Ruiyang Zhang

Jianing Qiu, Lin Li, Jiankai Sun et al.

Large AI models, or foundation models, are models recently emerging with massive scales both parameter-wise and data-wise, the magnitudes of which can reach beyond billions. Once pretrained, large AI models demonstrate impressive performance in various downstream tasks. A prime example is ChatGPT, whose capability has compelled people's imagination about the far-reaching influence that large AI models can have and their potential to transform different domains of our lives. In health informatics, the advent of large AI models has brought new paradigms for the design of methodologies. The scale of multi-modal data in the biomedical and health domain has been ever-expanding especially since the community embraced the era of deep learning, which provides the ground to develop, validate, and advance large AI models for breakthroughs in health-related areas. This article presents a comprehensive review of large AI models, from background to their applications. We identify seven key sectors in which large AI models are applicable and might have substantial influence, including 1) bioinformatics; 2) medical diagnosis; 3) medical imaging; 4) medical informatics; 5) medical education; 6) public health; and 7) medical robotics. We examine their challenges, followed by a critical discussion about potential future directions and pitfalls of large AI models in transforming the field of health informatics.

Ruiyang Zhang, Hu Zhang, Hang Yu et al.

The unsupervised 3D object detection is to accurately detect objects in unstructured environments with no explicit supervisory signals. This task, given sparse LiDAR point clouds, often results in compromised performance for detecting distant or small objects due to the inherent sparsity and limited spatial resolution. In this paper, we are among the early attempts to integrate LiDAR data with 2D images for unsupervised 3D detection and introduce a new method, dubbed LiDAR-2D Self-paced Learning (LiSe). We argue that RGB images serve as a valuable complement to LiDAR data, offering precise 2D localization cues, particularly when scarce LiDAR points are available for certain objects. Considering the unique characteristics of both modalities, our framework devises a self-paced learning pipeline that incorporates adaptive sampling and weak model aggregation strategies. The adaptive sampling strategy dynamically tunes the distribution of pseudo labels during training, countering the tendency of models to overfit easily detected samples, such as nearby and large-sized objects. By doing so, it ensures a balanced learning trajectory across varying object scales and distances. The weak model aggregation component consolidates the strengths of models trained under different pseudo label distributions, culminating in a robust and powerful final model. Experimental evaluations validate the efficacy of our proposed LiSe method, manifesting significant improvements of +7.1% AP$_{BEV}$ and +3.4% AP$_{3D}$ on nuScenes, and +8.3% AP$_{BEV}$ and +7.4% AP$_{3D}$ on Lyft compared to existing techniques.

Ruiyang Zhang, Hu Zhang, Hang Yu et al.

Unsupervised 3D object detection aims to identify objects of interest from unlabeled raw data, such as LiDAR points. Recent approaches usually adopt pseudo 3D bounding boxes (3D bboxes) from clustering algorithm to initialize the model training. However, pseudo bboxes inevitably contain noise, and such inaccuracies accumulate to the final model, compromising the performance. Therefore, in an attempt to mitigate the negative impact of inaccurate pseudo bboxes, we introduce a new uncertainty-aware framework for unsupervised 3D object detection, dubbed UA3D. In particular, our method consists of two phases: uncertainty estimation and uncertainty regularization. (1) In the uncertainty estimation phase, we incorporate an extra auxiliary detection branch alongside the original primary detector. The prediction disparity between the primary and auxiliary detectors could reflect fine-grained uncertainty at the box coordinate level. (2) Based on the assessed uncertainty, we adaptively adjust the weight of every 3D bbox coordinate via uncertainty regularization, refining the training process on pseudo bboxes. For pseudo bbox coordinate with high uncertainty, we assign a relatively low loss weight. Extensive experiments verify that the proposed method is robust against the noisy pseudo bboxes, yielding substantial improvements on nuScenes and Lyft compared to existing approaches, with increases of +6.9% AP$_{BEV}$ and +2.5% AP$_{3D}$ on nuScenes, and +4.1% AP$_{BEV}$ and +2.0% AP$_{3D}$ on Lyft.

Ruiyang Zhang, Hu Zhang, Hao Fei et al.

Large Multimodal Models (LMMs), harnessing the complementarity among diverse modalities, are often considered more robust than pure Language Large Models (LLMs); yet do LMMs know what they do not know? There are three key open questions remaining: (1) how to evaluate the uncertainty of diverse LMMs in a unified manner, (2) how to prompt LMMs to show its uncertainty, and (3) how to quantify uncertainty for downstream tasks. In an attempt to address these challenges, we introduce Uncertainty-o: (1) a model-agnostic framework designed to reveal uncertainty in LMMs regardless of their modalities, architectures, or capabilities, (2) an empirical exploration of multimodal prompt perturbations to uncover LMM uncertainty, offering insights and findings, and (3) derive the formulation of multimodal semantic uncertainty, which enables quantifying uncertainty from multimodal responses. Experiments across 18 benchmarks spanning various modalities and 10 LMMs (both open- and closed-source) demonstrate the effectiveness of Uncertainty-o in reliably estimating LMM uncertainty, thereby enhancing downstream tasks such as hallucination detection, hallucination mitigation, and uncertainty-aware Chain-of-Thought reasoning.