Haotian Lu

Nianzu Yang, Kaipeng Zeng, Haotian Lu et al.

Neuronal morphology is essential for studying brain functioning and understanding neurodegenerative disorders. As acquiring real-world morphology data is expensive, computational approaches for morphology generation have been studied. Traditional methods heavily rely on expert-set rules and parameter tuning, making it difficult to generalize across different types of morphologies. Recently, MorphVAE was introduced as the sole learning-based method, but its generated morphologies lack plausibility, i.e., they do not appear realistic enough and most of the generated samples are topologically invalid. To fill this gap, this paper proposes MorphGrower, which mimicks the neuron natural growth mechanism for generation. Specifically, MorphGrower generates morphologies layer by layer, with each subsequent layer conditioned on the previously generated structure. During each layer generation, MorphGrower utilizes a pair of sibling branches as the basic generation block and generates branch pairs synchronously. This approach ensures topological validity and allows for fine-grained generation, thereby enhancing the realism of the final generated morphologies. Results on four real-world datasets demonstrate that MorphGrower outperforms MorphVAE by a notable margin. Importantly, the electrophysiological response simulation demonstrates the plausibility of our generated samples from a neuroscience perspective. Our code is available at https://github.com/Thinklab-SJTU/MorphGrower.

Fangwei Hao, Jiesheng Wu, Haotian Lu et al.

The multi-scale receptive field and large kernel attention (LKA) module have been shown to significantly improve performance in the lightweight image super-resolution task. However, existing lightweight super-resolution (SR) methods seldom pay attention to designing efficient building block with multi-scale receptive field for local modeling, and their LKA modules face a quadratic increase in computational and memory footprints as the convolutional kernel size increases. To address the first issue, we propose the multi-scale blueprint separable convolutions (MBSConv) as highly efficient building block with multi-scale receptive field, it can focus on the learning for the multi-scale information which is a vital component of discriminative representation. As for the second issue, we revisit the key properties of LKA in which we find that the adjacent direct interaction of local information and long-distance dependencies is crucial to provide remarkable performance. Thus, taking this into account and in order to mitigate the complexity of LKA, we propose a large coordinate kernel attention (LCKA) module which decomposes the 2D convolutional kernels of the depth-wise convolutional layers in LKA into horizontal and vertical 1-D kernels. LCKA enables the adjacent direct interaction of local information and long-distance dependencies not only in the horizontal direction but also in the vertical. Besides, LCKA allows for the direct use of extremely large kernels in the depth-wise convolutional layers to capture more contextual information, which helps to significantly improve the reconstruction performance, and it incurs lower computational complexity and memory footprints. Integrating MBSConv and LCKA, we propose a large coordinate kernel attention network (LCAN).