organ segmentation benchmarks demonstrate that our method outperforms state-of-the-art methods, highlighting its robustness and generalization capabilities.

Xin Tie, Muheon Shin, Changhee Lee et al.

$\textbf{Purpose}$: Automatic quantification of longitudinal changes in PET scans for lymphoma patients has proven challenging, as residual disease in interim-therapy scans is often subtle and difficult to detect. Our goal was to develop a longitudinally-aware segmentation network (LAS-Net) that can quantify serial PET/CT images for pediatric Hodgkin lymphoma patients. $\textbf{Materials and Methods}$: This retrospective study included baseline (PET1) and interim (PET2) PET/CT images from 297 patients enrolled in two Children's Oncology Group clinical trials (AHOD1331 and AHOD0831). LAS-Net incorporates longitudinal cross-attention, allowing relevant features from PET1 to inform the analysis of PET2. Model performance was evaluated using Dice coefficients for PET1 and detection F1 scores for PET2. Additionally, we extracted and compared quantitative PET metrics, including metabolic tumor volume (MTV) and total lesion glycolysis (TLG) in PET1, as well as qPET and $Δ$SUVmax in PET2, against physician measurements. We quantified their agreement using Spearman's $ρ$ correlations and employed bootstrap resampling for statistical analysis. $\textbf{Results}$: LAS-Net detected residual lymphoma in PET2 with an F1 score of 0.606 (precision/recall: 0.615/0.600), outperforming all comparator methods (P<0.01). For baseline segmentation, LAS-Net achieved a mean Dice score of 0.772. In PET quantification, LAS-Net's measurements of qPET, $Δ$SUVmax, MTV and TLG were strongly correlated with physician measurements, with Spearman's $ρ$ of 0.78, 0.80, 0.93 and 0.96, respectively. The performance remained high, with a slight decrease, in an external testing cohort. $\textbf{Conclusion}$: LAS-Net demonstrated significant improvements in quantifying PET metrics across serial scans, highlighting the value of longitudinal awareness in evaluating multi-time-point imaging datasets.

Zachary Huemann, Samuel Church, Joshua D. Warner et al.

Vision-language models can connect the text description of an object to its specific location in an image through visual grounding. This has potential applications in enhanced radiology reporting. However, these models require large annotated image-text datasets, which are lacking for PET/CT. We developed an automated pipeline to generate weak labels linking PET/CT report descriptions to their image locations and used it to train a 3D vision-language visual grounding model. Our pipeline finds positive findings in PET/CT reports by identifying mentions of SUVmax and axial slice numbers. From 25,578 PET/CT exams, we extracted 11,356 sentence-label pairs. Using this data, we trained ConTEXTual Net 3D, which integrates text embeddings from a large language model with a 3D nnU-Net via token-level cross-attention. The model's performance was compared against LLMSeg, a 2.5D version of ConTEXTual Net, and two nuclear medicine physicians. The weak-labeling pipeline accurately identified lesion locations in 98% of cases (246/251), with 7.5% requiring boundary adjustments. ConTEXTual Net 3D achieved an F1 score of 0.80, outperforming LLMSeg (F1=0.22) and the 2.5D model (F1=0.53), though it underperformed both physicians (F1=0.94 and 0.91). The model achieved better performance on FDG (F1=0.78) and DCFPyL (F1=0.75) exams, while performance dropped on DOTATE (F1=0.58) and Fluciclovine (F1=0.66). The model performed consistently across lesion sizes but showed reduced accuracy on lesions with low uptake. Our novel weak labeling pipeline accurately produced an annotated dataset of PET/CT image-text pairs, facilitating the development of 3D visual grounding models. ConTEXTual Net 3D significantly outperformed other models but fell short of the performance of nuclear medicine physicians. Our study suggests that even larger datasets may be needed to close this performance gap.

Yuang Feng, Shuyong Gao, Fuzhen Yan et al.

Video Camouflaged Object Detection (VCOD) aims to segment objects whose appearances closely resemble their surroundings, posing a challenging and emerging task. Existing vision models often struggle in such scenarios due to the indistinguishable appearance of camouflaged objects and the insufficient exploitation of dynamic information in videos. To address these challenges, we propose an end-to-end VCOD framework inspired by human memory-recognition, which leverages historical video information by integrating memory reference frames for camouflaged sequence processing. Specifically, we design a dual-purpose decoder that simultaneously generates predicted masks and scores, enabling reference frame selection based on scores while introducing auxiliary supervision to enhance feature extraction.Furthermore, this study introduces a novel reference-guided multilevel asymmetric attention mechanism, effectively integrating long-term reference information with short-term motion cues for comprehensive feature extraction. By combining these modules, we develop the Scoring, Remember, and Reference (SRR) framework, which efficiently extracts information to locate targets and employs memory guidance to improve subsequent processing. With its optimized module design and effective utilization of video data, our model achieves significant performance improvements, surpassing existing approaches by 10% on benchmark datasets while requiring fewer parameters (54M) and only a single pass through the video. The code will be made publicly available.

Junjie Hu, Shuyong Gao, Qianyu Guo et al.

Humans can intuitively decompose an image into a sequence of strokes to create a painting, yet existing methods for generating drawing processes are limited to specific data types and often rely on expensive human-annotated datasets. We propose a novel self-supervised framework for generating drawing processes from any type of image, treating the task as a video generation problem. Our approach reverses the drawing process by progressively removing strokes from a reference image, simulating a human-like creation sequence. Crucially, our method does not require costly datasets of real human drawing processes; instead, we leverage depth estimation and stroke rendering to construct a self-supervised dataset. We model human drawings as "refinement" and "layering" processes and introduce depth fusion layers to enable video generation models to learn and replicate human drawing behavior. Extensive experiments validate the effectiveness of our approach, demonstrating its ability to generate realistic drawings without the need for real drawing process data.

Po-Yao Huang, Junjie Hu, Xiaojun Chang et al.

Unsupervised machine translation (MT) has recently achieved impressive results with monolingual corpora only. However, it is still challenging to associate source-target sentences in the latent space. As people speak different languages biologically share similar visual systems, the potential of achieving better alignment through visual content is promising yet under-explored in unsupervised multimodal MT (MMT). In this paper, we investigate how to utilize visual content for disambiguation and promoting latent space alignment in unsupervised MMT. Our model employs multimodal back-translation and features pseudo visual pivoting in which we learn a shared multilingual visual-semantic embedding space and incorporate visually-pivoted captioning as additional weak supervision. The experimental results on the widely used Multi30K dataset show that the proposed model significantly improves over the state-of-the-art methods and generalizes well when the images are not available at the testing time.

Ming Jiang, Junjie Hu, Qiuyuan Huang et al.

Popular metrics used for evaluating image captioning systems, such as BLEU and CIDEr, provide a single score to gauge the system's overall effectiveness. This score is often not informative enough to indicate what specific errors are made by a given system. In this study, we present a fine-grained evaluation method REO for automatically measuring the performance of image captioning systems. REO assesses the quality of captions from three perspectives: 1) Relevance to the ground truth, 2) Extraness of the content that is irrelevant to the ground truth, and 3) Omission of the elements in the images and human references. Experiments on three benchmark datasets demonstrate that our method achieves a higher consistency with human judgments and provides more intuitive evaluation results than alternative metrics.