Ruijie Yang

Hao Quan, Xingyu Li, Weixing Chen et al.

Based on digital pathology slice scanning technology, artificial intelligence algorithms represented by deep learning have achieved remarkable results in the field of computational pathology. Compared to other medical images, pathology images are more difficult to annotate, and thus, there is an extreme lack of available datasets for conducting supervised learning to train robust deep learning models. In this paper, we propose a self-supervised learning (SSL) model, the global contrast-masked autoencoder (GCMAE), which can train the encoder to have the ability to represent local-global features of pathological images, also significantly improve the performance of transfer learning across data sets. In this study, the ability of the GCMAE to learn migratable representations was demonstrated through extensive experiments using a total of three different disease-specific hematoxylin and eosin (HE)-stained pathology datasets: Camelyon16, NCTCRC and BreakHis. In addition, this study designed an effective automated pathology diagnosis process based on the GCMAE for clinical applications. The source code of this paper is publicly available at https://github.com/StarUniversus/gcmae.

Ruijie Yang, Yan Zhu, Peiyao Fu et al.

Automatic speech recognition (ASR) is a critical interface for human-AI interaction in gastrointestinal endoscopy, yet its reliability in real-world clinical settings is limited by domain-specific terminology and complex acoustic conditions. Here, we present EndoASR, a domain-adapted ASR system designed for real-time deployment in endoscopic workflows. We develop a two-stage adaptation strategy based on synthetic endoscopy reports, targeting domain-specific language modeling and noise robustness. In retrospective evaluation across six endoscopists, EndoASR substantially improves both transcription accuracy and clinical usability, reducing character error rate (CER) from 20.52% to 14.14% and increasing medical term accuracy (Med ACC) from 54.30% to 87.59%. In a prospective multi-center study spanning five independent endoscopy centers, EndoASR demonstrates consistent generalization under heterogeneous real-world conditions. Compared with the baseline Paraformer model, CER is reduced from 16.20% to 14.97%, while Med ACC is improved from 61.63% to 84.16%, confirming its robustness in practical deployment scenarios. Notably, EndoASR achieves a real-time factor (RTF) of 0.005, significantly faster than Whisper-large-v3 (RTF 0.055), while maintaining a compact model size of 220M parameters, enabling efficient edge deployment. Furthermore, integration with large language models demonstrates that improved ASR quality directly enhances downstream structured information extraction and clinician-AI interaction. These results demonstrate that domain-adapted ASR can serve as a reliable interface for human-AI teaming in gastrointestinal endoscopy, with consistent performance validated across multi-center real-world clinical settings.

Guohao Li, Hongyu Yang, Yifang Men et al.

Generating animatable and editable 3D head avatars is essential for various applications in computer vision and graphics. Traditional 3D-aware generative adversarial networks (GANs), often using implicit fields like Neural Radiance Fields (NeRF), achieve photorealistic and view-consistent 3D head synthesis. However, these methods face limitations in deformation flexibility and editability, hindering the creation of lifelike and easily modifiable 3D heads. We propose a novel approach that enhances the editability and animation control of 3D head avatars by incorporating 3D Gaussian Splatting (3DGS) as an explicit 3D representation. This method enables easier illumination control and improved editability. Central to our approach is the Editable Gaussian Head (EG-Head) model, which combines a 3D Morphable Model (3DMM) with texture maps, allowing precise expression control and flexible texture editing for accurate animation while preserving identity. To capture complex non-facial geometries like hair, we use an auxiliary set of 3DGS and tri-plane features. Extensive experiments demonstrate that our approach delivers high-quality 3D-aware synthesis with state-of-the-art controllability. Our code and models are available at https://github.com/liguohao96/EGG3D.

Heqi Peng, Yunhong Wang, Ruijie Yang et al.

Adversarial example detection, which can be conveniently applied in many scenarios, is important in the area of adversarial defense. Unfortunately, existing detection methods suffer from poor generalization performance, because their training process usually relies on the examples generated from a single known adversarial attack and there exists a large discrepancy between the training and unseen testing adversarial examples. To address this issue, we propose a novel method, named Adversarial Example Detection via Principal Adversarial Domain Adaptation (AED-PADA). Specifically, our approach identifies the Principal Adversarial Domains (PADs), i.e., a combination of features of the adversarial examples generated by different attacks, which possesses a large portion of the entire adversarial feature space. Subsequently, we pioneer to exploit Multi-source Unsupervised Domain Adaptation in adversarial example detection, with PADs as the source domains. Experimental results demonstrate the superior generalization ability of our proposed AED-PADA. Note that this superiority is particularly achieved in challenging scenarios characterized by employing the minimal magnitude constraint for the perturbations.

Yili He, Yan Zhu, Peiyao Fu et al.

Pre-training on image-text colonoscopy records offers substantial potential for improving endoscopic image analysis, but faces challenges including non-informative background images, complex medical terminology, and ambiguous multi-lesion descriptions. We introduce Endo-CLIP, a novel self-supervised framework that enhances Contrastive Language-Image Pre-training (CLIP) for this domain. Endo-CLIP's three-stage framework--cleansing, attunement, and unification--addresses these challenges by (1) removing background frames, (2) leveraging large language models to extract clinical attributes for fine-grained contrastive learning, and (3) employing patient-level cross-attention to resolve multi-polyp ambiguities. Extensive experiments demonstrate that Endo-CLIP significantly outperforms state-of-the-art pre-training methods in zero-shot and few-shot polyp detection and classification, paving the way for more accurate and clinically relevant endoscopic analysis.