Yannis Kopsinis

Youngjoo Seo, Manuel Morante, Yannis Kopsinis et al.

In this paper, we propose a novel unsupervised learning method to learn the brain dynamics using a deep learning architecture named residual D-net. As it is often the case in medical research, in contrast to typical deep learning tasks, the size of the resting-state functional Magnetic Resonance Image (rs-fMRI) datasets for training is limited. Thus, the available data should be very efficiently used to learn the complex patterns underneath the brain connectivity dynamics. To address this issue, we use residual connections to alleviate the training complexity through recurrent multi-scale representation. We conduct two classification tasks to differentiate early and late stage Mild Cognitive Impairment (MCI) from Normal healthy Control (NC) subjects. The experiments verify that our proposed residual D-net indeed learns the brain connectivity dynamics, leading to significantly higher classification accuracy compared to previously published techniques.

Manuel Morante, Yannis Kopsinis, Sergios Theodoridis et al.

In this paper, the task-related fMRI problem is treated in its matrix factorization formulation, focused on the Dictionary Learning (DL) approach. The new method allows the incorporation of a priori knowledge associated both with the experimental design as well as with available brain Atlases. Moreover, the proposed method can efficiently cope with uncertainties related to the HRF modeling. In addition, the proposed method bypasses one of the major drawbacks that are associated with DL methods; that is, the selection of the sparsity-related regularization parameters. In our formulation, an alternative sparsity promoting constraint is employed, that bears a direct relation to the number of voxels in the spatial maps. Hence, the related parameters can be tuned using information that is available from brain atlases. The proposed method is evaluated against several other popular techniques, including GLM. The obtained performance gains are reported via a novel realistic synthetic fMRI dataset as well as real data that are related to a challenging experimental design.

Manuel Morante Moreno, Yannis Kopsinis, Eleftherios Kofidis et al.

Extracting information from functional magnetic resonance (fMRI) images has been a major area of research for more than two decades. The goal of this work is to present a new method for the analysis of fMRI data sets, that is capable to incorporate a priori available information, via an efficient optimization framework. Tests on synthetic data sets demonstrate significant performance gains over existing methods of this kind.