Ugur Demir

Zheyuan Zhang, Bin Wang, Lanhong Yao et al.

Most statistical learning algorithms rely on an over-simplified assumption, that is, the train and test data are independent and identically distributed. In real-world scenarios, however, it is common for models to encounter data from new and different domains to which they were not exposed to during training. This is often the case in medical imaging applications due to differences in acquisition devices, imaging protocols, and patient characteristics. To address this problem, domain generalization (DG) is a promising direction as it enables models to handle data from previously unseen domains by learning domain-invariant features robust to variations across different domains. To this end, we introduce a novel DG method called Adversarial Intensity Attack (AdverIN), which leverages adversarial training to generate training data with an infinite number of styles and increase data diversity while preserving essential content information. We conduct extensive evaluation experiments on various multi-domain segmentation datasets, including 2D retinal fundus optic disc/cup and 3D prostate MRI. Our results demonstrate that AdverIN significantly improves the generalization ability of the segmentation models, achieving significant improvement on these challenging datasets. Code is available upon publication.

Zheyuan Zhang, Bin Wang, Debesh Jha et al.

Domain generalization (DG) approaches intend to extract domain invariant features that can lead to a more robust deep learning model. In this regard, style augmentation is a strong DG method taking advantage of instance-specific feature statistics containing informative style characteristics to synthetic novel domains. While it is one of the state-of-the-art methods, prior works on style augmentation have either disregarded the interdependence amongst distinct feature channels or have solely constrained style augmentation to linear interpolation. To address these research gaps, in this work, we introduce a novel augmentation approach, named Correlated Style Uncertainty (CSU), surpassing the limitations of linear interpolation in style statistic space and simultaneously preserving vital correlation information. Our method's efficacy is established through extensive experimentation on diverse cross-domain computer vision and medical imaging classification tasks: PACS, Office-Home, and Camelyon17 datasets, and the Duke-Market1501 instance retrieval task. The results showcase a remarkable improvement margin over existing state-of-the-art techniques. The source code is available https://github.com/freshman97/CSU.

Ugur Demir, Philipp M. Srivastava, Aggelos Katsaggelos et al.

Binary stellar evolution simulations are computationally expensive. Stellar population synthesis relies on these detailed evolution models at a fundamental level. Producing thousands of such models requires hundreds of CPU hours, but stellar track interpolation provides one approach to significantly reduce this computational cost. Although single-star track interpolation is straightforward, stellar interactions in binary systems introduce significant complexity to binary evolution, making traditional single-track interpolation methods inapplicable. Binary tracks present fundamentally different challenges compared to single stars, which possess relatively straightforward evolutionary phases identifiable through distinct physical properties. Binary systems are complicated by mutual interactions that can dramatically alter evolutionary trajectories and introduce discontinuities difficult to capture through standard interpolation. In this work, we introduce a novel approach for track alignment and iterative track averaging based on Dynamic Time Warping to address misalignments between neighboring tracks. Our method computes a single shared warping path across all physical parameters simultaneously, placing them on a consistent temporal grid that preserves the causal relationships between parameters. We demonstrate that this joint-alignment strategy maintains key physical relationships such as the Stefan-Boltzmann law in the interpolated tracks. Our comprehensive evaluation across multiple binary configurations demonstrates that proper temporal alignment is crucial for track interpolation methods. The proposed method consistently outperforms existing approaches and enables the efficient generation of more accurate binary population samples for astrophysical studies.

Ugur Demir, Zheyuan Zhang, Bin Wang et al.

Automated liver segmentation from radiology scans (CT, MRI) can improve surgery and therapy planning and follow-up assessment in addition to conventional use for diagnosis and prognosis. Although convolutional neural networks (CNNs) have become the standard image segmentation tasks, more recently this has started to change towards Transformers based architectures because Transformers are taking advantage of capturing long range dependence modeling capability in signals, so called attention mechanism. In this study, we propose a new segmentation approach using a hybrid approach combining the Transformer(s) with the Generative Adversarial Network (GAN) approach. The premise behind this choice is that the self-attention mechanism of the Transformers allows the network to aggregate the high dimensional feature and provide global information modeling. This mechanism provides better segmentation performance compared with traditional methods. Furthermore, we encode this generator into the GAN based architecture so that the discriminator network in the GAN can classify the credibility of the generated segmentation masks compared with the real masks coming from human (expert) annotations. This allows us to extract the high dimensional topology information in the mask for biomedical image segmentation and provide more reliable segmentation results. Our model achieved a high dice coefficient of 0.9433, recall of 0.9515, and precision of 0.9376 and outperformed other Transformer based approaches.

Manuel Ballester, Santiago Lopez-Tapia, Seth Gossage et al.

Stellar astrophysics relies critically on accurate descriptions of the physical conditions inside stars. Traditional solvers such as \texttt{MESA} (Modules for Experiments in Stellar Astrophysics), which employ adaptive finite-difference methods, can become computationally expensive and challenging to scale for large stellar population synthesis ($>10^9$ stars). In this work, we present an self-supervised physics-informed neural network (PINN) framework that provides a mesh-free and fully differentiable approach to solving the stellar structure equations under hydrostatic and thermal equilibrium. The model takes as input the stellar boundary conditions (at the center and surface) together with the chemical composition, and learns continuous radial profiles for mass $M_r(r)$, pressure $P(r)$, density $ρ(r)$, temperature $T(r)$, and luminosity $L_r(r)$ by enforcing the governing structure equations through physics-based loss terms. To incorporate realistic microphysics, we introduce auxiliary neural networks that approximate the equation of state and opacity tables as smooth, differentiable functions of the local thermodynamic state. These surrogates replace traditional tabulated inputs and enable end-to-end training. Once trained for a given star, the model produces continuous solutions across the entire radial domain without requiring discretization or interpolation. Validation against benchmark \texttt{MESA} models across a range of stellar masses yields a Mean Relative Absolute Error of $3.06\%$ and an average $R^2$ score of $99.98\%$. To our knowledge, this is the first demonstration that the stellar structure equations can be solved in a fully self-supervised and data-free fashion employing PINNs. This work establishes a foundation for scalable, physics-informed emulation of stellar interiors and opens the door to future extensions toward time-dependent stellar evolution.

Tara M. Pattilachan, Ugur Demir, Elif Keles et al.

Current data augmentation techniques and transformations are well suited for improving the size and quality of natural image datasets but are not yet optimized for medical imaging. We hypothesize that sub-optimal data augmentations can easily distort or occlude medical images, leading to false positives or negatives during patient diagnosis, prediction, or therapy/surgery evaluation. In our experimental results, we found that utilizing commonly used intensity-based data augmentation distorts the MRI scans and leads to texture information loss, thus negatively affecting the overall performance of classification. Additionally, we observed that commonly used data augmentation methods cannot be used with a plug-and-play approach in medical imaging, and requires manual tuning and adjustment.

Lanhong Yao, Zheyuan Zhang, Ugur Demir et al.

Intraductal Papillary Mucinous Neoplasm (IPMN) cysts are pre-malignant pancreas lesions, and they can progress into pancreatic cancer. Therefore, detecting and stratifying their risk level is of ultimate importance for effective treatment planning and disease control. However, this is a highly challenging task because of the diverse and irregular shape, texture, and size of the IPMN cysts as well as the pancreas. In this study, we propose a novel computer-aided diagnosis pipeline for IPMN risk classification from multi-contrast MRI scans. Our proposed analysis framework includes an efficient volumetric self-adapting segmentation strategy for pancreas delineation, followed by a newly designed deep learning-based classification scheme with a radiomics-based predictive approach. We test our proposed decision-fusion model in multi-center data sets of 246 multi-contrast MRI scans and obtain superior performance to the state of the art (SOTA) in this field. Our ablation studies demonstrate the significance of both radiomics and deep learning modules for achieving the new SOTA performance compared to international guidelines and published studies (81.9\% vs 61.3\% in accuracy). Our findings have important implications for clinical decision-making. In a series of rigorous experiments on multi-center data sets (246 MRI scans from five centers), we achieved unprecedented performance (81.9\% accuracy).

Ugur Demir, Debesh Jha, Zheyuan Zhang et al.

Deployments of artificial intelligence in medical diagnostics mandate not just accuracy and efficacy but also trust, emphasizing the need for explainability in machine decisions. The recent trend in automated medical image diagnostics leans towards the deployment of Transformer-based architectures, credited to their impressive capabilities. Since the self-attention feature of transformers contributes towards identifying crucial regions during the classification process, they enhance the trustability of the methods. However, the complex intricacies of these attention mechanisms may fall short of effectively pinpointing the regions of interest directly influencing AI decisions. Our research endeavors to innovate a unique attention block that underscores the correlation between 'regions' rather than 'pixels'. To address this challenge, we introduce an innovative system grounded in prototype learning, featuring an advanced self-attention mechanism that goes beyond conventional ad-hoc visual explanation techniques by offering comprehensible visual insights. A combined quantitative and qualitative methodological approach was used to demonstrate the effectiveness of the proposed method on the large-scale NIH chest X-ray dataset. Experimental results showed that our proposed method offers a promising direction for explainability, which can lead to the development of more trustable systems, which can facilitate easier and rapid adoption of such technology into routine clinics. The code is available at www.github.com/NUBagcilab/r2r_proto.

Ugur Demir, Yogesh S Rawat, Mubarak Shah

The existing research in action recognition is mostly focused on high-quality videos where the action is distinctly visible. In real-world surveillance environments, the actions in videos are captured at a wide range of resolutions. Most activities occur at a distance with a small resolution and recognizing such activities is a challenging problem. In this work, we focus on recognizing tiny actions in videos. We introduce a benchmark dataset, TinyVIRAT, which contains natural low-resolution activities. The actions in TinyVIRAT videos have multiple labels and they are extracted from surveillance videos which makes them realistic and more challenging. We propose a novel method for recognizing tiny actions in videos which utilizes a progressive generative approach to improve the quality of low-resolution actions. The proposed method also consists of a weakly trained attention mechanism which helps in focusing on the activity regions in the video. We perform extensive experiments to benchmark the proposed TinyVIRAT dataset and observe that the proposed method significantly improves the action recognition performance over baselines. We also evaluate the proposed approach on synthetically resized action recognition datasets and achieve state-of-the-art results when compared with existing methods. The dataset and code is publicly available at https://github.com/UgurDemir/Tiny-VIRAT.

Elizabeth Teng, Ugur Demir, Zoheyr Doctor et al.

Knowledge about the internal physical structure of stars is crucial to understanding their evolution. The novel binary population synthesis code POSYDON includes a module for interpolating the stellar and binary properties of any system at the end of binary MESA evolution based on a pre-computed set of models. In this work, we present a new emulation method for predicting stellar profiles, i.e., the internal stellar structure along the radial axis, using machine learning techniques. We use principal component analysis for dimensionality reduction and fully-connected feed-forward neural networks for making predictions. We find accuracy to be comparable to that of nearest neighbor approximation, with a strong advantage in terms of memory and storage efficiency. By providing a versatile framework for modeling stellar internal structure, the emulation method presented here will enable faster simulations of higher physical fidelity, offering a foundation for a wide range of large-scale population studies of stellar and binary evolution.

Fadi Boutros, Naser Damer, Jan Niklas Kolf et al.

This paper presents a summary of the Masked Face Recognition Competitions (MFR) held within the 2021 International Joint Conference on Biometrics (IJCB 2021). The competition attracted a total of 10 participating teams with valid submissions. The affiliations of these teams are diverse and associated with academia and industry in nine different countries. These teams successfully submitted 18 valid solutions. The competition is designed to motivate solutions aiming at enhancing the face recognition accuracy of masked faces. Moreover, the competition considered the deployability of the proposed solutions by taking the compactness of the face recognition models into account. A private dataset representing a collaborative, multi-session, real masked, capture scenario is used to evaluate the submitted solutions. In comparison to one of the top-performing academic face recognition solutions, 10 out of the 18 submitted solutions did score higher masked face verification accuracy.

Ugur Demir, Ismail Irmakci, Elif Keles et al.

Visual explanation methods have an important role in the prognosis of the patients where the annotated data is limited or unavailable. There have been several attempts to use gradient-based attribution methods to localize pathology from medical scans without using segmentation labels. This research direction has been impeded by the lack of robustness and reliability. These methods are highly sensitive to the network parameters. In this study, we introduce a robust visual explanation method to address this problem for medical applications. We provide an innovative visual explanation algorithm for general purpose and as an example application, we demonstrate its effectiveness for quantifying lesions in the lungs caused by the Covid-19 with high accuracy and robustness without using dense segmentation labels. This approach overcomes the drawbacks of commonly used Grad-CAM and its extended versions. The premise behind our proposed strategy is that the information flow is minimized while ensuring the classifier prediction stays similar. Our findings indicate that the bottleneck condition provides a more stable severity estimation than the similar attribution methods.

Mamshad Nayeem Rizve, Ugur Demir, Praveen Tirupattur et al.

Activity detection in security videos is a difficult problem due to multiple factors such as large field of view, presence of multiple activities, varying scales and viewpoints, and its untrimmed nature. The existing research in activity detection is mainly focused on datasets, such as UCF-101, JHMDB, THUMOS, and AVA, which partially address these issues. The requirement of processing the security videos in real-time makes this even more challenging. In this work we propose Gabriella, a real-time online system to perform activity detection on untrimmed security videos. The proposed method consists of three stages: tubelet extraction, activity classification, and online tubelet merging. For tubelet extraction, we propose a localization network which takes a video clip as input and spatio-temporally detects potential foreground regions at multiple scales to generate action tubelets. We propose a novel Patch-Dice loss to handle large variations in actor size. Our online processing of videos at a clip level drastically reduces the computation time in detecting activities. The detected tubelets are assigned activity class scores by the classification network and merged together using our proposed Tubelet-Merge Action-Split (TMAS) algorithm to form the final action detections. The TMAS algorithm efficiently connects the tubelets in an online fashion to generate action detections which are robust against varying length activities. We perform our experiments on the VIRAT and MEVA (Multiview Extended Video with Activities) datasets and demonstrate the effectiveness of the proposed approach in terms of speed (~100 fps) and performance with state-of-the-art results. The code and models will be made publicly available.

Sahin Olut, Yusuf Huseyin Sahin, Ugur Demir et al.

Magnetic Resonance Angiography (MRA) has become an essential MR contrast for imaging and evaluation of vascular anatomy and related diseases. MRA acquisitions are typically ordered for vascular interventions, whereas in typical scenarios, MRA sequences can be absent in the patient scans. This motivates the need for a technique that generates inexistent MRA from existing MR multi-contrast, which could be a valuable tool in retrospective subject evaluations and imaging studies. In this paper, we present a generative adversarial network (GAN) based technique to generate MRA from T1-weighted and T2-weighted MRI images, for the first time to our knowledge. To better model the representation of vessels which the MRA inherently highlights, we design a loss term dedicated to a faithful reproduction of vascularities. To that end, we incorporate steerable filter responses of the generated and reference images inside a Huber function loss term. Extending the well- established generator-discriminator architecture based on the recent PatchGAN model with the addition of steerable filter loss, the proposed steerable GAN (sGAN) method is evaluated on the large public database IXI. Experimental results show that the sGAN outperforms the baseline GAN method in terms of an overlap score with similar PSNR values, while it leads to improved visual perceptual quality.

Ugur Demir, Gozde Unal

Area of image inpainting over relatively large missing regions recently advanced substantially through adaptation of dedicated deep neural networks. However, current network solutions still introduce undesired artifacts and noise to the repaired regions. We present an image inpainting method that is based on the celebrated generative adversarial network (GAN) framework. The proposed PGGAN method includes a discriminator network that combines a global GAN (G-GAN) architecture with a patchGAN approach. PGGAN first shares network layers between G-GAN and patchGAN, then splits paths to produce two adversarial losses that feed the generator network in order to capture both local continuity of image texture and pervasive global features in images. The proposed framework is evaluated extensively, and the results including comparison to recent state-of-the-art demonstrate that it achieves considerable improvements on both visual and quantitative evaluations.

Ugur Demir, Gozde Unal

Deep neural networks have shown promising results in image inpainting even if the missing area is relatively large. However, most of the existing inpainting networks introduce undesired artifacts and noise to the repaired regions. To solve this problem, we present a novel framework which consists of two stacked convolutional neural networks that inpaint the image and remove the artifacts, respectively. The first network considers the global structure of the damaged image and coarsely fills the blank area. Then the second network modifies the repaired image to cancel the noise introduced by the first network. The proposed framework splits the problem into two distinct partitions that can be optimized separately, therefore it can be applied to any inpainting algorithm by changing the first network. Second stage in our framework which aims at polishing the inpainted images can be treated as a denoising problem where a wide range of algorithms can be employed. Our results demonstrate that the proposed framework achieves significant improvement on both visual and quantitative evaluations.