Danilo Carvalho

Edoardo Manino, Julia Rozanova, Danilo Carvalho et al.

Metamorphic testing has recently been used to check the safety of neural NLP models. Its main advantage is that it does not rely on a ground truth to generate test cases. However, existing studies are mostly concerned with robustness-like metamorphic relations, limiting the scope of linguistic properties they can test. We propose three new classes of metamorphic relations, which address the properties of systematicity, compositionality and transitivity. Unlike robustness, our relations are defined over multiple source inputs, thus increasing the number of test cases that we can produce by a polynomial factor. With them, we test the internal consistency of state-of-the-art NLP models, and show that they do not always behave according to their expected linguistic properties. Lastly, we introduce a novel graphical notation that efficiently summarises the inner structure of metamorphic relations.

Magdalena Wysocka, Danilo Carvalho, Oskar Wysocki et al.

Syllogistic reasoning is crucial for Natural Language Inference (NLI). This capability is particularly significant in specialized domains such as biomedicine, where it can support automatic evidence interpretation and scientific discovery. This paper presents SylloBio-NLI, a novel framework that leverages external ontologies to systematically instantiate diverse syllogistic arguments for biomedical NLI. We employ SylloBio-NLI to evaluate Large Language Models (LLMs) on identifying valid conclusions and extracting supporting evidence across 28 syllogistic schemes instantiated with human genome pathways. Extensive experiments reveal that biomedical syllogistic reasoning is particularly challenging for zero-shot LLMs, which achieve an average accuracy between 70% on generalized modus ponens and 23% on disjunctive syllogism. At the same time, we found that few-shot prompting can boost the performance of different LLMs, including Gemma (+14%) and LLama-3 (+43%). However, a deeper analysis shows that both techniques exhibit high sensitivity to superficial lexical variations, highlighting a dependency between reliability, models' architecture, and pre-training regime. Overall, our results indicate that, while in-context examples have the potential to elicit syllogistic reasoning in LLMs, existing models are still far from achieving the robustness and consistency required for safe biomedical NLI applications.

Oskar Wysocki, Magdalena Wysocka, Danilo Carvalho et al.

We present BioLunar, developed using the Lunar framework, as a tool for supporting biological analyses, with a particular emphasis on molecular-level evidence enrichment for biomarker discovery in oncology. The platform integrates Large Language Models (LLMs) to facilitate complex scientific reasoning across distributed evidence spaces, enhancing the capability for harmonizing and reasoning over heterogeneous data sources. Demonstrating its utility in cancer research, BioLunar leverages modular design, reusable data access and data analysis components, and a low-code user interface, enabling researchers of all programming levels to construct LLM-enabled scientific workflows. By facilitating automatic scientific discovery and inference from heterogeneous evidence, BioLunar exemplifies the potential of the integration between LLMs, specialised databases and biomedical tools to support expert-level knowledge synthesis and discovery.