Philipp Rostalski

Alexander Bigalke, Lasse Hansen, Jasper Diesel et al.

3D human pose estimation is a key component of clinical monitoring systems. The clinical applicability of deep pose estimation models, however, is limited by their poor generalization under domain shifts along with their need for sufficient labeled training data. As a remedy, we present a novel domain adaptation method, adapting a model from a labeled source to a shifted unlabeled target domain. Our method comprises two complementary adaptation strategies based on prior knowledge about human anatomy. First, we guide the learning process in the target domain by constraining predictions to the space of anatomically plausible poses. To this end, we embed the prior knowledge into an anatomical loss function that penalizes asymmetric limb lengths, implausible bone lengths, and implausible joint angles. Second, we propose to filter pseudo labels for self-training according to their anatomical plausibility and incorporate the concept into the Mean Teacher paradigm. We unify both strategies in a point cloud-based framework applicable to unsupervised and source-free domain adaptation. Evaluation is performed for in-bed pose estimation under two adaptation scenarios, using the public SLP dataset and a newly created dataset. Our method consistently outperforms various state-of-the-art domain adaptation methods, surpasses the baseline model by 31%/66%, and reduces the domain gap by 65%/82%. Source code is available at https://github.com/multimodallearning/da-3dhpe-anatomy.

Malte Luttermann, Edgar Baake, Juljan Bouchagiar et al.

Failure mode and effects analysis (FMEA) is a systematic approach to identify and analyse potential failures and their effects in a system or process. The FMEA approach, however, requires domain experts to manually analyse the FMEA model to derive risk-reducing actions that should be applied. In this paper, we provide a formal framework to allow for automatic planning and acting in FMEA models. More specifically, we cast the FMEA model into a Markov decision process which can then be solved by existing solvers. We show that the FMEA approach can not only be used to support medical experts during the modelling process but also to automatically derive optimal therapies for the treatment of patients.

Eike Petersen, Yannik Potdevin, Esfandiar Mohammadi et al.

Machine learning is expected to fuel significant improvements in medical care. To ensure that fundamental principles such as beneficence, respect for human autonomy, prevention of harm, justice, privacy, and transparency are respected, medical machine learning systems must be developed responsibly. Many high-level declarations of ethical principles have been put forth for this purpose, but there is a severe lack of technical guidelines explicating the practical consequences for medical machine learning. Similarly, there is currently considerable uncertainty regarding the exact regulatory requirements placed upon medical machine learning systems. This survey provides an overview of the technical and procedural challenges involved in creating medical machine learning systems responsibly and in conformity with existing regulations, as well as possible solutions to address these challenges. First, a brief review of existing regulations affecting medical machine learning is provided, showing that properties such as safety, robustness, reliability, privacy, security, transparency, explainability, and nondiscrimination are all demanded already by existing law and regulations - albeit, in many cases, to an uncertain degree. Next, the key technical obstacles to achieving these desirable properties are discussed, as well as important techniques to overcome these obstacles in the medical context. We notice that distribution shift, spurious correlations, model underspecification, uncertainty quantification, and data scarcity represent severe challenges in the medical context. Promising solution approaches include the use of large and representative datasets and federated learning as a means to that end, the careful exploitation of domain knowledge, the use of inherently transparent models, comprehensive out-of-distribution model testing and verification, as well as algorithmic impact assessments.

Jan Graßhoff, Alexandra Jankowski, Philipp Rostalski

The application of Gaussian processes (GPs) to large data sets is limited due to heavy memory and computational requirements. A variety of methods has been proposed to enable scalability, one of which is to exploit structure in the kernel matrix. Previous methods, however, cannot easily deal with non-stationary processes. This paper presents an efficient GP framework, that extends structured kernel interpolation methods to GPs with a non-stationary phase. We particularly treat mixtures of non-stationary processes, which are commonly used in the context of separation problems e.g. in biomedical signal processing. Our approach employs multiple sets of non-equidistant inducing points to account for the non-stationarity and retrieve Toeplitz and Kronecker structure in the kernel matrix allowing for efficient inference. Kernel learning is done by optimizing the marginal likelihood, which can be approximated efficiently using stochastic trace estimation methods. Our approach is demonstrated on numerical examples and large biomedical datasets.