Bei Liu

Han Wu, Wenjie Ruan, Jiangtao Wang et al.

The black-box nature of machine learning models hinders the deployment of some high-accuracy models in medical diagnosis. It is risky to put one's life in the hands of models that medical researchers do not fully understand. However, through model interpretation, black-box models can promptly reveal significant biomarkers that medical practitioners may have overlooked due to the surge of infected patients in the COVID-19 pandemic. This research leverages a database of 92 patients with confirmed SARS-CoV-2 laboratory tests between 18th Jan. 2020 and 5th Mar. 2020, in Zhuhai, China, to identify biomarkers indicative of severity prediction. Through the interpretation of four machine learning models, decision tree, random forests, gradient boosted trees, and neural networks using permutation feature importance, Partial Dependence Plot (PDP), Individual Conditional Expectation (ICE), Accumulated Local Effects (ALE), Local Interpretable Model-agnostic Explanations (LIME), and Shapley Additive Explanation (SHAP), we identify an increase in N-Terminal pro-Brain Natriuretic Peptide (NTproBNP), C-Reaction Protein (CRP), and lactic dehydrogenase (LDH), a decrease in lymphocyte (LYM) is associated with severe infection and an increased risk of death, which is consistent with recent medical research on COVID-19 and other research using dedicated models. We further validate our methods on a large open dataset with 5644 confirmed patients from the Hospital Israelita Albert Einstein, at São Paulo, Brazil from Kaggle, and unveil leukocytes, eosinophils, and platelets as three indicative biomarkers for COVID-19.

Zhicheng Huang, Zhaoyang Zeng, Bei Liu et al.

We propose Pixel-BERT to align image pixels with text by deep multi-modal transformers that jointly learn visual and language embedding in a unified end-to-end framework. We aim to build a more accurate and thorough connection between image pixels and language semantics directly from image and sentence pairs instead of using region-based image features as the most recent vision and language tasks. Our Pixel-BERT which aligns semantic connection in pixel and text level solves the limitation of task-specific visual representation for vision and language tasks. It also relieves the cost of bounding box annotations and overcomes the unbalance between semantic labels in visual task and language semantic. To provide a better representation for down-stream tasks, we pre-train a universal end-to-end model with image and sentence pairs from Visual Genome dataset and MS-COCO dataset. We propose to use a random pixel sampling mechanism to enhance the robustness of visual representation and to apply the Masked Language Model and Image-Text Matching as pre-training tasks. Extensive experiments on downstream tasks with our pre-trained model show that our approach makes the most state-of-the-arts in downstream tasks, including Visual Question Answering (VQA), image-text retrieval, Natural Language for Visual Reasoning for Real (NLVR). Particularly, we boost the performance of a single model in VQA task by 2.17 points compared with SOTA under fair comparison.