V. Tiwari

Vivek Kumar Tiwari, Premananda Indic, Shawana Tabassum

Early diagnosis of Alzheimer's disease is a challenge because the existing methodologies do not identify the patients in their preclinical stage, which can last up to a decade prior to the onset of clinical symptoms. Several research studies demonstrate the potential of cerebrospinal fluid biomarkers, amyloid beta 1-42, T-tau, and P-tau, in early diagnosis of Alzheimer's disease stages. In this work, we used machine learning models to classify different stages of Alzheimer's disease based on the cerebrospinal fluid biomarker levels alone. An electronic health record of patients from the National Alzheimer's Coordinating Centre database was analyzed and the patients were subdivided based on mini-mental state scores and clinical dementia ratings. Statistical and correlation analyses were performed to identify significant differences between the Alzheimer's stages. Afterward, machine learning classifiers including K-Nearest Neighbors, Ensemble Boosted Tree, Ensemble Bagged Tree, Support Vector Machine, Logistic Regression, and Naive Bayes classifiers were employed to classify the Alzheimer's disease stages. The results demonstrate that Ensemble Boosted Tree (84.4%) and Logistic Regression (73.4%) provide the highest accuracy for binary classification, while Ensemble Bagged Tree (75.4%) demonstrates better accuracy for multiclassification. The findings from this research are expected to help clinicians in making an informed decision regarding the early diagnosis of Alzheimer's from the cerebrospinal fluid biomarkers alone, monitoring of the disease progression, and implementation of appropriate intervention measures.

Madhu Kiran, Vivek Tiwari, Le Thanh Nguyen-Meidine et al.

Visual object tracking is an important function in many real-time video surveillance applications, such as localization and spatio-temporal recognition of persons. In real-world applications, an object detector and tracker must interact on a periodic basis to discover new objects, and thereby to initiate tracks. Periodic interactions with the detector can also allow the tracker to validate and/or update its object template with new bounding boxes. However, bounding boxes provided by a state-of-the-art detector are noisy, due to changes in appearance, background and occlusion, which can cause the tracker to drift. Moreover, CNN-based detectors can provide a high level of accuracy at the expense of computational complexity, so interactions should be minimized for real-time applications. In this paper, a new approach is proposed to manage detector-tracker interactions for trackers from the Siamese-FC family. By integrating a change detection mechanism into a deep Siamese-FC tracker, its template can be adapted in response to changes in a target's appearance that lead to drifts during tracking. An abrupt change detection triggers an update of tracker template using the bounding box produced by the detector, while in the case of a gradual change, the detector is used to update an evolving set of templates for robust matching. Experiments were performed using state-of-the-art Siamese-FC trackers and the YOLOv3 detector on a subset of videos from the OTB-100 dataset that mimic video surveillance scenarios. Results highlight the importance for reliable VOT of using accurate detectors. They also indicate that our adaptive Siamese trackers are robust to noisy object detections, and can significantly improve the performance of Siamese-FC tracking.