Zhiyuan Yan

Shanzhuo Zhang, Zhiyuan Yan, Yueyang Huang et al.

Accurate ADMET (an abbreviation for "absorption, distribution, metabolism, excretion, and toxicity") predictions can efficiently screen out undesirable drug candidates in the early stage of drug discovery. In recent years, multiple comprehensive ADMET systems that adopt advanced machine learning models have been developed, providing services to estimate multiple endpoints. However, those ADMET systems usually suffer from weak extrapolation ability. First, due to the lack of labelled data for each endpoint, typical machine learning models perform frail for the molecules with unobserved scaffolds. Second, most systems only provide fixed built-in endpoints and cannot be customised to satisfy various research requirements. To this end, we develop a robust and endpoint extensible ADMET system, HelixADMET (H-ADMET). H-ADMET incorporates the concept of self-supervised learning to produce a robust pre-trained model. The model is then fine-tuned with a multi-task and multi-stage framework to transfer knowledge between ADMET endpoints, auxiliary tasks, and self-supervised tasks. Our results demonstrate that H-ADMET achieves an overall improvement of 4%, compared with existing ADMET systems on comparable endpoints. Additionally, the pre-trained model provided by H-ADMET can be fine-tuned to generate new and customised ADMET endpoints, meeting various demands of drug research and development requirements.

Zhiyuan Yan, Junyan Ye, Weijia Li et al.

The recent breakthroughs in OpenAI's GPT4o model have demonstrated surprisingly good capabilities in image generation and editing, resulting in significant excitement in the community. This technical report presents the first-look evaluation benchmark (named GPT-ImgEval), quantitatively and qualitatively diagnosing GPT-4o's performance across three critical dimensions: (1) generation quality, (2) editing proficiency, and (3) world knowledge-informed semantic synthesis. Across all three tasks, GPT-4o demonstrates strong performance, significantly surpassing existing methods in both image generation control and output quality, while also showcasing exceptional knowledge reasoning capabilities. Furthermore, based on the GPT-4o's generated data, we propose a classification-model-based approach to investigate the underlying architecture of GPT-4o, where our empirical results suggest the model consists of an auto-regressive (AR) combined with a diffusion-based head for image decoding, rather than the VAR-like architectures. We also provide a complete speculation on GPT-4o's overall architecture. In addition, we conduct a series of analyses to identify and visualize GPT-4o's specific limitations and the synthetic artifacts commonly observed in its image generation. We also present a comparative study of multi-round image editing between GPT-4o and Gemini 2.0 Flash, and discuss the safety implications of GPT-4o's outputs, particularly their detectability by existing image forensic models. We hope that our work can offer valuable insight and provide a reliable benchmark to guide future research, foster reproducibility, and accelerate innovation in the field of image generation and beyond. The codes and datasets used for evaluating GPT-4o can be found at https://github.com/PicoTrex/GPT-ImgEval.

Junyan Ye, Dongzhi Jiang, Jun He et al.

Recently, Multimodal Large Language Models (MLLMs) have made rapid progress, particularly in enhancing their reasoning capabilities. However, existing reasoning benchmarks still primarily assess language-based reasoning, often treating visual input as replaceable context. To address this gap, we introduce BLINK-Twice, a vision-centric reasoning benchmark grounded in challenging perceptual tasks. Instead of relying on external knowledge, our tasks require models to reason from visual content alone, shifting the focus from language-based to image-grounded reasoning. Compared to prior perception benchmarks, it moves beyond shallow perception ("see") and requires fine-grained observation and analytical reasoning ("observe"). BLINK-Twice integrates three core components: seven types of visual challenges for testing visual reasoning, natural adversarial image pairs that enforce reliance on visual content, and annotated reasoning chains for fine-grained evaluation of the reasoning process rather than final answers alone. We evaluate 20 leading MLLMs, including 12 foundation models and 8 reasoning-enhanced models. BLINK-Twice poses a significant challenge to current models. While existing reasoning strategies in the language space-such as chain-of-thought or self-criticism can improve performance, they often result in unstable and redundant reasoning. We observe that repeated image observation improves performance across models, and active visual interaction, as demonstrated by models like o3, highlights the need for a new paradigm for vision reasoning. The dataset is publicly available at https://github.com/PicoTrex/BLINK-Twice

Zongjian Li, Zheyuan Liu, Qihui Zhang et al.

Instruction-based image editing has achieved remarkable progress; however, models solely trained via supervised fine-tuning often overfit to annotated patterns, hindering their ability to explore and generalize beyond training distributions. To this end, we introduce Edit-R1, a novel post-training framework for instruction-based image editing based on policy optimization. Specifically, we utilize Diffusion Negative-aware Finetuning (DiffusionNFT), a likelihood-free policy optimization method consistent with the flow matching forward process, thereby enabling the use of higher-order samplers and more efficient training. Another key challenge here is the absence of a universal reward model, resulting from the diverse nature of editing instructions and tasks. To bridge this gap, we employ a Multimodal Large Language Model (MLLM) as a unified, training-free reward model, leveraging its output logits to provide fine-grained feedback. Furthermore, we carefully design a low-variance group filtering mechanism to reduce MLLM scoring noise and stabilize optimization. \texttt{UniWorld-V2}, trained with this framework, achieves \textbf{state-of-the-art} results on the ImgEdit and GEdit-Bench benchmarks, scoring 4.49 and 7.83, respectively. Crucially, our framework is model-agnostic, delivering substantial performance gains when applied to diverse base models like Qwen-Image-Edit and FLUX-Kontext, demonstrating its wide applicability. Code and models are publicly available to support further research.

Yuxuan Du, Zhendong Wang, Yuhao Luo et al.

The rapid emergence of multimodal deepfakes (visual and auditory content are manipulated in concert) undermines the reliability of existing detectors that rely solely on modality-specific artifacts or cross-modal inconsistencies. In this work, we first demonstrate that modality-specific forensic traces (e.g., face-swap artifacts or spectral distortions) and modality-shared semantic misalignments (e.g., lip-speech asynchrony) offer complementary evidence, and that neglecting either aspect limits detection performance. Existing approaches either naively fuse modality-specific features without reconciling their conflicting characteristics or focus predominantly on semantic misalignment at the expense of modality-specific fine-grained artifact cues. To address these shortcomings, we propose a general multimodal framework for video deepfake detection via Cross-Modal Alignment and Distillation (CAD). CAD comprises two core components: 1) Cross-modal alignment that identifies inconsistencies in high-level semantic synchronization (e.g., lip-speech mismatches); 2) Cross-modal distillation that mitigates feature conflicts during fusion while preserving modality-specific forensic traces (e.g., spectral distortions in synthetic audio). Extensive experiments on both multimodal and unimodal (e.g., image-only/video-only)deepfake benchmarks demonstrate that CAD significantly outperforms previous methods, validating the necessity of harmonious integration of multimodal complementary information.

Mengyu Wang, Hanbo Bi, Yingchao Feng et al.

Vision foundation models in remote sensing have been extensively studied due to their superior generalization on various downstream tasks. Synthetic Aperture Radar (SAR) offers all-day, all-weather imaging capabilities, providing significant advantages for Earth observation. However, establishing a foundation model for SAR image interpretation inevitably encounters the challenges of insufficient information utilization and poor interpretability. In this paper, we propose a remote sensing foundation model based on complex-valued SAR data, which simulates the polarimetric decomposition process for pre-training, i.e., characterizing pixel scattering intensity as a weighted combination of scattering bases and scattering coefficients, thereby endowing the foundation model with physical interpretability. Specifically, we construct a series of scattering queries, each representing an independent and meaningful scattering basis, which interact with SAR features in the scattering query decoder and output the corresponding scattering coefficient. To guide the pre-training process, polarimetric decomposition loss and power self-supervision loss are constructed. The former aligns the predicted coefficients with Yamaguchi coefficients, while the latter reconstructs power from the predicted coefficients and compares it to the input image's power. The performance of our foundation model is validated on six typical downstream tasks, achieving state-of-the-art results. Notably, the foundation model can extract stable feature representations and exhibits strong generalization, even in data-scarce conditions.