Xiaoqiao Chen

Xiaoqiao Chen

Short-term industrial enterprises power system forecasting is an important issue for both load control and machine protection. Scientists focus on load forecasting but ignore other valuable electric-meters which should provide guidance of power system protection. We propose a new framework, multi-variable adversarial time-series forecasting model, which regularizes Long Short-term Memory (LSTM) models via an adversarial process. The novel model forecasts all variables (may in different type, such as continue variables, category variables, etc.) in power system at the same time and helps trade-off process between forecasting accuracy of single variable and variable-variable relations. Experiments demonstrate the potential of the framework through qualitative and quantitative evaluation of the generated samples. The predict results of electricity consumption of industrial enterprises by multi-variable adversarial time-series forecasting model show that the proposed approach is able to achieve better prediction accuracy. We also applied this model to real industrial enterprises power system data we gathered from several large industrial enterprises via advanced power monitors, and got impressed forecasting results.

Xiaoqiao Chen, Sisi Chen, Matt Thomson

Sequencing costs currently prohibit the application of single-cell mRNA-seq to many biological and clinical analyses. Targeted single-cell mRNA-sequencing reduces sequencing costs by profiling reduced gene sets that capture biological information with a minimal number of genes. Here, we introduce an active learning method (ActiveSVM) that identifies minimal but highly-informative gene sets that enable the identification of cell-types, physiological states, and genetic perturbations in single-cell data using a small number of genes. Our active feature selection procedure generates minimal gene sets from single-cell data through an iterative cell-type classification task where misclassified cells are examined at each round of analysis to identify maximally informative genes through an `active' support vector machine (ActiveSVM) classifier. By focusing computational resources on misclassified cells, ActiveSVM scales to analyze data sets with over a million single cells. We demonstrate that ActiveSVM feature selection identifies gene sets that enable ~90% cell-type classification accuracy across a variety of data sets including cell atlas and disease characterization data sets. The method generalizes to reveal genes that respond to genetic perturbations and to identify region specific gene expression patterns in spatial transcriptomics data. The discovery of small but highly informative gene sets should enable substantial reductions in the number of measurements necessary for application of single-cell mRNA-seq to clinical tests, therapeutic discovery, and genetic screens.