Zimeng Li

Zimeng Li, Shichao Zhu, Bin Shao et al.

Drug-drug interaction (DDI) prediction provides a drug combination strategy for systemically effective treatment. Previous studies usually model drug information constrained on a single view such as the drug itself, leading to incomplete and noisy information, which limits the accuracy of DDI prediction. In this work, we propose a novel multi- view drug substructure network for DDI prediction (MSN-DDI), which learns chemical substructures from both the representations of the single drug (intra-view) and the drug pair (inter-view) simultaneously and utilizes the substructures to update the drug representation iteratively. Comprehensive evaluations demonstrate that MSN-DDI has almost solved DDI prediction for existing drugs by achieving a relatively improved accuracy of 19.32% and an over 99% accuracy under the transductive setting. More importantly, MSN-DDI exhibits better generalization ability to unseen drugs with a relatively improved accuracy of 7.07% under more challenging inductive scenarios. Finally, MSN-DDI improves prediction performance for real-world DDI applications to new drugs.

Xiaojiao Guo, Yihang Dong, Xuhang Chen et al.

Underwater Image Restoration (UIR) remains a challenging task in computer vision due to the complex degradation of images in underwater environments. While recent approaches have leveraged various deep learning techniques, including Transformers and complex, parameter-heavy models to achieve significant improvements in restoration effects, we demonstrate that pure CNN architectures with lightweight parameters can achieve comparable results. In this paper, we introduce UIR-PolyKernel, a novel method for underwater image restoration that leverages Polymorphic Large Kernel CNNs. Our approach uniquely combines large kernel convolutions of diverse sizes and shapes to effectively capture long-range dependencies within underwater imagery. Additionally, we introduce a Hybrid Domain Attention module that integrates frequency and spatial domain attention mechanisms to enhance feature importance. By leveraging the frequency domain, we can capture hidden features that may not be perceptible to humans but are crucial for identifying patterns in both underwater and on-air images. This approach enhances the generalization and robustness of our UIR model. Extensive experiments on benchmark datasets demonstrate that UIR-PolyKernel achieves state-of-the-art performance in underwater image restoration tasks, both quantitatively and qualitatively. Our results show that well-designed pure CNN architectures can effectively compete with more complex models, offering a balance between performance and computational efficiency. This work provides new insights into the potential of CNN-based approaches for challenging image restoration tasks in underwater environments. The code is available at \href{https://github.com/CXH-Research/UIR-PolyKernel}{https://github.com/CXH-Research/UIR-PolyKernel}.