Rishi Jain

Edwin H. Wintermute, Harmon Bhasin, Christina M. Agapakis et al.

As AI agents are incorporated into life science workflows, the capabilities that speed discovery might also enable misuse. We present BioSecBench-Refusal, a benchmark for risk identification and refusal behavior for biological research tasks. The benchmark pairs 61 Routine tasks, legitimate analyses adapted from the published literature, with 46 Red-Team tasks, fictional scenarios that resemble real research but conceal a biosecurity hazard. Across 16 model-harness configurations, refusal rates ranged from 7\% to 74\% on Routine tasks and 1\% to 62\% on Red-Team tasks, with many configurations refusing legitimate Routine work at comparable or higher rates than concealed hazards. Refusals were most often triggered by provider API filters applied prior to agentic reasoning. However, models given room to reason showed the potential to identify more real threats. We release BioSecBench-Refusal as a tool for model developers to calibrate capability and caution for agentic biotech R\&D.

Rishi Jain, Bohan Yu, Peter Wu et al.

Accurate modeling of the vocal tract is necessary to construct articulatory representations for interpretable speech processing and linguistics. However, vocal tract modeling is challenging because many internal articulators are occluded from external motion capture technologies. Real-time magnetic resonance imaging (RT-MRI) allows measuring precise movements of internal articulators during speech, but annotated datasets of MRI are limited in size due to time-consuming and computationally expensive labeling methods. We first present a deep labeling strategy for the RT-MRI video using a vision-only segmentation approach. We then introduce a multimodal algorithm using audio to improve segmentation of vocal articulators. Together, we set a new benchmark for vocal tract modeling in MRI video segmentation and use this to release labels for a 75-speaker RT-MRI dataset, increasing the amount of labeled public RT-MRI data of the vocal tract by over a factor of 9. The code and dataset labels can be found at \url{rishiraij.github.io/multimodal-mri-avatar/}.