Nicola Pezzotti

Segrey Kastryulin, Jamil Zakirov, Nicola Pezzotti et al.

Image quality assessment (IQA) algorithms aim to reproduce the human's perception of the image quality. The growing popularity of image enhancement, generation, and recovery models instigated the development of many methods to assess their performance. However, most IQA solutions are designed to predict image quality in the general domain, with the applicability to specific areas, such as medical imaging, remaining questionable. Moreover, the selection of these IQA metrics for a specific task typically involves intentionally induced distortions, such as manually added noise or artificial blurring; yet, the chosen metrics are then used to judge the output of real-life computer vision models. In this work, we aspire to fill these gaps by carrying out the most extensive IQA evaluation study for Magnetic Resonance Imaging (MRI) to date (14,700 subjective scores). We use outputs of neural network models trained to solve problems relevant to MRI, including image reconstruction in the scan acceleration, motion correction, and denoising. Our emphasis is on reflecting the radiologist's perception of the reconstructed images, gauging the most diagnostically influential criteria for the quality of MRI scans: signal-to-noise ratio, contrast-to-noise ratio, and the presence of artifacts. Seven trained radiologists assess these distorted images, with their verdicts then correlated with 35 different image quality metrics (full-reference, no-reference, and distribution-based metrics considered). The top performers -- DISTS, HaarPSI, VSI, and FID-VGG16 -- are found to be efficient across three proposed quality criteria, for all considered anatomies and the target tasks.

Chinmay Rao, Matthias van Osch, Nicola Pezzotti et al.

Since multiple MRI contrasts of the same anatomy contain redundant information, one contrast can guide the reconstruction of an undersampled subsequent contrast. To this end, several end-to-end learning-based guided reconstruction methods have been proposed. However, a key challenge is the requirement of large paired training datasets comprising raw data and aligned reference images. We propose a modular two-stage approach that does not require any k-space training data, relying solely on image-domain datasets, a large part of which can be unpaired. Additionally, our approach provides an explanatory framework for the multi-contrast problem based on the shared and non-shared generative factors underlying two given contrasts. A content/style model of two-contrast image data is learned from a largely unpaired image-domain dataset and is subsequently applied as a plug-and-play operator in iterative reconstruction. The disentanglement of content and style allows explicit representation of contrast-independent and contrast-specific factors. Consequently, incorporating prior information into the reconstruction reduces to a simple replacement of the aliased content of the reconstruction iterate with high-quality content derived from the reference scan. Combining this component with a data consistency step and introducing a general corrective process for the content yields an iterative scheme. We name this novel approach PnP-CoSMo. Various aspects like interpretability and convergence are explored via simulations. Furthermore, its practicality is demonstrated on the public NYU fastMRI DICOM dataset, showing improved generalizability compared to end-to-end methods, and on two in-house multi-coil raw datasets, offering up to 32.6\% more acceleration over learning-based non-guided reconstruction for a given SSIM.

Kirsten W. H. Maas, Danny Ruijters, Nicola Pezzotti et al.

Three-dimensional (3D) and dynamic 3D+time (4D) reconstruction of coronary arteries from X-ray coronary angiography (CA) has the potential to improve clinical procedures. However, there are multiple challenges to be addressed, most notably, blood-vessel structure sparsity, poor background and blood vessel distinction, sparse-views, and intra-scan motion. State-of-the-art reconstruction approaches rely on time-consuming manual or error-prone automatic segmentations, limiting clinical usability. Recently, approaches based on Neural Radiance Fields (NeRF) have shown promise for automatic reconstructions in the sparse-view setting. However, they suffer from long training times due to their dependence on MLP-based representations. We propose NerT-CA, a hybrid approach of Neural and Tensorial representations for accelerated 4D reconstructions with sparse-view CA. Building on top of the previous NeRF-based work, we model the CA scene as a decomposition of low-rank and sparse components, utilizing fast tensorial fields for low-rank static reconstruction and neural fields for dynamic sparse reconstruction. Our approach outperforms previous works in both training time and reconstruction accuracy, yielding reasonable reconstructions from as few as three angiogram views. We validate our approach quantitatively and qualitatively on representative 4D phantom datasets.

Nicola Pezzotti, Sahar Yousefi, Mohamed S. Elmahdy et al.

Adaptive intelligence aims at empowering machine learning techniques with the additional use of domain knowledge. In this work, we present the application of adaptive intelligence to accelerate MR acquisition. Starting from undersampled k-space data, an iterative learning-based reconstruction scheme inspired by compressed sensing theory is used to reconstruct the images. We adopt deep neural networks to refine and correct prior reconstruction assumptions given the training data. The network was trained and tested on a knee MRI dataset from the 2019 fastMRI challenge organized by Facebook AI Research and NYU Langone Health. All submissions to the challenge were initially ranked based on similarity with a known groundtruth, after which the top 4 submissions were evaluated radiologically. Our method was evaluated by the fastMRI organizers on an independent challenge dataset. It ranked #1, shared #1, and #3 on respectively the 8x accelerated multi-coil, the 4x multi-coil, and the 4x single-coil track. This demonstrates the superior performance and wide applicability of the method.

Shi Hu, Nicola Pezzotti, Max Welling

In healthcare applications, predictive uncertainty has been used to assess predictive accuracy. In this paper, we demonstrate that predictive uncertainty estimated by the current methods does not highly correlate with prediction error by decomposing the latter into random and systematic errors, and showing that the former is equivalent to the variance of the random error. In addition, we observe that current methods unnecessarily compromise performance by modifying the model and training loss to estimate the target and uncertainty jointly. We show that estimating them separately without modifications improves performance. Following this, we propose a novel method that estimates the target labels and magnitude of the prediction error in two steps. We demonstrate this method on a large-scale MRI reconstruction task, and achieve significantly better results than the state-of-the-art uncertainty estimation methods.