Indu Bala

Subarna Khanra, Vijay Kumar Kukreja, Indu Bala

Demographic forecasting remains a fundamental challenge for policy planning in rapidly evolving nations such as India, where fertility transitions, policy interventions, and age structured dynamics interact in complex ways. In this study, we present a hybrid modelling framework that integrates policy-aware fertility functions into a Physics-Informed Neural Network (PINN) enhanced with Long Short-Term Memory (LSTM) networks to capture physical constraints and temporal dependencies in population dynamics. The model is applied to India's age structured population from 2024 to 2054 under three fertility-policy scenarios: continuation of current fertility decline, stricter population control, and relaxed fertility promotion. The governing transport-reaction partial differential equation is formulated with India-specific demographic indicators, including age-specific fertility and mortality rates. PINNs embed the core population equation and policy-driven fertility changes, while LSTM layers improve long-term forecasting across decades. Results show that fertility policies substantially shape future age distribution, dependency ratios, and workforce size. Stricter controls intensify ageing and reduce labour force participation, whereas relaxed policies support workforce growth but increase population pressure. Our findings suggest that the hybrid LSTM-PINN is an effective approach for demographic forecasting, offering accuracy with interpretability. Beyond methodological novelty, this work provides actionable insights for India's demographic policy debates, highlighting the need for balanced fertility interventions to ensure sustainable socio-economic development.

Dikshit Chauhan, Bapi Dutta, Indu Bala et al.

Integrating Large Language Models (LLMs) and Evolutionary Computation (EC) represents a promising avenue for advancing artificial intelligence by combining powerful natural language understanding with optimization and search capabilities. This manuscript explores the synergistic potential of LLMs and EC, reviewing their intersections, complementary strengths, and emerging applications. We identify key opportunities where EC can enhance LLM training, fine-tuning, prompt engineering, and architecture search, while LLMs can, in turn, aid in automating the design, analysis, and interpretation of ECs. The manuscript explores the synergistic integration of EC and LLMs, highlighting their bidirectional contributions to advancing artificial intelligence. It first examines how EC techniques enhance LLMs by optimizing key components such as prompt engineering, hyperparameter tuning, and architecture search, demonstrating how evolutionary methods automate and refine these processes. Secondly, the survey investigates how LLMs improve EC by automating metaheuristic design, tuning evolutionary algorithms, and generating adaptive heuristics, thereby increasing efficiency and scalability. Emerging co-evolutionary frameworks are discussed, showcasing applications across diverse fields while acknowledging challenges like computational costs, interpretability, and algorithmic convergence. The survey concludes by identifying open research questions and advocating for hybrid approaches that combine the strengths of EC and LLMs.

Nitin Gupta, Indu Bala, Bapi Dutta et al.

Swarm intelligence effectively optimizes complex systems across fields like engineering and healthcare, yet algorithm solutions often suffer from low reliability due to unclear configurations and hyperparameters. This study analyzes Particle Swarm Optimization (PSO), focusing on how different communication topologies Ring, Star, and Von Neumann affect convergence and search behaviors. Using an adapted IOHxplainer , an explainable benchmarking tool, we investigate how these topologies influence information flow, diversity, and convergence speed, clarifying the balance between exploration and exploitation. Through visualization and statistical analysis, the research enhances interpretability of PSO's decisions and provides practical guidelines for choosing suitable topologies for specific optimization tasks. Ultimately, this contributes to making swarm based optimization more transparent, robust, and trustworthy.

Siying Liu, Shisheng Zhang, Indu Bala

Large language models (LLMs) are increasingly applied in biomedical domains, yet their reliability in drug-safety prediction remains underexplored. In this work, we investigate whether LLMs incorporate socio-demographic information into adverse event (AE) predictions, despite such attributes being clinically irrelevant. Using structured data from the United States Food and Drug Administration Adverse Event Reporting System (FAERS) and a persona-based evaluation framework, we assess two state-of-the-art models, ChatGPT-4o and Bio-Medical-Llama-3.8B, across diverse personas defined by education, marital status, employment, insurance, language, housing stability, and religion. We further evaluate performance across three user roles (general practitioner, specialist, patient) to reflect real-world deployment scenarios where commercial systems often differentiate access by user type. Our results reveal systematic disparities in AE prediction accuracy. Disadvantaged groups (e.g., low education, unstable housing) were frequently assigned higher predicted AE likelihoods than more privileged groups (e.g., postgraduate-educated, privately insured). Beyond outcome disparities, we identify two distinct modes of bias: explicit bias, where incorrect predictions directly reference persona attributes in reasoning traces, and implicit bias, where predictions are inconsistent, yet personas are not explicitly mentioned. These findings expose critical risks in applying LLMs to pharmacovigilance and highlight the urgent need for fairness-aware evaluation protocols and mitigation strategies before clinical deployment.

Indu Bala, Lewis Mitchell, Marianne H Gillam

Mesh implants are widely utilized in hernia repair surgeries, but postoperative complications present a significant concern. This study analyzes patient reports from the Manufacturer and User Facility Device Experience (MAUDE) database spanning 2000 to 2021 to investigate the emotional aspects of patients following mesh implantation using Natural Language Processing (NLP). Employing the National Research Council Canada (NRC) Emotion Lexicon and TextBlob for sentiment analysis, the research categorizes patient narratives into eight emotions (anger, fear, anticipation, trust, surprise, sadness, joy, and disgust) and assesses sentiment polarity. The goal is to discern patterns in patient sentiment over time and to identify reports signaling urgent concerns, referred to as "Concern Reports," thereby understanding shifts in patient experiences in relation to changes in medical device regulation and technological advancements in healthcare. The study detected an increase in Concern Reports and higher emotional intensity during the periods of 2011-2012 and 2017-2018. Through temporal analysis of Concern Reports and overall sentiment, this research provides valuable insights for healthcare practitioners, enhancing their understanding of patient experiences post-surgery, which is critical for improving preoperative counselling, postoperative care, and preparing patients for mesh implant surgeries. The study underscores the importance of emotional considerations in medical practices and the potential for sentiment analysis to inform and enhance patient care.