Jun Zhou

Yichao Zhang, Ningyuan Deng, Xinyuan Song et al.

After AlphaFold won the Nobel Prize, protein prediction with deep learning once again became a hot topic. We comprehensively explore advanced deep learning methods applied to protein structure prediction and design. It begins by examining recent innovations in prediction architectures, with detailed discussions on improvements such as diffusion based frameworks and novel pairwise attention modules. The text analyses key components including structure generation, evaluation metrics, multiple sequence alignment processing, and network architecture, thereby illustrating the current state of the art in computational protein modelling. Subsequent chapters focus on practical applications, presenting case studies that range from individual protein predictions to complex biomolecular interactions. Strategies for enhancing prediction accuracy and integrating deep learning techniques with experimental validation are thoroughly explored. The later sections review the industry landscape of protein design, highlighting the transformative role of artificial intelligence in biotechnology and discussing emerging market trends and future challenges. Supplementary appendices provide essential resources such as databases and open source tools, making this volume a valuable reference for researchers and students.

Jun Zhou, Dinghao Li, Nannan Li et al.

Recent advancements in multi-view 3D reconstruction and novel-view synthesis, particularly through Neural Radiance Fields (NeRF) and 3D Gaussian Splatting (3DGS), have greatly enhanced the fidelity and efficiency of 3D content creation. However, inpainting 3D scenes remains a challenging task due to the inherent irregularity of 3D structures and the critical need for maintaining multi-view consistency. In this work, we propose a novel 3D Gaussian inpainting framework that reconstructs complete 3D scenes by leveraging sparse inpainted views. Our framework incorporates an automatic Mask Refinement Process and region-wise Uncertainty-guided Optimization. Specifically, we refine the inpainting mask using a series of operations, including Gaussian scene filtering and back-projection, enabling more accurate localization of occluded regions and realistic boundary restoration. Furthermore, our Uncertainty-guided Fine-grained Optimization strategy, which estimates the importance of each region across multi-view images during training, alleviates multi-view inconsistencies and enhances the fidelity of fine details in the inpainted results. Comprehensive experiments conducted on diverse datasets demonstrate that our approach outperforms existing state-of-the-art methods in both visual quality and view consistency.

Wei Jin, Jun Zhou, Nannan Li et al.

In recent years, deep learning-based point cloud normal estimation has made great progress. However, existing methods mainly rely on the PCPNet dataset, leading to overfitting. In addition, the correlation between point clouds with different noise scales remains unexplored, resulting in poor performance in cross-domain scenarios. In this paper, we explore the consistency of intrinsic features learned from clean and noisy point clouds using an Asymmetric Siamese Network architecture. By applying reasonable constraints between features extracted from different branches, we enhance the quality of normal estimation. Moreover, we introduce a novel multi-view normal estimation dataset that includes a larger variety of shapes with different noise levels. Evaluation of existing methods on this new dataset reveals their inability to adapt to different types of shapes, indicating a degree of overfitting. Extensive experiments show that the proposed dataset poses significant challenges for point cloud normal estimation and that our feature constraint mechanism effectively improves upon existing methods and reduces overfitting in current architectures.

Jun Zhou, Wei Jin, Mingjie Wang et al.

With the burst development of neural networks in recent years, the task of normal estimation has once again become a concern. By introducing the neural networks to classic methods based on problem-specific knowledge, the adaptability of the normal estimation algorithm to noise and scale has been greatly improved. However, the compatibility between neural networks and the traditional methods has not been considered. Similar to the principle of Occam's razor, that is, the simpler is better. We observe that a more simplified process of surface fitting can significantly improve the accuracy of the normal estimation. In this paper, two simple-yet-effective strategies are proposed to address the compatibility between the neural networks and surface fitting process to improve normal estimation. Firstly, a dynamic top-k selection strategy is introduced to better focus on the most critical points of a given patch, and the points selected by our learning method tend to fit a surface by way of a simple tangent plane, which can dramatically improve the normal estimation results of patches with sharp corners or complex patterns. Then, we propose a point update strategy before local surface fitting, which smooths the sharp boundary of the patch to simplify the surface fitting process, significantly reducing the fitting distortion and improving the accuracy of the predicted point normal. The experiments analyze the effectiveness of our proposed strategies and demonstrate that our method achieves SOTA results with the advantage of higher estimation accuracy over most existed approaches.

Jun Zhou, Wei Jin, Mingjie Wang et al.

This paper presents an effective normal estimation method adopting multi-patch stitching for an unstructured point cloud. The majority of learning-based approaches encode a local patch around each point of a whole model and estimate the normals in a point-by-point manner. In contrast, we suggest a more efficient pipeline, in which we introduce a patch-level normal estimation architecture to process a series of overlapping patches. Additionally, a multi-normal selection method based on weights, dubbed as multi-patch stitching, integrates the normals from the overlapping patches. To reduce the adverse effects of sharp corners or noise in a patch, we introduce an adaptive local feature aggregation layer to focus on an anisotropic neighborhood. We then utilize a multi-branch planar experts module to break the mutual influence between underlying piecewise surfaces in a patch. At the stitching stage, we use the learned weights of multi-branch planar experts and distance weights between points to select the best normal from the overlapping parts. Furthermore, we put forward constructing a sparse matrix representation to reduce large-scale retrieval overheads for the loop iterations dramatically. Extensive experiments demonstrate that our method achieves SOTA results with the advantage of lower computational costs and higher robustness to noise over most of the existing approaches.

Mingjie Wang, Hao Cai, Jun Zhou et al.

Crowd counting is an important vision task, which faces challenges on continuous scale variation within a given scene and huge density shift both within and across images. These challenges are typically addressed using multi-column structures in existing methods. However, such an approach does not provide consistent improvement and transferability due to limited ability in capturing multi-scale features, sensitiveness to large density shift, and difficulty in training multi-branch models. To overcome these limitations, a Single-column Scale-invariant Network (ScSiNet) is presented in this paper, which extracts sophisticated scale-invariant features via the combination of interlayer multi-scale integration and a novel intralayer scale-invariant transformation (SiT). Furthermore, in order to enlarge the diversity of densities, a randomly integrated loss is presented for training our single-branch method. Extensive experiments on public datasets demonstrate that the proposed method consistently outperforms state-of-the-art approaches in counting accuracy and achieves remarkable transferability and scale-invariant property.

Jun Zhou, Hua Huang, Bin Liu et al.

In this paper, we propose a normal estimation method for unstructured 3D point clouds. In this method, a feature constraint mechanism called Local Plane Features Constraint (LPFC) is used and then a multi-scale selection strategy is introduced. The LPEC can be used in a single-scale point network architecture for a more stable normal estimation of the unstructured 3D point clouds. In particular, it can partly overcome the influence of noise on a large sampling scale compared to the other methods which only use regression loss for normal estimation. For more details, a subnetwork is built after point-wise features extracted layers of the network and it gives more constraints to each point of the local patch via a binary classifier in the end. Then we use multi-task optimization to train the normal estimation and local plane classification tasks simultaneously.Also, to integrate the advantages of multi-scale results, a scale selection strategy is adopted, which is a data-driven approach for selecting the optimal scale around each point and encourages subnetwork specialization. Specifically, we employed a subnetwork called Scale Estimation Network to extract scale weight information from multi-scale features. More analysis is given about the relations between noise levels, local boundary, and scales in the experiment. These relationships can be a better guide to choosing particular scales for a particular model. Besides, the experimental result shows that our network can distinguish the points on the fitting plane accurately and this can be used to guide the normal estimation and our multi-scale method can improve the results well. Compared to some state-of-the-art surface normal estimators, our method is robust to noise and can achieve competitive results.