Chia-Ling Tsai

Jiaqi Yang, Nitish Mehta, Xiaoling Hu et al.

Accurate segmentation of Optical Coherence Tomography (OCT) images is crucial for diagnosing and monitoring retinal diseases. However, the labor-intensive nature of pixel-level annotation limits the scalability of supervised learning with large datasets. Weakly Supervised Semantic Segmentation (WSSS) provides a promising alternative by leveraging image-level labels. In this study, we propose a novel WSSS approach that integrates structural guidance with text-driven strategies to generate high-quality pseudo labels, significantly improving segmentation performance. In terms of visual information, our method employs two processing modules that exchange raw image features and structural features from OCT images, guiding the model to identify where lesions are likely to occur. In terms of textual information, we utilize large-scale pretrained models from cross-domain sources to implement label-informed textual guidance and synthetic descriptive integration with two textual processing modules that combine local semantic features with consistent synthetic descriptions. By fusing these visual and textual components within a multimodal framework, our approach enhances lesion localization accuracy. Experimental results on three OCT datasets demonstrate that our method achieves state-of-the-art performance, highlighting its potential to improve diagnostic accuracy and efficiency in medical imaging.

Gozde Merve Demirci, Jiachen Yao, Ming-Chih Ho et al.

Accurate segmentation of retinal images plays a crucial role in aiding ophthalmologists in diagnosing retinopathy of prematurity (ROP) and assessing its severity. However, due to their underdeveloped, thinner vessels, manual annotation in infant fundus images is very complex, and this presents challenges for fully supervised learning. To address the scarcity of annotations, we propose a semi supervised segmentation framework designed to advance ROP studies without the need for extensive manual vessel annotation. Unlike previous methods that rely solely on limited labeled data, our approach leverages teacher student learning by integrating two powerful components: an uncertainty weighted vessel unveiling module and domain adversarial learning. The vessel unveiling module helps the model effectively reveal obscured and hard to detect vessel structures, while adversarial training aligns feature representations across different domains, ensuring robust and generalizable vessel segmentations. We validate our approach on public datasets (CHASEDB, STARE) and an in-house ROP dataset, demonstrating its superior performance across multiple evaluation metrics. Additionally, we extend the model's utility to a downstream task of ROP multi-stage classification, where vessel masks extracted by our segmentation model improve diagnostic accuracy. The promising results in classification underscore the model's potential for clinical application, particularly in early-stage ROP diagnosis and intervention. Overall, our work offers a scalable solution for leveraging unlabeled data in pediatric ophthalmology, opening new avenues for biomarker discovery and clinical research.

Jiaqi Yang, Xiaoling Hu, Chao Chen et al.

Structural accuracy of segmentation is important for finescale structures in biomedical images. We propose a novel TopologyAttention ConvLSTM Network (TACNet) for 3D image segmentation in order to achieve high structural accuracy for 3D segmentation tasks. Specifically, we propose a Spatial Topology-Attention (STA) module to process a 3D image as a stack of 2D image slices and adopt ConvLSTM to leverage contextual structure information from adjacent slices. In order to effectively transfer topology-critical information across slices, we propose an Iterative-Topology Attention (ITA) module that provides a more stable topology-critical map for segmentation. Quantitative and qualitative results show that our proposed method outperforms various baselines in terms of topology-aware evaluation metrics.