Tulay Adali

Fateme Ghayem, Hanlu Yang, Furkan Kantar et al.

Independent component analysis (ICA) of multi-subject functional magnetic resonance imaging (fMRI) data has proven useful in providing a fully multivariate summary that can be used for multiple purposes. ICA can identify patterns that can discriminate between healthy controls (HC) and patients with various mental disorders such as schizophrenia (Sz). Temporal functional network connectivity (tFNC) obtained from ICA can effectively explain the interactions between brain networks. On the other hand, dictionary learning (DL) enables the discovery of hidden information in data using learnable basis signals through the use of sparsity. In this paper, we present a new method that leverages ICA and DL for the identification of directly interpretable patterns to discriminate between the HC and Sz groups. We use multi-subject resting-state fMRI data from $358$ subjects and form subject-specific tFNC feature vectors from ICA results. Then, we learn sparse representations of the tFNCs and introduce a new set of sparse features as well as new interpretable patterns from the learned atoms. Our experimental results show that the new representation not only leads to effective classification between HC and Sz groups using sparse features, but can also identify new interpretable patterns from the learned atoms that can help understand the complexities of mental diseases such as schizophrenia.

Qiang Li, Shujian Yu, Liang Ma et al.

Blind source separation, particularly through independent component analysis (ICA), is widely utilized across various signal processing domains for disentangling underlying components from observed mixed signals, owing to its fully data-driven nature that minimizes reliance on prior assumptions. However, conventional ICA methods rely on an assumption of linear mixing, limiting their ability to capture complex nonlinear relationships and to maintain robustness in noisy environments. In this work, we present deep deterministic nonlinear independent component analysis (DDICA), a novel deep neural network-based framework designed to address these limitations. DDICA leverages a matrix-based entropy function to directly optimize the independence criterion via stochastic gradient descent, bypassing the need for variational approximations or adversarial schemes. This results in a streamlined training process and improved resilience to noise. We validated the effectiveness and generalizability of DDICA across a range of applications, including simulated signal mixtures, hyperspectral image unmixing, modeling of primary visual receptive fields, and resting-state functional magnetic resonance imaging (fMRI) data analysis. Experimental results demonstrate that DDICA effectively separates independent components with high accuracy across a range of applications. These findings suggest that DDICA offers a robust and versatile solution for blind source separation in diverse signal processing tasks.

Oktay Agcaoglu, Rogers F. Silva, Deniz Alacam et al. · gatech

Different brain imaging modalities offer unique insights into brain function and structure. Combining them enhances our understanding of neural mechanisms. Prior multimodal studies fusing functional MRI (fMRI) and structural MRI (sMRI) have shown the benefits of this approach. Since sMRI lacks temporal data, existing fusion methods often compress fMRI temporal information into summary measures, sacrificing rich temporal dynamics. Motivated by the observation that covarying networks are identified in both sMRI and resting-state fMRI, we developed a novel fusion method, by combining deep learning frameworks, copulas and independent component analysis (ICA), named copula linked parallel ICA (CLiP-ICA). This method estimates independent sources for each modality and links the spatial sources of fMRI and sMRI using a copula-based model for more flexible integration of temporal and spatial data. We tested CLiP-ICA using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Our results showed that CLiP-ICA effectively captures both strongly and weakly linked sMRI and fMRI networks, including the cerebellum, sensorimotor, visual, cognitive control, and default mode networks. It revealed more meaningful components and fewer artifacts, addressing the long-standing issue of optimal model order in ICA. CLiP-ICA also detected complex functional connectivity patterns across stages of cognitive decline, with cognitively normal subjects generally showing higher connectivity in sensorimotor and visual networks compared to patients with Alzheimer, along with patterns suggesting potential compensatory mechanisms.

Rogers F. Silva, Sergey M. Plis, Tulay Adali et al.

In the last two decades, unsupervised latent variable models---blind source separation (BSS) especially---have enjoyed a strong reputation for the interpretable features they produce. Seldom do these models combine the rich diversity of information available in multiple datasets. Multidatasets, on the other hand, yield joint solutions otherwise unavailable in isolation, with a potential for pivotal insights into complex systems. To take advantage of the complex multidimensional subspace structures that capture underlying modes of shared and unique variability across and within datasets, we present a direct, principled approach to multidataset combination. We design a new method called multidataset independent subspace analysis (MISA) that leverages joint information from multiple heterogeneous datasets in a flexible and synergistic fashion. Methodological innovations exploiting the Kotz distribution for subspace modeling in conjunction with a novel combinatorial optimization for evasion of local minima enable MISA to produce a robust generalization of independent component analysis (ICA), independent vector analysis (IVA), and independent subspace analysis (ISA) in a single unified model. We highlight the utility of MISA for multimodal information fusion, including sample-poor regimes and low signal-to-noise ratio scenarios, promoting novel applications in both unimodal and multimodal brain imaging data.

Zois Boukouvalas, Rami Mowakeaa, Geng-Shen Fu et al.

Independent component analysis (ICA) is the most popular method for blind source separation (BSS) with a diverse set of applications, such as biomedical signal processing, video and image analysis, and communications. Maximum likelihood (ML), an optimal theoretical framework for ICA, requires knowledge of the true underlying probability density function (PDF) of the latent sources, which, in many applications, is unknown. ICA algorithms cast in the ML framework often deviate from its theoretical optimality properties due to poor estimation of the source PDF. Therefore, accurate estimation of source PDFs is critical in order to avoid model mismatch and poor ICA performance. In this paper, we propose a new and efficient ICA algorithm based on entropy maximization with kernels, (ICA-EMK), which uses both global and local measuring functions as constraints to dynamically estimate the PDF of the sources with reasonable complexity. In addition, the new algorithm performs optimization with respect to each of the cost function gradient directions separately, enabling parallel implementations on multi-core computers. We demonstrate the superior performance of ICA-EMK over competing ICA algorithms using simulated as well as real-world data.

Zois Boukouvalas, Yuri Levin-Schwartz, Tulay Adali

Independent component analysis (ICA) is a powerful method for blind source separation based on the assumption that sources are statistically independent. Though ICA has proven useful and has been employed in many applications, complete statistical independence can be too restrictive an assumption in practice. Additionally, important prior information about the data, such as sparsity, is usually available. Sparsity is a natural property of the data, a form of diversity, which, if incorporated into the ICA model, can relax the independence assumption, resulting in an improvement in the overall separation performance. In this work, we propose a new variant of ICA by entropy bound minimization (ICA-EBM)-a flexible, yet parameter-free algorithm-through the direct exploitation of sparsity. Using this new SparseICA-EBM algorithm, we study the synergy of independence and sparsity through simulations on synthetic as well as functional magnetic resonance imaging (fMRI)-like data.