Hongchao Zhou

Hongchao Zhou

Despite its great success, backpropagation has certain limitations that necessitate the investigation of new learning methods. In this study, we present a biologically plausible local learning rule that improves upon Hebb's well-known proposal and discovers unsupervised features by local competitions among neurons. This simple learning rule enables the creation of a forward learning paradigm called activation learning, in which the output activation (sum of the squared output) of the neural network estimates the likelihood of the input patterns, or "learn more, activate more" in simpler terms. For classification on a few small classical datasets, activation learning performs comparably to backpropagation using a fully connected network, and outperforms backpropagation when there are fewer training samples or unpredictable disturbances. Additionally, the same trained network can be used for a variety of tasks, including image generation and completion. Activation learning also achieves state-of-the-art performance on several real-world datasets for anomaly detection. This new learning paradigm, which has the potential to unify supervised, unsupervised, and semi-supervised learning and is reasonably more resistant to adversarial attacks, deserves in-depth investigation.

Junyu Chen, Shuwen Wei, Joel Honkamaa et al.

Medical image challenges have played a transformative role in advancing the field, catalyzing algorithmic innovation and establishing new performance standards across diverse clinical applications. Image registration, a foundational task in neuroimaging pipelines, has similarly benefited from the Learn2Reg initiative. Building on this foundation, we introduce the Large-scale Unsupervised Brain MRI Image Registration (LUMIR) challenge, a next-generation benchmark designed to assess and advance unsupervised brain MRI registration. Distinct from prior challenges that leveraged anatomical label maps for supervision, LUMIR removes this dependency by providing over 4,000 preprocessed T1-weighted brain MRIs for training without any label maps, encouraging biologically plausible deformation modeling through self-supervision. In addition to evaluating performance on 590 held-out test subjects, LUMIR introduces a rigorous suite of zero-shot generalization tasks, spanning out-of-domain imaging modalities (e.g., FLAIR, T2-weighted, T2*-weighted), disease populations (e.g., Alzheimer's disease), acquisition protocols (e.g., 9.4T MRI), and species (e.g., macaque brains). A total of 1,158 subjects and over 4,000 image pairs were included for evaluation. Performance was assessed using both segmentation-based metrics (Dice coefficient, 95th percentile Hausdorff distance) and landmark-based registration accuracy (target registration error). Across both in-domain and zero-shot tasks, deep learning-based methods consistently achieved state-of-the-art accuracy while producing anatomically plausible deformation fields. The top-performing deep learning-based models demonstrated diffeomorphic properties and inverse consistency, outperforming several leading optimization-based methods, and showing strong robustness to most domain shifts, the exception being a drop in performance on out-of-domain contrasts.

Lasse Hansen, Wiebke Heyer, Christoph Großbröhmer et al.

Medical image registration is critical for clinical applications, and fair benchmarking of different methods is essential for monitoring ongoing progress. To date, the Learn2Reg 2020-2023 challenges have released several complementary datasets and established metrics for evaluations. However, these editions did not capture all aspects of the registration problem, particularly in terms of modality diversity and task complexity. To address these limitations, the 2024 edition introduces three new tasks, including large-scale multi-modal registration and unsupervised inter-subject brain registration, as well as the first microscopy-focused benchmark within Learn2Reg. The new datasets also inspired new method developments, including invertibility constraints, pyramid features, keypoints alignment and instance optimisation.

Hongchao Zhou, Jehoshua Bruck

We study the problem of extracting a prescribed number of random bits by reading the smallest possible number of symbols from non-ideal stochastic processes. The related interval algorithm proposed by Han and Hoshi has asymptotically optimal performance; however, it assumes that the distribution of the input stochastic process is known. The motivation for our work is the fact that, in practice, sources of randomness have inherent correlations and are affected by measurement's noise. Namely, it is hard to obtain an accurate estimation of the distribution. This challenge was addressed by the concepts of seeded and seedless extractors that can handle general random sources with unknown distributions. However, known seeded and seedless extractors provide extraction efficiencies that are substantially smaller than Shannon's entropy limit. Our main contribution is the design of extractors that have a variable input-length and a fixed output length, are efficient in the consumption of symbols from the source, are capable of generating random bits from general stochastic processes and approach the information theoretic upper bound on efficiency.

Hongchao Zhou, Jehoshua Bruck

Information-efficient approaches for extracting randomness from imperfect sources have been extensively studied, but simpler and faster ones are required in the high-speed applications of random number generation. In this paper, we focus on linear constructions, namely, applying linear transformation for randomness extraction. We show that linear transformations based on sparse random matrices are asymptotically optimal to extract randomness from independent sources and bit-fixing sources, and they are efficient (may not be optimal) to extract randomness from hidden Markov sources. Further study demonstrates the flexibility of such constructions on source models as well as their excellent information-preserving capabilities. Since linear transformations based on sparse random matrices are computationally fast and can be easy to implement using hardware like FPGAs, they are very attractive in the high-speed applications. In addition, we explore explicit constructions of transformation matrices. We show that the generator matrices of primitive BCH codes are good choices, but linear transformations based on such matrices require more computational time due to their high densities.