Xinyu Qin

Xinyu Qin, Anil K. Sood, Ruiheng Yu et al.

Clinical decision support AI systems (CDSASs) must adapt to evolving patient conditions in real-time while adhering to strict safety constraints. We present an online adaptive framework that integrates Treatment Effect (TE) estimation to quantify clinical benefits, a patient Digital Twin (DT) to simulate treatment trajectories, and Reinforcement Learning (RL) for sequential decision-making. The AI system is initially trained on historical medical records and operates in a continuous learning loop. To ensure safety, a rule-based module monitors vital signs and blocks contraindicated treatments. Cases with strong internal model disagreement are flagged for clinician review, simulated in our experiments via a pre-trained outcome model. We validate our framework using both a synthetic clinical simulator and a real-world ovarian cancer dataset from The Cancer Genome Atlas (TCGA). In both simulated and clinical settings, our method demonstrated superior effectiveness and stability in recommending treatments compared to standard computational baselines. Furthermore, the AI system maintains low latency and requires expert consultation for only a minority of cases in our experimental validation, demonstrating its potential as a safe, clinician-supervised tool for personalized medicine that continuously improves through practical use.

Xinyu Qin, Vicky Ye, Ruiheng Yu et al.

Delirium is common in hospitalized patients and is often missed in routine care. We present a user-centered interactive machine learning (UC-iML) framework for delirium detection support that combines physician-guided feature refinement with interpretable modeling. Using 3,862 labeled admissions from six Toronto hospitals in the General Medicine Inpatient Initiative (GEMINI), we integrate administrative variables, laboratory results, medications, and a radiology-derived text indicator. Physicians guide feature refinement and model evaluation, and Shapley Additive exPlanations (SHAP) are used to summarize feature attribution. We evaluate standard supervised classifiers with temporally separated holdout testing and a later-phase validation cohort. Compared with automated and baseline variants, the proposed framework shows better overall discrimination and stronger temporal robustness, while the explanations highlight clinically meaningful signals. These results support UC-iML as a practical human-in-the-loop framework for clinically relevant delirium modeling.

Bingsheng Peng, Shutao Zhang, Xi Zheng et al.

Accurate localized wireless channel modeling is a cornerstone of cellular network optimization, enabling reliable prediction of network performance during parameter tuning. Localized statistical channel modeling (LSCM) is the state-of-the-art channel modeling framework tailored for cellular network optimization. However, traditional LSCM methods, which infer the channel's Angular Power Spectrum (APS) from Reference Signal Received Power (RSRP) measurements, suffer from critical limitations: they are typically confined to single-cell, single-grid and single-carrier frequency analysis and fail to capture complex cross-domain interactions. To overcome these challenges, we propose RF-LSCM, a novel framework that models the channel APS by jointly representing large-scale signal attenuation and multipath components within a radiance field. RF-LSCM introduces a multi-domain LSCM formulation with a physics-informed frequency-dependent Attenuation Model (FDAM) to facilitate the cross frequency generalization as well as a point-cloud-aided environment enhanced method to enable multi-cell and multi-grid channel modeling. Furthermore, to address the computational inefficiency of typical neural radiance fields, RF-LSCM leverages a low-rank tensor representation, complemented by a novel Hierarchical Tensor Angular Modeling (HiTAM) algorithm. This efficient design significantly reduces GPU memory requirements and training time while preserving fine-grained accuracy. Extensive experiments on real-world multi-cell datasets demonstrate that RF-LSCM significantly outperforms state-of-the-art methods, achieving up to a 30% reduction in mean absolute error (MAE) for coverage prediction and a 22% MAE improvement by effectively fusing multi-frequency data.