R. N. Tandon

Noel Teku, Fengwei Tian, Payel Bhattacharjee et al.

Alignment is a key step in developing Large Language Models (LLMs) using human feedback to ensure adherence to human values and societal norms. Dependence on human feedback raises privacy concerns about how much a labeler's preferences may reveal about their personal values, beliefs, and personality traits. Existing approaches, such as Differentially Private SGD (DP-SGD), provide rigorous privacy guarantees by privatizing gradients during fine-tuning and alignment but can provide more privacy than necessary as human preferences are tied only to labels of (prompt, response) pairs and can degrade model utility. This work focuses on LLM alignment with preference-level privacy, which preserves the privacy of preference labels provided by humans. We propose PROPS (PROgressively Private Self-alignment), a multi-stage privacy preserving alignment framework where privately aligned models in previous stages can serve as labelers for supplementing training data in the subsequent stages of alignment. We present theoretical guarantees for PROPS as well as comprehensive validation using multiple models (Pythia and GPT) and datasets (AlpacaEval, Anthropic HH-RLHF, truthy-dpo-v0.1) to demonstrate the utility of PROPS over existing methods while still providing high privacy. For the same privacy budget, alignment via PROPS can achieve up to 3x higher win-rates compared to DP-SGD, and 2.5x higher win-rates compared to Randomized Response (RR) based alignment.

Payel Bhattacharjee, Fengwei Tian, Geoffrey D. Rubin et al.

Purpose: This study proposes a framework for fine-tuning large language models (LLMs) with differential privacy (DP) to perform multi-abnormality classification on radiology report text. By injecting calibrated noise during fine-tuning, the framework seeks to mitigate the privacy risks associated with sensitive patient data and protect against data leakage while maintaining classification performance. Materials and Methods: We used 50,232 radiology reports from the publicly available MIMIC-CXR chest radiography and CT-RATE computed tomography datasets, collected between 2011 and 2019. Fine-tuning of LLMs was conducted to classify 14 labels from MIMIC-CXR dataset, and 18 labels from CT-RATE dataset using Differentially Private Low-Rank Adaptation (DP-LoRA) in high and moderate privacy regimes (across a range of privacy budgets = {0.01, 0.1, 1.0, 10.0}). Model performance was evaluated using weighted F1 score across three model architectures: BERT-medium, BERT-small, and ALBERT-base. Statistical analyses compared model performance across different privacy levels to quantify the privacy-utility trade-off. Results: We observe a clear privacy-utility trade-off through our experiments on 2 different datasets and 3 different models. Under moderate privacy guarantees the DP fine-tuned models achieved comparable weighted F1 scores of 0.88 on MIMIC-CXR and 0.59 on CT-RATE, compared to non-private LoRA baselines of 0.90 and 0.78, respectively. Conclusion: Differentially private fine-tuning using LoRA enables effective and privacy-preserving multi-abnormality classification from radiology reports, addressing a key challenge in fine-tuning LLMs on sensitive medical data.